Results 121 to 130 of about 23,413 (232)

Circadian regulation in intervertebral disc degeneration: mechanisms and clinical implications. [PDF]

Front Mol Biosci
Zhao J, Wang S.
europepmc   +1 more source

Effects of Physical Exercise on Pain in Patients With Lumbar Disc Herniation: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials

Musculoskeletal Care, Volume 24, Issue 2, June 2026.
ABSTRACT Objective The aim of this study was to analyse the effects of physical exercise on pain in patients with lumbar disc herniation, regardless of whether they had undergone surgery. Methods A meta‐analysis was conducted according to the PRISMA guidelines.
Diego Gama Linhares, Bruno Gama Linhares, Lilliany de Souza Cordeiro, Claudio Joaquim Borba‐Pinheiro, Rodrigo Gomes de Souza Vale   +4 more
wiley   +1 more source

CSF1 regulates inflammation and apoptosis in intervertebral disc degeneration. [PDF]

Sci Rep
Zhang F, Wu W, Yuan Y, Wang Y, Zhang W.
europepmc   +1 more source

Global Workflow of a Comanipulation‐Based Robotic System for Cervical Spine Surgery

The International Journal of Medical Robotics and Computer Assisted Surgery, Volume 22, Issue 3, June 2026.
ABSTRACT Background Cervical arthrodesis requires precise pedicle screw placement to ensure safety and effectiveness. Traditional planning and execution are time‐consuming and prone to variability. Methods We developed a robot‐assisted system integrating three components: an AI‐based preoperative planning module, adapted from previous work, to generate
A. Koszulinski, J. Sandoval, C.‐T. Wu, S.‐H. Huang, S. K. Sahani, S.‐L. Wu, T. Essomba, T. Vendeuvre, J.‐P. Faure, S. Zeghloul, M. A. Laribi   +10 more
wiley   +1 more source

Metabolic reprogramming in intervertebral disc degeneration: mechanisms and therapeutic opportunities. [PDF]

Front Cell Dev Biol
Lu Q, He C.
europepmc   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, Volume 7, Issue 3, June 2026.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Epigenetic research methods and animal models for intervertebral disc degeneration (Review). [PDF]

Mol Med Rep
Cui X, Zeng L, Zhang W, Xi L, Wang R, Jia D, Safa, Feng H, Jia H.   +8 more
europepmc   +1 more source

Abnormal Stress Reduced miR‐330 Supplementation Alleviates Osteoarthritis Progression by Suppressing Osteochondral Catabolism

Aging Cell, Volume 25, Issue 6, June 2026.
Downregulation of miR‐330 under abnormal stress exacerbates catabolism in cartilage and subchondral bone, thereby promoting the progression of osteoarthritis. ABSTRACT Abnormal mechanical stress plays a crucial role in the progression of osteoarthritis (OA). Key factors regulating mechanical response remain to be explored. This study harvested synovium
Luxiang Zou, Kaiwen Yang, Chuyao Wang, Yeke Yu, Xiaoyu Zhang, Chuan Lu, Jieyun Zhao, An Qin, Dongmei He   +8 more
wiley   +1 more source

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration

Aging Cell, Volume 25, Issue 6, June 2026.
Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu, Yuanyuan Lai, Chunhui Tian, Yufei Huang, Jianheng Hao, Yuemeng Zhao, Dan Chen, Tianyu Wu, Daqian Zhou, Xiaoyan Zheng, Han Yang, Zheng Yu, Nihong Li, Jie Yang   +13 more
wiley   +1 more source

Research on the mechanism of Duhuo in treating intervertebral disc degeneration based on bioinformatics and network pharmacology. [PDF]

Medicine (Baltimore)
Yan Q, Liu F, Xu Z, Zhang C, Yang L, Wu X, Jiang C, Chen F, Li Z.   +8 more
europepmc   +1 more source