Results 41 to 50 of about 14,963 (141)

Deciphering the sequential changes of monocytes/macrophages in the progression of IDD with longitudinal approach using single-cell transcriptome

Frontiers in Immunology, 2023
Intervertebral disk degeneration (IDD) is a chronic inflammatory disease with intricate connections between immune infiltration and oxidative stress (OS).
Weihang Li, Yingjing Zhao, Yongchun Wang, Zhijian He, Linyuan Zhang, Bin Yuan, Chengfei Li, Zhuojing Luo, Bo Gao, Ming Yan   +9 more
doaj   +1 more source

Intervertebral disk regeneration in a rat model by allopurinol–loaded chitosan/alginate hydrogel

Biomolecules & Biomedicine, 2023
Intervertebral disk degeneration remains one of the most challenging health problems. In the current study, allopurinol was loaded into the chitosan nanoparticles and then incorporated into chitosan/alginate hydrogels and then further studied for its ...
Linhui Ye, Zengxin Gao, Saeed Rohani
doaj   +1 more source

Changes in Intervertebral Disk Mechanical Behavior During Early Degeneration

Journal of Biomechanical Engineering, 2018
Intervertebral disk (IVD) degeneration is commonly described by loss of height and hydration. However, in the first stage of IVD degeneration, this loss has not yet occurred. In the current study, we use an ex vivo degeneration model to analyze the changes in IVDs mechanical behavior in the first phase of degeneration.
Paul, Cornelis P. L., Emanuel, Kaj S., Kingma, Idsart, van der Veen, Albert J., Holewijn, Roderick M., Vergroesen, Pieter-Paul A., van de Ven, Peter M., Mullender, Margriet G., Helder, Marco N., Smit, Theodoor H.   +9 more
openaire   +4 more sources

Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

Journal of Orthopaedic Surgery and Research, 2021
Background Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration (IVDD) development is apoptosis of
Qi Sun, Xin-Yu Nan, Fa-Ming Tian, Fang Liu, Shao-Hua Ping, Zhuang Zhou, Liu Zhang   +6 more
doaj   +1 more source

Clinical Practice Guidelines for Herniated Disk Treatment

Medisur, 2009
Clinical Practice Guidelines for Herniated Disk Treatment. The current concept is not only limited to the disorder caused by the rupture of the intervertebral disk, it also includes primary disk degeneration and the resulting spondylosis, and disk ...
José Ramón Tejera del Valle, Joaquín Aguilar Trujillo, Danny Barrueta Reyes, José Gómez Cruz, Líder Tejera Sánchez   +4 more
doaj   +2 more sources

Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration

APL Materials
Intervertebral disk degeneration (IVDD) is a major cause of spinal pathology and pain and can lead to disability in adults in severe cases. The medication against disk degeneration is limited due to the lack of therapeutic drugs and ineffective delivery ...
Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tao Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao   +11 more
doaj   +1 more source

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Nature Communications, 2018
Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity.
Ming-liang Ji, Hua Jiang, Xue-jun Zhang, Pei-liang Shi, Chao Li, Hao Wu, Xiao-tao Wu, Yun-tao Wang, Chen Wang, Jun Lu   +9 more
doaj   +1 more source

Alkaptonuric patient presenting with “black” disc: a case report

Acta Orthopaedica et Traumatologica Turcica, 2020
Although intervertebral disc degeneration usually occurs in the natural course of alkaptonuria, detection of the disease by black disc material in a patient without any other sign of alkaptonuria is an extremely rare condition.
Ramazan Kahveci, Mehmet Fikret Ergungor, Ahmet Gunaydin, Atiye Temiz   +3 more
doaj   +1 more source

Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus

Advanced Science, 2020
Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels.
Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, Lianfu Deng, Wenguo Cui, Yuhui Zhang, Hélder A. Santos, Hongxing Shen   +8 more
doaj   +1 more source

Magnetic Resonance Imaging Signal Alterations in Paraspinal Muscles in Dogs with Acute Thoracolumbar Intervertebral Disk Extrusion

Frontiers in Veterinary Science, 2018
Muscle signal alteration detected on MRI is seen in diverse pathologic conditions. We observed signal alterations within the paraspinal muscles in dogs with acute thoracolumbar intervertebral disk extrusion.
Peter Trampus, Christine Goepfert, Monika Welle, Diana Henke, Franck Forterre, Daniela Schweizer-Gorgas   +5 more
doaj   +1 more source