Intervertebral disk regeneration in a rat model by allopurinol–loaded chitosan/alginate hydrogel [PDF]
Biomolecules & Biomedicine, 2023 Intervertebral disk degeneration remains one of the most challenging health problems. In the current study, allopurinol was loaded into the chitosan nanoparticles and then incorporated into chitosan/alginate hydrogels and then further studied for its ...
Linhui Ye, Zengxin Gao, Saeed Rohani
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Advances and Prospects in Biomaterials for Intervertebral Disk Regeneration [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Low-back and neck-shoulder pains caused by intervertebral disk degeneration are highly prevalent among middle-aged and elderly people globally. The main therapy method for intervertebral disk degeneration is surgical intervention, including interbody ...
Chunxu Li +6 more
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Influence of Age and Gender on Intervertebral Disk Degeneration and Height in the Thoracolumbar Spine [PDF]
Spine Surgery and Related Research, 2022 Introduction: Intervertebral disk degeneration is a universal and natural process. However, no reports have summarized anatomical age-related intervertebral disk height and disk degenerative changes in the thoracolumbar spine or examined sex-specific ...
Masaaki Machino +6 more
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Decoding Macrophage Subtypes to Engineer Modulating Hydrogels for the Alleviation of Intervertebral Disk Degeneration [PDF]
Advanced ScienceA major pathological basis for low back pain is intervertebral disk degeneration, which is primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism.
Da‐Wang Zhao +7 more
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Case report: Clinical and pathological findings in a canine patient with intervertebral disk extrusion resembling progressive myelomalacia [PDF]
Frontiers in Veterinary Science, 2023 A 4-year-old female spayed dog presented to the emergency department for non-ambulatory tetraparesis, which progressed to tetraplegia. Computed tomography (CT) confirmed cervical intervertebral disk extrusion at C5-6 extending to C6-7, and an emergency ...
Annie Lin +4 more
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Therapeutic effect and mechanism of Yougui Wan in rats with intervertebral disk degeneration [PDF]
Journal of Orthopaedic Surgery and ResearchObjective To explore the potential mechanism of Yougui Wan on deformed lumbar intervertebral disk structure in rats. Methods Thirty male Sprague–Dawley rats were randomly divided into 3 groups, with 10 rats in each group. The animals in the blank control
She Ma +4 more
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On the suitability of additively manufactured gyroid structures and their potential use as intervertebral disk replacement - a feasibility study [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionIntervertebral disk degeneration is a growing problem in our society. The degeneration of the intervertebral disk leads to back pain and in some cases to a herniated disk.
Valentin Gross +7 more
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Case series: Cervical far-lateral and combined cervical far lateral/foraminal intervertebral disk extrusions in 10 dogs [PDF]
Frontiers in Veterinary ScienceFar-lateral intervertebral disk extrusions (IVDEs) have been reported infrequently in dogs in veterinary literature, mostly affecting the caudal lumbar intervertebral disks.
Koen M. Santifort +15 more
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Overexpression of BNIP3 in rat intervertebral disk cells triggers autophagy and apoptosis [PDF]
Archives of Biological Sciences, 2022 Excessive apoptosis of intervertebral disk cells and intervertebral disk degeneration (IDD) is the prime cause of low back pain. B-cell lymphoma 2 (Bcl-2) and adenovirus E1B 19 kDa interacting protein 3 (BNIP3), a member of the Bcl-2 family, are involved
Tingsheng Wu +5 more
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