Results 271 to 280 of about 38,647 (321)

Influence of Posterior Decompression for Lumbar Spinal Canal Stenosis on Intervertebral Disc Degeneration on Magnetic Resonance Imaging. [PDF]

Cureus
Kamei N, Nakamae T, Adachi N.
europepmc   +1 more source

An enzyme-proof glycan glue for extracellular matrix to ameliorate intervertebral disc degeneration. [PDF]

Nat Commun
Liu Y, Chao T, Li Y, Peng P, Ge G, Geng D, Dong L, Wang C.   +7 more
europepmc   +1 more source

Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration. [PDF]

J Orthop Translat
Wang H, Liu X, Jing X, Zhang B, Liu X, Liu X, Jia F, Su C, Wang W, Cui X.   +9 more
europepmc   +1 more source

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Genetics of Intervertebral Disc Degeneration

Current Osteoporosis Reports, 2023
Intervertebral disc degeneration is a contributor to chronic back pain. While a part of the natural aging process, early or rapid intervertebral disc degeneration is highly heritable. In this review, we summarize recent progress towards unraveling the genetics associated with this degenerative process.Use of large cohorts of patient data to conduct ...
David C. Ou-Yang, Christopher J. Kleck, Cheryl L. Ackert-Bicknell   +2 more
openaire   +2 more sources

Fundamentals of Intervertebral Disc Degeneration

World Neurosurgery, 2022
Lumbar disc degeneration is one of the leading causes of chronic low back pain. The degenerative cascade is often initiated by an imbalance between catabolic and anabolic processes in the intervertebral discs. As a consequence of extracellular matrix degradation, neoinnervation and neovascularization take place.
Sertac Kirnaz, Charisse Capadona, Taylor Wong, Jacob L. Goldberg, Branden Medary, Fabian Sommer, Lynn B. McGrath, Roger Härtl   +7 more
openaire   +2 more sources

Intervertebral disc degeneration

European Spine Journal, 1993
Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement
Barrie Vernon-Roberts, Robert D. Fraser, O. L. Osti   +2 more
openaire   +3 more sources

Smoking and intervertebral disc degeneration

Medical Hypotheses, 2001
Cigarette smokers have an increased risk of low back pain which may be caused by disc degeneration and spinal instability, for example. Ischemia, apoptosis, faulty synthesis of disc macromolecules, and an imbalance between disc matrix proteinases and their inhibitors may be involved in the pathogenesis of disc degeneration. Along with degeneration, the
R.R. Fogelholm, A.V.Alho
openaire   +3 more sources

Genetics of the Degenerated Intervertebral Disc

World Neurosurgery, 2012
Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes.
Nikolay L. Martirosyan, Guy G. Broc, Nicholas Theodore, Samuel Kalb, M. Yashar S. Kalani   +4 more
openaire   +3 more sources