Results 51 to 60 of about 39,314 (264)

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Machine learning and single-cell analysis identify the mitophagy-associated gene TOMM22 as a potential diagnostic biomarker for intervertebral disc degeneration

Heliyon
Background: Mitophagy selectively eliminates potentially cytotoxic and damaged mitochondria and effectively prevents excessive cytotoxicity from damaged mitochondria, thereby attenuating inflammatory and oxidative responses.
Yinghao Wu, Shengting Wu, Zhiheng Chen, Erzhu Yang, Haiyue Yu, Guowang Zhang, XiaoFeng Lian, JianGuang Xu   +7 more
doaj   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Investigation of the Role of Osteoporotic Vertebra Degeneration on the Stability of the Lumbar Spine: In Silico Modelling under Compressive Loading

Bioengineering
An evaluation of the impact of osteoporosis on loss of spinal stability, with or without intervertebral disc degeneration, using computational analysis is presented.
Olga Chabarova, Jelena Selivonec, Alicia Menendez Hurtado   +2 more
doaj   +1 more source

Protective Effect of Polygonatum sibiricum Polysaccharides on Apoptosis, Inflammation, and Oxidative Stress in Nucleus Pulposus Cells of Rats with the Degeneration of the Intervertebral Disc

International Journal of Polymer Science, 2019
Objective. Polygonatum sibiricum polysaccharide (PSP) has antioxidant activity, immune enhancement, and other biological properties. However, the effect of PSP on intervertebral disc degeneration has not been reported.
Zhaohui Zhai, Zhaoxin Li, Zhonglei Ji, Xiaosheng Lu   +3 more
doaj   +1 more source

Comparison of medical and surgical treatment for acute cervical compressive hydrated nucleus pulposus extrusion in dogs [PDF]

, 2017
Although successful outcomes have been reported after medical and surgical treatment for dogs with cervical hydrated nucleus pulposus extrusion (HNPE), it is unknown which treatment option is preferred.
Beltran, Cardy, Crawford, da Costa, De Decker, De Decker, De Risio, De Risio, Dolera, Falzone, Fardon, Fenn, Hamilton, Hillman, Jeffery, Kamishina, Konar, Lowrie, Manunta, Olby, Royaux, Sharp, Smolders, Yousefifard   +23 more
core   +2 more sources

Cervical intervertebral disc degeneration and dizziness

World Journal of Clinical Cases, 2021
Clinical studies have found that patients withcervical degenerative disease are usually accompanied by dizziness. Anterior cervical surgery can eliminate not only chronic neck pain, cervical radiculopathy or myelopathy, but also dizziness. Immunohistochemical studies show that a large number of mechanoreceptors, especially Ruffini corpuscles, are ...
Liu, Tang-Hua, Liu, Yan-Qing, Peng, Bao-Gan   +2 more
openaire   +2 more sources

The Impact of Aging on the Anatomical Course of the Azygos Vein: A Retrospective, Computed Tomography Study

Clinical Anatomy, EarlyView.
ABSTRACT The azygos vein (AV) is typically described as ascending vertically to the right of the vertebral column before arching anteriorly to drain into the superior vena cava. However, a small number of studies suggest that it is found leftward in older adults.
Lauren R. Hector, Hania Paverd, Arthikkaa Thavakumar, Cecilia Brassett, Timothy J. Sadler   +4 more
wiley   +1 more source

Expression and Localization of aquaporin‐1 in Temporomandibular Joint Disc with Internal Derangement [PDF]

, 2012
Background: Internal derangement is the most frequent arthropathy affecting the temporomandibular joint, where its commonest form is anterior disc displacement with or without reduction.
Almeida, Luis Eduardo, Caltabiano, Rosario, Carnazza, Maria Luisa, Galanti, Concetta, Leonardi, Rosalia, Loreto, Carla, Musumeci, Giuseppe, Pannone, Giuseppe   +7 more
core   +2 more sources

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source