Results 61 to 70 of about 23,413 (232)
Finite Element Analysis of Stress Distribution and Range of Motion in Discogenic Back Pain [PDF]
NeurospineObjective Precise knowledge regarding the mechanical stress applied to the intervertebral disc following each individual spine motion enables physicians and patients to understand how people with discogenic back pain should be guided in their exercises ...
Pyung-Goo Cho +3 more
doaj +1 more source
Cell Proliferation, EarlyView.Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang +14 more
wiley +1 more source
The FEBS Journal, EarlyView.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source
The Relationship between HELQ Expression and Intervertebral Disc Degeneration
Global Spine Journal, 2016 Introduction Degeneration of the intervertebral disc, mainly of nucleus pulposus, is strongly implicated as a cause of low back pain. However, the mechanism of disc degeneration is not clear.
Shanhu Huang +3 more
doaj +1 more source
Journal of Anatomy, EarlyView.This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne +7 more
wiley +1 more source
Acta Orthopaedica et Traumatologica Turcica, 2020 Objectives: We investigated the relationship between the lumbosacral morphology and degree of intervertebral disc degeneration in a large sample of young patients. In addition, the relation between various morphological parameters (sacral table angle and
Tarkan Ergun +2 more
doaj +1 more source
Orthopaedic Surgery, Volume 17, Issue 5, Page 1389-1396, May 2025.The research utilized a case–control approach to contrast patients experiencing unscheduled readmissions with those undergoing planned readmissions due to staged surgery. Findings indicated a 3.88% rate of unscheduled readmissions, mainly linked to adjacent segment disease, with 3.35% necessitating reoperation.
Wangmi Liu +5 more
wiley +1 more source
Mn-MIL-100@AKG alleviates intervertebral disc degeneration by regulating mitophagy
Materials Today BioCurrently, the therapy of intervertebral disc degeneration (IDD) mostly focuses on basic molecular causes. Research on the alterations of metabolites in the intervertebral disc prior to and following intervertebral disc degeneration (IDD) remains ...
Xianglong Chen +8 more
doaj +1 more source
Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu +9 more
wiley +1 more source
Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles
Journal of Orthopaedic TranslationIntervertebral disc degeneration is the leading cause of low back pain, imposing significant burdens on patients, societies, and economies. Advancements in regenerative medicine have spotlighted extracellular vesicles as promising nanoparticles for ...
Shanfeng Chen +5 more
doaj +1 more source