Results 91 to 100 of about 23,505 (207)
JOR SPINE, Volume 9, Issue 3, September 2026.We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang +8 more
wiley +1 more source
JOR SPINE, Volume 9, Issue 3, September 2026.ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche +9 more
wiley +1 more source
JOR SPINE, Volume 9, Issue 3, September 2026.The inferior facet of the L2 vertebra and the superior facet of the L3 vertebra were harvested from ovine lumbar spines. The spatial biomechanical properties of the facet cartilage surfaces were determined by indentation mapping. Cartilage structure was spatially analyzed on a macroscopic and microscopic level.
Luisa de Roy +6 more
wiley +1 more source
Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration
JOR SPINE, Volume 9, Issue 3, September 2026.ABSTRACT Background The intervertebral disc serves a critical role in spine function, but with aging and degeneration the disc undergoes changes that alter disc mechanics, and degeneration is often implicated in low back pain. The objective of this study was to quantify and evaluate the impact of aging and degeneration on in vivo lumbar disc mechanics ...
Harrah R. Newman +3 more
wiley +1 more source
Frontiers in Bioengineering and BiotechnologyDegeneration of intervertebral discs and facet joints are common conditions that are thought to be interrelated. This study aimed to investigate the morphological interplay between disc and facet degeneration, as well as relationships between adjacent ...
Hendrik Schmidt +4 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT The paraspinal hook‐needle intervention is a minimally invasive needle‐based procedure performed under local anesthesia using a specialized hook‐shaped needle at clinically selected lumbar segments. We report the case of a 70‐year‐old woman who presented with intermittent low back pain for more than 10 years, recently aggravated and ...
Mengying Xiao +4 more
wiley +1 more source
Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley +1 more source
Intervertebral disc degeneration, inflammation, and bioactive lipids
Recent Trends in PharmacologyIntervertebral disc degeneration, inflammation, and bioactive lipidsIntervertebral disc degenerationIntervertebral disc (IVD) degeneration is a common condition that is associated with significant morbidity.
Undurti Das, Ahmet Hacımüftüoğlu
doaj +1 more source
Regenerative strategies for intervertebral disc degeneration
Journal of Orthopaedic TranslationLow back pain (LBP) is a global health problem, primarily caused by intervertebral disc (IVD) degeneration. Current treatments focus on symptom relief without addressing the underlying degenerative mechanisms. Regenerative strategies have emerged as promising therapies through the use of functional biomaterials and stem cells capable of modulating key ...
Raed H. Ogaili +4 more
openaire +4 more sources