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MMPs and ADAMTSs in intervertebral disc degeneration
Clinica Chimica Acta, 2015Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with low back pain, a leading cause of musculoskeletal disability worldwide. The major components of extracellular matrix (ECM) within the discs are type II collagen (Col II) and aggrecan.
Xiao-Hua Yu +7 more
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Genetic aspects of intervertebral disc degeneration
Reviews in the Neurosciences, 2015Abstract Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could ...
Sina Abdollahzade +4 more
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Biochemical changes in intervertebral disc degeneration
Biochimica et Biophysica Acta (BBA) - General Subjects, 1981The distribution of the principal matrix components, collagen, proteoglycans and water, across the diameter of human normal and degenerate intervertebral discs was compared. Little difference in collagen distribution was noted between normal and degenerate tissue but water and proteoglycan content decreased with degeneration, particularly in the centre
S.M. Eisenstein +2 more
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Aging and Degeneration in the Lumbar Intervertebral Disc
Orthopedic Clinics of North America, 19771. The maintenance of the nucleus pulposus matrix in the adult human disc is dependent on the functional integrity of the cartilage end plate cells. 2. Cartilage end plate senescence is followed by compensatory cartilaginous metaplasia of annulus fibrosus cells. 3.
Kenneth P.H. Pritzker +1 more
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Molecular basis of intervertebral disc degeneration
The Spine Journal, 2004This review will acquaint the reader with normal development, structure, and function of the intervertebral disc. The disc is composed of the vertebral endplate, nucleus pulposus, and annulus fibrosus. These three functional components all serve important purposes for health and function of the disc. Nutrition and biomechanics are also discussed.
Matthew H. Walker, D. Greg Anderson
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Molecular Basis of Intervertebral Disc Degeneration
2012Intervertebral disc (IVD) degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to degeneration of the disc and surrounding area. Degeneration of the disc is considered to be a normal process of aging, but can accelerate faster than expected or be precipitated by other factors.
Amol Shah +3 more
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Mechanobiology in intervertebral disc degeneration and regeneration
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005The intervertebral disc is an avascular, pliant, composite structure that separates spinal vertebrae and, in health, serves to support compression and facilitate movement. Its morphological organization is directed by fluid pressure and consists of a central swelling gel (nucleus), surrounded peripherally by a constraining ligament (annulus fibrosus ...
Adam H. Hsieh +3 more
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Mechanical Initiation of Intervertebral Disc Degeneration
Spine, 2000Mechanical testing of cadaveric lumbar motion segments.To test the hypothesis that minor damage to a vertebral body can lead to progressive disruption of the adjacent intervertebral disc.Disc degeneration involves gross structural disruption as well as cell-mediated changes in matrix composition, but there is little evidence concerning which comes ...
Helen P. Morrison +4 more
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Aging and Degeneration of the Human Intervertebral Disc
Spine, 1995Human intervertebral discs undergo age-related degenerative changes that contribute to some of the most common causes of impairment and disability for middle aged and older persons: spine stiffness, neck pain, and back pain. Potential causes of the age-related degeneration of intervertebral discs include declining nutrition, loss of viable cells, cell ...
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Cell death in intervertebral disc degeneration
Apoptosis, 2013Degeneration of intervertebral disc (IVD) is mainly a chronic process of excessive destruction of the extracellular matrix (ECM), and also is thought to be the primary cause of low back pain. Presently, however, the underlying mechanism of IVD degeneration is still not elucidated.
Li-ming Xiong, Fan Ding, Zengwu Shao
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