Cytokine Imbalance as a Biomarker of Intervertebral Disk Degeneration [PDF]
International Journal of Molecular Sciences, 2023 The intervertebral disk degeneration (IDD) and its associated conditions are an important problem in modern medicine. The onset of IDD may be in childhood and adolescence in patients with a genetic predisposition.
Natalia Shnayder +2 more
exaly +5 more sources
Mechanobiology of MicroRNAs in Intervertebral Disk Degeneration. [PDF]
J Spine Res Surg, 2023 Intervertebral disk degeneration (IDD) is an intricate pathological process contributing to one of the major causes of low back pain. The degradation of the extracellular matrix (ECM), inflammation, and apoptosis have all been investigated as critical ...
Supra R, Agrawal DK.
europepmc +4 more sources
Influence of Age and Gender on Intervertebral Disk Degeneration and Height in the Thoracolumbar Spine [PDF]
Spine Surgery and Related Research, 2022 Introduction: Intervertebral disk degeneration is a universal and natural process. However, no reports have summarized anatomical age-related intervertebral disk height and disk degenerative changes in the thoracolumbar spine or examined sex-specific ...
Masaaki Machino +6 more
doaj +3 more sources
Decoding Macrophage Subtypes to Engineer Modulating Hydrogels for the Alleviation of Intervertebral Disk Degeneration [PDF]
Advanced Science, 2023 A major pathological basis for low back pain is intervertebral disk degeneration, which is primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism.
Da‐Wang Zhao +7 more
doaj +3 more sources
Exosomes derived from human urine–derived stem cells ameliorate IL-1β-induced intervertebral disk degeneration [PDF]
BMC Musculoskeletal DisordersBackground Human intervertebral disk degeneration (IVDD) is a sophisticated degenerative pathological process. A key cause of IVDD progression is nucleus pulposus cell (NPC) degeneration, which contributes to excessive endoplasmic reticulum stress in the
Guang Qian +4 more
doaj +3 more sources
Mechanisms of Intervertebral Disk Degeneration/Injury and Pain: A Review [PDF]
Global Spine Journal, 2013 Degeneration of the intervertebral disk and its treatments are currently intensely investigated topics. Back pain is a condition whose chronic and debilitating nature combined with its prevalence make it a major health issue of substantial socioeconomic ...
Laura Creemers, Keita Itô
exaly +5 more sources
An Automatized Deep Segmentation and Classification Model for Lumbar Disk Degeneration and Clarification of Its Impact on Clinical Decisions. [PDF]
Global Spine J, 2023 Study Design Cross-sectional database study Objective The purpose of this study was to develop a successful, reproducible, and reliable convolutional neural network (CNN) model capable of segmentation and classification for grading intervertebral disc ...
Soydan Z +5 more
europepmc +3 more sources
Intervertebral Disk Degeneration and Bone Mineral Density: A Bidirectional Mendelian Randomization Study. [PDF]
Calcif Tissue Int, 2023 This study aimed to investigate the causal relationship between bone mineral density (BMD) and intervertebral disk degeneration (IVDD) using a two-sample bidirectional Mendelian randomization analysis.
Zhao J +7 more
europepmc +2 more sources
Current status and development direction of immunomodulatory therapy for intervertebral disk degeneration. [PDF]
Front Med (Lausanne), 2023 Intervertebral disk (IVD) degeneration (IVDD) is a main factor in lower back pain, and immunomodulation plays a vital role in disease progression. The IVD is an immune privileged organ, and immunosuppressive molecules in tissues reduce immune cell ...
Gao Y +5 more
europepmc +2 more sources
Disk Degeneration and Pain [PDF]
Global Spine Journal, 2013 It has been our sincerest honor to have guest-edited this focus issue on “Disk Degeneration and Pain” for the Global Spine Journal. Of particular importance is that this issue commemorates the “first” focus issue of our newly developed journal, which we hope will be one of many more to come.
Dino Samartzis +2 more
doaj +4 more sources