Results 31 to 40 of about 14,963 (141)

Molecular Therapy for Disk Degeneration and Pain

Global Spine Journal, 2013
The nucleus pulposus of the intervertebral disk contains high amounts of the proteoglycan aggrecan, which confers the disk with a remarkable ability to resist compression. Other molecules such as collagens and noncollagenous proteins in the extracellular
Fackson Mwale PhD
doaj   +1 more source

Efficacy and Safety of Condoliase Disc Administration as a New Treatment for Lumbar Disc Herniation

Spine Surgery and Related Research, 2022
Introduction: Condoliase is a newly approved drug that improves symptoms associated with lumbar disk herniation (LDH) by intradiscal administration. This study aimed to evaluate the mid-term outcomes of condoliase injection, examine the adverse events ...
Masahiro Inoue, Takeshi Sainoh, Atsushi Kojima, Masatsune Yamagata, Tatsuo Morinaga, Chikato Mannoji, Hiromi Ataka, Masaomi Yamashita, Hiroshi Takahashi, Junya Saito, Takayuki Fujiyoshi, Tetsuhiro Ishikawa, Yawara Eguchi, Kei Kato, Sumihisa Orita, Kazuhide Inage, Yasuhiro Shiga, Masaki Norimoto, Tomotaka Umimura, Yuki Shiko, Yohei Kawasaki, Yasuchika Aoki, Seiji Ohtori   +22 more
doaj   +1 more source

Evaluating the Impact of Mechanical Manipulation on Inducing Disk Degeneration: A 3-Month Radiologic Follow-Up of Intervertebral Disk Degeneration in a Needle-Punctured Rat Tail Model

Global Spine Journal, 2012
Introduction The rat tail model for the intervertebral disk degeneration has recently been receiving a high level of interest among the intervertebral disk degeneration studies.
R. Härtl, M. Alimi, M. Macielak, A. James, P. Grunert, J. Tsiouris, L. Bonassar   +6 more
doaj   +1 more source

Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor

Molecular Therapy: Nucleic Acids, 2019
Intervertebral disk (IVD) degeneration is often associated with severity of lower back pain. IVD core is an avascular, highly hydrated tissue composed of type II collagen, glycosaminoglycans, and proteoglycans.
Chin-Yu Lin, Samuel Thomas Crowley, Satoshi Uchida, Yuji Komaki, Kazunori Kataoka, Keiji Itaka   +5 more
doaj   +1 more source

Sericin/crocetin micro/nanoparticles for nucleus pulposus cells regeneration: An “active” drug delivery system

Frontiers in Pharmacology, 2023
Introduction: Initiation and progression of intervertebral disk degeneration are linked to oxidative stress, with reactive oxygen species being a key factor.
Elia Bari, Sara Perteghella, Giovanna Rassu, Elisabetta Gavini, Giacomo Luigi Petretto, Maria Cristina Bonferoni, Paolo Giunchedi, Maria Luisa Torre   +7 more
doaj   +1 more source

Clinical and magnetic resonance imaging characterization of cervical spondylomyelopathy in juvenile dogs

Journal of Veterinary Internal Medicine, 2019
Background Cervical spondylomyelopathy (CSM) occurs because of compression of the cervical spinal cord, nerve roots, or both, usually affecting young adult to older large and giant breed dogs. Juvenile dogs are affected infrequently.
Marília de AlbuquerqueBonelli, Ronaldo C. daCosta   +1 more
doaj   +1 more source

Intervertebral Disk Degeneration is not a Direct Cause of Pain Behavior: An Experimental Study Using a Disk Puncture Model in Rats

Global Spine Journal, 2012
Introduction Low back pain (LBP) is a common symptom in patients with lumbar diseases. But the relationship between lumbar intervertebral disk degeneration and LBPis still a controversial issue. Some animal models were used to discuss this issue in prior
Z. Zheng, H. Liu, Z. Li, J. Wang, H. Yang, S. S. Sribastav   +5 more
doaj   +1 more source

Emerging Technologies for Molecular Therapy for Intervertebral Disk Degeneration [PDF]

Orthopedic Clinics of North America, 2011
Intervertebral disks are biologically regulated by the maintenance of a balance between the anabolic and catabolic activities of disk cells. Therapeutic agents, initially evaluated using in vitro studies on disk cells and explants, have been used as intradiscal injections in preclinical settings to test in vivo efficacy.
Won C, Bae, Koichi, Masuda
openaire   +2 more sources

Does Erythropoietin and Its Receptor may Play a Role in Human Intervertebral Disk Degeneration?

Global Spine Journal, 2012
Introduction Degeneration of lumbar intervertebral discs is considered to be a cause of low back pain and radiculopathy. Many studies have shown that intervertebral disk inflammation and axonal growth of afferent fibers innervating the disk degeneration ...
G. Grasso, F. Certo, A. G. Pirrone, D. Iacopino   +3 more
doaj   +1 more source

Cartilage Endplate and its Role in Disk Degeneration (Analytical Review of the Literature)

Bolʹ, Sustavy, Pozvonočnik, 2012
This review summarizes the current literature data on the structure and function of the cartilage endplate in humans and animals. Age aspect of the cartilage endplate changes and its disturbances in disk degeneration is presented.
L.M. Bengus, N.V. Dedukh
doaj   +1 more source