Results 61 to 70 of about 39,314 (264)

Research progress on macrophage polarization during the degeneration process of lumbar intervertebral discs [PDF]

Jichu yixue yu linchuang
During pathological progression of lumbar intervertebral disc degeneration (LIDD), macrophage polarization functions as a critical regulatory mechanism through the dynamic transition between M1 and M2 phenotypes.
CHEN Wang, LI Xugui, LI Ying
doaj   +1 more source

Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients. [PDF]

, 2020
OBJECTIVE: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration.
Anderson, D Greg, Antonacci, Christopher L, Kepler, Chris K, Koerner, John D, Markova, Dessislava Z, Mendelis, Joseph, Schroeder, Greg D, Vaccaro, Alexander R   +7 more
core   +1 more source

Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation [PDF]

, 2017
Background: Ascending/descending myelomalacia (ADMM) is a severe complication of thoracolumbar intervertebral disk herniation (TL-IVDH) in dogs. Hypothesis/Objectives: To investigate the prevalence and risk factors for ADMM in nonambulatory dogs with ...
Aikawa, Amsellem, Bergknut, Bezuidenhout, Boekhoff, Ferreira, Fingeroth, Griffiths, Henke, Henke, Ito, Jeffery, Jeffery, Kato, Kranenburg, Lahunta, Laitinen, Levine, Lu, Marquis, Mayer, Muguet-Chanoit, Okada, Okada, Olby, Olby, Pais, Penning, Platt, Priester, Sato, Scott, Shinzato, Smolders, Zachary   +34 more
core   +1 more source

Genetic factors in intervertebral disc degeneration

Genes & Diseases, 2016
Low back pain (LBP) is a major cause of disability and imposes huge economic burdens on human society worldwide. Among many factors responsible for LBP, intervertebral disc degeneration (IDD) is the most common disorder and is a target for intervention. The etiology of IDD is complex and its mechanism is still not completely understood.
Feng, Yi, Egan, Brian, Wang, Jinxi
openaire   +2 more sources

The role of ferroptosis in intervertebral disc degeneration

Frontiers in Cell and Developmental Biology, 2023
Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of the most widespread health issues worldwide, intervertebral disc degeneration (IVDD) is recognized as a key contributor to back and neck discomfort.
Chunyang Fan, Genglei Chu, Zilin Yu, Zhongwei Ji, Zhongwei Ji, Fanchen Kong, Lingye Yao, Jiale Wang, Dechun Geng, Xiexing Wu, Haiqing Mao   +10 more
openaire   +3 more sources

Factors Affecting Outcomes in Anterior Cervical Spine Surgery

The Laryngoscope, EarlyView.
This retrospective cohort study examined perioperative complications after anterior cervical spine surgery (ACSS) in 3401 patients treated at a tertiary academic institution. Otolaryngologist co‐surgeons in revision and upper cervical spine (C1‐4) cases, and high‐volume spine surgeons (≥ 15 annual cases) were associated with lower complication rates ...
Nana‐Hawwa Abdul‐Rahman, Hansen Deng, Jonathan Goulazian, Cynthia McMahan, Peter C. Gerszten, Carl H. Snyderman   +5 more
wiley   +1 more source

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +1 more source

Cell therapy for the degenerating intervertebral disc [PDF]

Translational Research, 2017
Spinal conditions related to intervertebral disc (IVD) degeneration cost billions of dollars in the US annually. Despite the prevalence and soaring cost, there is no specific treatment that restores the physiological function of the diseased IVD. Thus, it is vital to develop new treatment strategies to repair the degenerating IVD.
Wei Tong, Zhouyu Lu, Ling Qin, Robert L. Mauck, Harvey E. Smith, Lachlan J. Smith, Neil R. Malhotra, Martin F. Heyworth, Franklin Caldera, Motomi Enomoto-Iwamoto, Yejia Zhang   +10 more
openaire   +2 more sources

Social Determinants of Spinal Pathology in Adolescents From Urban Centers in the Post‐Medieval Netherlands (1650–1850 CE)

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT The study of trauma in individuals undergoing growth and development remains an understudied area of research but can provide unique insights into the lived experiences and social identities of young people in the past. This study examines vertebral compression fractures and Schmorl's nodes in children and adolescents (1–20 years at death ...
Meghan D. Langlois, Rachel Schats, Sarah Burrow, Megan B. Brickley   +3 more
wiley   +1 more source

The causality between smoking and intervertebral disc degeneration mediated by IL-1β secreted by macrophage: A Mendelian randomization study

Heliyon
There is still a lack of high-level evidence regarding the causal relationship between smoking and intervertebral disc degenerative diseases. This study utilized data from genome wide analysis studies and conducted two-sample Mendelian randomization ...
Zhaopu Han, Yicheng Chen, Xiaojian Ye
doaj   +1 more source