Advances and Prospects in Biomaterials for Intervertebral Disk Regeneration [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Low-back and neck-shoulder pains caused by intervertebral disk degeneration are highly prevalent among middle-aged and elderly people globally. The main therapy method for intervertebral disk degeneration is surgical intervention, including interbody ...
Chunxu Li +6 more
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Intervertebral disk regeneration in a rat model by allopurinol–loaded chitosan/alginate hydrogel [PDF]
Biomolecules & Biomedicine, 2023 Intervertebral disk degeneration remains one of the most challenging health problems. In the current study, allopurinol was loaded into the chitosan nanoparticles and then incorporated into chitosan/alginate hydrogels and then further studied for its ...
Linhui Ye, Zengxin Gao, Saeed Rohani
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Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain
Global Spine Journal, 2013 Although degeneration of the intervertebral disk has historically been described as a misbalance between anabolic and catabolic factors, the role of inflammatory mediators has long been neglected.
Karin Wuertz, Lisbet Haglund
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Decoding Macrophage Subtypes to Engineer Modulating Hydrogels for the Alleviation of Intervertebral Disk Degeneration [PDF]
Advanced ScienceA major pathological basis for low back pain is intervertebral disk degeneration, which is primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism.
Da‐Wang Zhao +7 more
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Therapeutic effect and mechanism of Yougui Wan in rats with intervertebral disk degeneration [PDF]
Journal of Orthopaedic Surgery and ResearchObjective To explore the potential mechanism of Yougui Wan on deformed lumbar intervertebral disk structure in rats. Methods Thirty male Sprague–Dawley rats were randomly divided into 3 groups, with 10 rats in each group. The animals in the blank control
She Ma +4 more
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The Role of Trabecular, Ligamentous-Intervertebral Disk and Facet Joints Systems: A Finite Element Analysis in the L4-S1 Vertebrae [PDF]
Global Spine JournalStudy Design Descriptive. Objectives Trabecular bone in the vertebrae is critical for the distribution of load and stress throughout the neuroaxis, as well as the intervertebral disk, ligamentous complex, and facet joints. The objective was to assess the
José Alejandro Guerrero-Vargas PhD +5 more
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Overexpression of BNIP3 in rat intervertebral disk cells triggers autophagy and apoptosis [PDF]
Archives of Biological Sciences, 2022 Excessive apoptosis of intervertebral disk cells and intervertebral disk degeneration (IDD) is the prime cause of low back pain. B-cell lymphoma 2 (Bcl-2) and adenovirus E1B 19 kDa interacting protein 3 (BNIP3), a member of the Bcl-2 family, are involved
Tingsheng Wu +5 more
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Spine Surgery and Related Research, 2022 Introduction: Intervertebral disk degeneration is a universal and natural process. However, no reports have summarized anatomical age-related intervertebral disk height and disk degenerative changes in the thoracolumbar spine or examined sex-specific ...
Masaaki Machino +6 more
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Semi-automated spine and intervertebral disk detection and segmentation from whole spine MR images
Informatics in Medicine Unlocked, 2021 Intervertebral disks are found between the vertebrae in the spine from the second cervical vertebra to the sacrum. Intervertebral disks permit various movements of the vertebral column to keep it flexible and to absorb vertical shock.
Alaa Badarneh +3 more
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Clinical Practice and Cases in Emergency Medicine, 2021 Case Presentation: A five-year-old boy presented to our emergency department with severe posterior neck pain that was exacerbated upon neck movement. Cervical spine radiography revealed calcification in the cervical intervertebral disk 3–4.
Hirofumi Ohno +4 more
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