Results 1 to 10 of about 14,963 (141)
Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain [PDF]
Global Spine Journal, 2013 Although degeneration of the intervertebral disk has historically been described as a misbalance between anabolic and catabolic factors, the role of inflammatory mediators has long been neglected.
Karin Wuertz PhD, Lisbet Haglund PhD
doaj +4 more sources
Decoding Macrophage Subtypes to Engineer Modulating Hydrogels for the Alleviation of Intervertebral Disk Degeneration [PDF]
Advanced ScienceA major pathological basis for low back pain is intervertebral disk degeneration, which is primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism.
Da‐Wang Zhao +7 more
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Intervertebral Disk Degeneration: The Microenvironment and Tissue Engineering Strategies [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Intervertebral disk degeneration (IVDD) is a leading cause of disability. The degeneration is inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on the relief of symptoms, not the intrinsic regeneration of the ...
Yiming Dou +4 more
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Mechanisms of Intervertebral Disk Degeneration/Injury and Pain: A Review [PDF]
Global Spine Journal, 2013 Degeneration of the intervertebral disk and its treatments are currently intensely investigated topics. Back pain is a condition whose chronic and debilitating nature combined with its prevalence make it a major health issue of substantial socioeconomic ...
Keita Ito MD, ScD, Laura Creemers
doaj +5 more sources
MiR-206 improves intervertebral disk degeneration by targeting GJA1 [PDF]
Journal of Orthopaedic Surgery and Research, 2022 Background A large amount of evidence suggested that miRNA was involved in the progression of intervertebral disk degeneration (IDD). The purpose of our study was to explore the function and potential mechanism of miR-206/GJA1 axis in IDD.
Peng Zhou, Peng Xu, Wantao Yu, Huan Li
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Influence of Age and Gender on Intervertebral Disk Degeneration and Height in the Thoracolumbar Spine [PDF]
Spine Surgery and Related Research, 2022 Introduction: Intervertebral disk degeneration is a universal and natural process. However, no reports have summarized anatomical age-related intervertebral disk height and disk degenerative changes in the thoracolumbar spine or examined sex-specific ...
Masaaki Machino +6 more
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Mechanobiology of MicroRNAs in Intervertebral Disk Degeneration. [PDF]
J Spine Res Surg, 2023 Intervertebral disk degeneration (IDD) is an intricate pathological process contributing to one of the major causes of low back pain. The degradation of the extracellular matrix (ECM), inflammation, and apoptosis have all been investigated as critical factors involved in the pathology of degenerative disk disease. Additionally, the presence of aberrant
Supra R, Agrawal DK.
europepmc +3 more sources
Circular RNAs in compression-induced intervertebral disk degeneration [PDF]
EBioMedicine, 2020 Ximiao Chen, Mingbao Gu, Xiaolei Zhang
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Biomechanics of Intervertebral Disk Degeneration [PDF]
Orthopedic Clinics of North America, 2011 Degenerative changes in the material properties of nucleus pulposus and anulus fibrosus promote changes in viscoelastic properties of the whole disc. Volume, pressure and hydration loss in the nucleus pulposus, disk height decreases and fissures in the anulus fibrosus, are some of the signs of the degenerative cascade that advances with age and affect,
Nozomu Inoue +1 more
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Tissue Engineering for Intervertebral Disk Degeneration [PDF]
Orthopedic Clinics of North America, 2011 Many challenges confront intervertebral disk engineering owing to complexity and the presence of extraordinary stresses. Rebuilding a disk of native function could be useful for removal of the symptoms and correction of altered spine kinematics. Improvement in understanding of disk properties and techniques for disk engineering brings promise to the ...
Victor Y L Leung, Vivian Tam, Danny Chan
exaly +5 more sources