Results 101 to 110 of about 23,505 (207)

Multicenter Assessment of Combined Brain and Cervical Spinal cord 3T MP2RAGE T1 Measurements for Reliable Tissue Microstructure Quantification

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
Reliability of simultaneous brain and spinal cord magnetization‐prepared two rapid acquisition gradient echoes (MP2RAGE) T1 measurements was evaluated in a multicentre context. Mean intra‐site/inter‐site/between‐participant coefficients of variation (COV) were 0.4/0.9/2.3% for the brain ROIs and 2.0/2.4/1.7% for the cSC, confirming the potential of T1 ...
Malo Gaubert, Benoit Combès, Henitsoa Rasoanandrianina, Jean‐Christophe Ferré, Alice Dufey, Raphaël Chouteau, Bertrand Audoin, Jean Pelletier, Sarah Demortière, Anne Kerbrat, Elise Bannier, Virginie Callot   +11 more
wiley   +1 more source

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +1 more source

Study and analysis of the correlation between lumbar spondylolisthesis and Modic changes

Frontiers in Surgery
BackgroundThis study aimed to explore the risk factors of Modic changes in lumbar spondylolisthesis.MethodsThe distribution of Modic changes in different types of lumbar spondylolisthesis, degree of spondylolisthesis, and degree of intervertebral disc ...
Guang-qing Li, Xiao Kang, Wei Li, Shi-shen Pei   +3 more
doaj   +1 more source

Prevalence of Chronic Pain and Associated Factors Among Nursing Students in Heilongjiang Province, China: A Cross‐Sectional Study

Nursing Open, Volume 13, Issue 8, August 2026.
ABSTRACT Aim This study explored the prevalence and potential factors influencing chronic pain and provided increased theoretical and practical support for future studies on nursing students from a novel perspective. Design This study applied a cross‐sectional study design.
Siqi Liu, Yujin Xie, Zhengxi Chen, Xiwei Chen, Lei Cao, Yue Qin, Mei Yin, Yang Fu, Lei Shi   +8 more
wiley   +1 more source

Finite element model reveals the involvement of cartilage endplate in quasi-static biomechanics of intervertebral disc degeneration

Heliyon
Background and objective: The intrinsic link between the compositional and structural attributes and the biomechanical functionality is evident in intervertebral discs.
Yujun Zhang, Yanli Pan, Xinning Mao, Du He, Liangping Zhang, Wei Cheng, Chengyue Zhu, Hang Zhu, Wei Zhang, HongTing Jin, Hao Pan, Dong Wang   +11 more
doaj   +1 more source

Directional X‐Ray Scattering and Microtomography for Laboratory‐Based Imaging of Fibrous Materials and Biological Tissues

Small Science, Volume 6, Issue 8, August 2026.
A compact laboratory X‐ray system enables directional dark‐field imaging and tomography with sensitivity to scattering along two orthogonal directions. The approach provides volumetric mapping of sub‐resolution microstructure in engineering and biological samples, which reveals structural heterogeneity, fiber organization, and anisotropic scattering ...
Carlos Navarrete‐León, Álvaro José González‐Grajales, Harry Allan, Adam Doherty, Alissa Parmenter, Rocco D’Antuono, David Bate, Alberto Astolfo, Silvia Cipiccia, Charlotte K. Hagen, Alessandro Olivo, Marco Endrizzi   +11 more
wiley   +1 more source

Intervertebral Disc Degeneration [PDF]

The American Journal of Pathology, 2004
François Rannou, Tzong-Shyuan Lee, Rui-Hai Zhou, Jennie Chin, Jeffrey C. Lotz, Marie-Anne Mayoux-Benhamou, Jacques Patrick Barbet, Alain Chevrot, John Y.-J. Shyy   +8 more
openaire   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, Volume 249, Issue 2, Page 435-444, August 2026.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source