Results 91 to 100 of about 23,413 (232)

Degenerative relationships in lumbar intervertebral discs and facet joints: an MRI-based comparative study of asymptomatic individuals and patients with chronic and intermittent low back pain

Frontiers in Bioengineering and Biotechnology
Degeneration of intervertebral discs and facet joints are common conditions that are thought to be interrelated. This study aimed to investigate the morphological interplay between disc and facet degeneration, as well as relationships between adjacent ...
Hendrik Schmidt, Sandra Reitmaier, Daishui Yang, Georg Duda, Matthias Pumberger   +4 more
doaj   +1 more source

Zhiqiao Gancao decoction regulated JAK2/STAT3/ macrophage M1 polarization to ameliorate intervertebral disc degeneration

Heliyon
Background: Zhiqiao Gancao decoction (ZQGCD) was created by Professor Gong Zhengfeng, a renowned Chinese medicine expert. Clinical studies have shown its efficacy in alleviating pain and enhancing lumbar function in intervertebral disc degeneration (IDD)
Zeling Huang, Xiaofeng Shen, Hua Chen, Zaishi Zhu, Binjie Lu, Long Zhang, Yujiang Liu, Yuwei Li, Bo Xu   +8 more
doaj   +1 more source

A Novel Decomposition‐Based Growth Model for Simulating Stress‐Modulated Spinal Growth

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 6, June 2026.
This study introduces the first decomposition‐based finite‐strain growth model for a simplified Functional Spinal Unit, where growth occurs simultaneously with mechanical loading. The approach eliminates the major physical inconsistency of sequential methods—growth in an artificial stress‐free configuration—while preventing mesh distortion and ...
Serhat Onur Çakmak, Ercan Gürses
wiley   +1 more source

What Is Your Diagnosis? Leukocytosis With Abnormal WDF and WNR Scattergrams From the Sysmex XN‐1000V in a Dog

Veterinary Clinical Pathology, EarlyView.
Javier Martínez‐Caro, Marta Lemos, Josep Pastor   +2 more
wiley   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Regenerative strategies for intervertebral disc degeneration

Journal of Orthopaedic Translation
Low back pain (LBP) is a global health problem, primarily caused by intervertebral disc (IVD) degeneration. Current treatments focus on symptom relief without addressing the underlying degenerative mechanisms. Regenerative strategies have emerged as promising therapies through the use of functional biomaterials and stem cells capable of modulating key ...
Raed H. Ogaili, Ahmed Alassal, Nurul Fariha Za'aba, Izzat Zulkiflee, Isma Liza Mohd Isa   +4 more
openaire   +4 more sources

Viscoelastic and Morphologic Changes in the Lumbar Intervertebral Discs of the 5xFAD Mouse Model of Alzheimer's Disease

JOR SPINE, Volume 9, Issue 2, June 2026.
The intervertebral discs (IVDs) from mice with amyloid pathologies are larger, flatter, and exhibit increased energy absorption, making these IVDs more susceptible to damage. This heightened vulnerability may predispose elderly individuals with AD to disc injuries, accelerating IVD degeneration and spinal pain. ABSTRACT Background Chronic low back pain,
C. E. Gonzalez, C. A. Schurman, K. A. Wilson, B. Schilling, L. M. Ellerby, S. Y. Tang   +5 more
wiley   +1 more source

A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology

JOR SPINE, Volume 9, Issue 2, June 2026.
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou, Zerihun G. Workineh, Maria Segarra‐Queralt, Francis Kiptengwer Chemorion, Paola Bermudez‐Lekerika, Exarchos Kanelis, Katherine B. Crump, Benjamin Gantenbein, Leonidas G. Alexopoulos, Christine L. Le Maitre, Janet Piñero, Jérôme Noailly   +11 more
wiley   +1 more source

Patients With Chronic Low Back Pain Without Advanced Disk Degeneration Exhibit Gut Microbiome Dysbiosis: Evidence From an Age‐, Sex‐, and BMI‐Matched Pilot Study

JOR SPINE, Volume 9, Issue 2, June 2026.
Chronic low back pain in patients without advanced disc degeneration is associated with gut microbiome dysbiosis, marked by reduced microbial diversity and altered bacterial composition. These findings support a gut–disk axis in which impaired gut barrier integrity and systemic inflammation may contribute to disc inflammation, nociceptive fiber ...
Stone Sima, Thomas Jeffries, Alisha Sial, Suhani Sharma, Neha Chopra, Fan Zhang, Georgina Hold, Wentian Li, Ji Tu, Victor Chen, Ashish Diwan   +10 more
wiley   +1 more source

Study and analysis of the correlation between lumbar spondylolisthesis and Modic changes

Frontiers in Surgery
BackgroundThis study aimed to explore the risk factors of Modic changes in lumbar spondylolisthesis.MethodsThe distribution of Modic changes in different types of lumbar spondylolisthesis, degree of spondylolisthesis, and degree of intervertebral disc ...
Guang-qing Li, Xiao Kang, Wei Li, Shi-shen Pei   +3 more
doaj   +1 more source