Results 61 to 70 of about 23,505 (207)

Cellular and molecular mechanisms of diabetes-mediated disc degeneration

Frontiers in Endocrinology
The aging population and lifestyle changes are contributing to a yearly increase in the incidence of spinal degenerative diseases, which significantly lead to chronic pain, neurological dysfunction, and diminished quality of life, with intervertebral ...
Hui Wang, Hui Wang, Moran Suo, Moran Suo, Kaizhong Wang, Kaizhong Wang, Shuang Chen, Shuang Chen, Xiangyan Liu, Xiangyan Liu, Qiwen Wang, Qiwen Wang, Zhenbo Wang, Zhenbo Wang, Xin Chen, Xin Chen, Zhonghai Li, Zhonghai Li   +17 more
doaj   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

The Relationship between HELQ Expression and Intervertebral Disc Degeneration

Global Spine Journal, 2016
Introduction Degeneration of the intervertebral disc, mainly of nucleus pulposus, is strongly implicated as a cause of low back pain. However, the mechanism of disc degeneration is not clear.
Shanhu Huang, Yu Zhang, Zhili Liu, Jiaming Liu   +3 more
doaj   +1 more source

Clinical practices in the management of cervical Hansen type I intervertebral disc herniation among veterinary neurologists in North America and Europe

Journal of Small Animal Practice, EarlyView.
Objectives To describe current clinical practices in the management of cervical Hansen type I intervertebral disc herniation among American College of Veterinary Internal Medicine/European College of Veterinary Neurology neurologists. Materials and Methods An anonymous web‐based survey was distributed via professional listservs between October and ...
A. Mondino, M. Riobó, N. J. Olby, S. Moore, P. J. Early   +4 more
wiley   +1 more source

Mn-MIL-100@AKG alleviates intervertebral disc degeneration by regulating mitophagy

Materials Today Bio
Currently, the therapy of intervertebral disc degeneration (IDD) mostly focuses on basic molecular causes. Research on the alterations of metabolites in the intervertebral disc prior to and following intervertebral disc degeneration (IDD) remains ...
Xianglong Chen, Haiyang Gao, Anran Zhang, Pengzhi Shi, Yuhang Chen, Zhangrong Cheng, Wang Wu, Wenbo Wu, Yukun Zhang   +8 more
doaj   +1 more source

The relation between sagittal morphology of the lumbosacral spine and the degree of lumbar intervertebral disc degeneration

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: We investigated the relationship between the lumbosacral morphology and degree of intervertebral disc degeneration in a large sample of young patients. In addition, the relation between various morphological parameters (sacral table angle and
Tarkan Ergun, Hatice Lakadamyali, Mehmet Sukru Sahin   +2 more
doaj   +1 more source

Factors and Experiences Associated With Unscheduled Hospital Readmission After Lateral Lumbar Interbody Fusion: A Case–Controlled Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1389-1396, May 2025.
The research utilized a case–control approach to contrast patients experiencing unscheduled readmissions with those undergoing planned readmissions due to staged surgery. Findings indicated a 3.88% rate of unscheduled readmissions, mainly linked to adjacent segment disease, with 3.35% necessitating reoperation.
Wangmi Liu, Feng Zhang, Yiqing Tao, Hao Li, Qixin Chen, Fangcai Li   +5 more
wiley   +1 more source

Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles

Journal of Orthopaedic Translation
Intervertebral disc degeneration is the leading cause of low back pain, imposing significant burdens on patients, societies, and economies. Advancements in regenerative medicine have spotlighted extracellular vesicles as promising nanoparticles for ...
Shanfeng Chen, Yiming Dou, Yiming Zhang, Xun Sun, Xinyu Liu, Qiang Yang   +5 more
doaj   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

Postoperative Curvature Loss in Three‐Level Anterior Cervical Discectomy and Fusion With Zero‐Profile Device

Orthopaedic Surgery, EarlyView.
This study focused on postoperative curvature loss (PCL) for three‐level anterior cervical discectomy and fusion (ACDF) with Zero‐Profile device. Lower preoperative curvature and preoperative T1 slope were predictive factors of PCL. Postoperative change of TPE distance and T1 slope were risk factors. PCL may impair patients' quality of life.
Zhihao Liu, Xiaqing Sheng, Chengyi Huang, Tingkui Wu, Kangkang Huang, Beiyu Wang, Chen Ding, Ying Hong, Yang Meng, Hao Liu   +9 more
wiley   +1 more source