Results 51 to 60 of about 23,413 (232)

Molecular Mechanisms of Intervertebral Disc Degeneration

Spine Surgery and Related Research, 2019
Intervertebral disc degeneration is a well-known cause of disability, the result of which includes neck and back pain with associated mobility limitations. The purpose of this article is to provide an overview of the known molecular mechanisms through which intervertebral disc degeneration occurs as a result of complex interactions of exogenous and ...
Rider, Sean M., Mizuno, Shuichi, Kang, James D.   +2 more
openaire   +4 more sources

Next‐Generation Paleopathology: Using Commercial AI in Bioarchaeological Diagnosis

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Artificial intelligence encompasses computational systems capable of performing cognitive functions such as learning, reasoning, and problem‐solving. Within this domain, generative AI and large language models such as ChatGPT, Gemini, and Copilot have shown significant potential in clinical diagnostics.
Jessica Mongillo, Giulia Vescovo, Giulia Manzo, Nicoletta Zedda, Barbara Bramanti   +4 more
wiley   +1 more source

TWEAK and TSLP in disc degeneration and spontaneous hernia resorption

JOR Spine, 2020
Spontaneous degeneration of an intervertebral disc is caused by inflammation that accompanies exposure of the avascular nucleus pulposus to circulation, triggering an autoimmune inflammatory reaction.
Tetsuro Ohba, Hirotaka Haro
doaj   +1 more source

Musculoskeletal Outcomes of Glucagon‐Like Peptide‐1 Receptor Agonists Versus Other Antiobesity Agents in Nondiabetic Adults

Obesity, EarlyView.
ABSTRACT Objective This study aimed to evaluate the association of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) with risks of osteoporosis, major osteoporotic fractures, and degenerative musculoskeletal disorders in nondiabetic adults with obesity compared with other obesity medications.
Jie‐Syuan Wu, Lee‐Yuan Lin, Jia‐Wei Sun, Wei‐Ting Yu, Fara Silvia Yuliani, Shyh‐Hsiang Lin   +5 more
wiley   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats

Brazilian Journal of Medical and Biological Research, 2013
Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies.
A.C. Issy, V. Castania, M. Castania, C.E.G. Salmon, M.H. Nogueira-Barbosa, E. Del Bel, H.L.A. Defino   +6 more
doaj   +3 more sources

Intervertebral Disc Degeneration

, 2017
The human spine consists of 23 intervertebral discs adjoining the vertebral bodies. These discs provide mechanical support and spinal motion and function to distribute loads from daily activities. Tissues of intervertebral discs share similarities to those of diarthrodial joints, such as a thin layer of cartilage that lines the interface between the ...
Akansha M. Shah, Sarah Yoon Ji Kwon, Wilson C. W. Chan, Danny Chan   +3 more
openaire   +5 more sources

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

Arthritis Research & Therapy, 2023
Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs).
Kun Wang, Dengbo Yao, Yuxi Li, Ming Li, Weike Zeng, Zhuangyao Liao, Engming Chen, Shixin Lu, Kaihui Su, Zhen Che, Yuwei Liang, Peng Wang, Lin Huang   +12 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cellular and molecular mechanisms of diabetes-mediated disc degeneration

Frontiers in Endocrinology
The aging population and lifestyle changes are contributing to a yearly increase in the incidence of spinal degenerative diseases, which significantly lead to chronic pain, neurological dysfunction, and diminished quality of life, with intervertebral ...
Hui Wang, Hui Wang, Moran Suo, Moran Suo, Kaizhong Wang, Kaizhong Wang, Shuang Chen, Shuang Chen, Xiangyan Liu, Xiangyan Liu, Qiwen Wang, Qiwen Wang, Zhenbo Wang, Zhenbo Wang, Xin Chen, Xin Chen, Zhonghai Li, Zhonghai Li   +17 more
doaj   +1 more source