Cell Proliferation, EarlyView.Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu +4 more
wiley +1 more source
Intervertebral Disc Degeneration
, 2017 The human spine consists of 23 intervertebral discs adjoining the vertebral bodies. These discs provide mechanical support and spinal motion and function to distribute loads from daily activities. Tissues of intervertebral discs share similarities to those of diarthrodial joints, such as a thin layer of cartilage that lines the interface between the ...
Akansha M. Shah +3 more
openaire +5 more sources
Finite Element Analysis of Stress Distribution and Range of Motion in Discogenic Back Pain [PDF]
NeurospineObjective Precise knowledge regarding the mechanical stress applied to the intervertebral disc following each individual spine motion enables physicians and patients to understand how people with discogenic back pain should be guided in their exercises ...
Pyung-Goo Cho +3 more
doaj +1 more source
An investigation into the effectiveness of collagenase for the percutaneous discolysis of thoracolumbar intervertebral discs in the dog : a thesis presented in partial fulfilment of the requirements for the degree of Master of Veterinary Science at Massey University [PDF]
, 1993 This investigation compared the effectiveness of chemonucleolysis with 500 units of collagenase, to lateral fenestration of the thoracolumbar intervertebral discs of the non-chondrodystrophoid dog.
Bray, Jonathan Peter
core
Cell Proliferation, EarlyView.Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang +14 more
wiley +1 more source
Cellular and molecular mechanisms of diabetes-mediated disc degeneration
Frontiers in EndocrinologyThe aging population and lifestyle changes are contributing to a yearly increase in the incidence of spinal degenerative diseases, which significantly lead to chronic pain, neurological dysfunction, and diminished quality of life, with intervertebral ...
Hui Wang +17 more
doaj +1 more source
Biomechanical Tolerance of Whole Lumbar Spines in Straightened Posture Subjected to Axial Acceleration [PDF]
, 2017 Quantification of biomechanical tolerance is necessary for injury prediction and protection of vehicular occupants. This study experimentally quantified lumbar spine axial tolerance during accelerative environments simulating a variety of military and ...
Baisden, Jamie L. +9 more
core +2 more sources
Cone beam computed tomographic myelography in horses with cervical vertebral compressive myelopathy
Equine Veterinary Journal, EarlyView.Abstract Background While computed tomographic (CT) myelography is increasingly available and has been evaluated in alive horses, objective criteria for diagnosing cervical vertebral compressive myelopathy (CVCM) are lacking. Objectives To establish morphometric dimensions of the cervical vertebral canal and spinal cords from horses with CVCM and ...
Sonia González‐Medina +4 more
wiley +1 more source
The Relationship between HELQ Expression and Intervertebral Disc Degeneration
Global Spine Journal, 2016 Introduction Degeneration of the intervertebral disc, mainly of nucleus pulposus, is strongly implicated as a cause of low back pain. However, the mechanism of disc degeneration is not clear.
Shanhu Huang +3 more
doaj +1 more source
Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study. [PDF]
, 2016 PublishedJournal ArticleThe final publication is available at Springer via http://dx.doi.org/10.1007/s00330-014-3382-8OBJECTIVES: Although magnetic resonance is widely spread to assess qualitatively disc morphology, a simple method to determine reliably ...
Bonneau, D +7 more
core +1 more source