Results 11 to 20 of about 778,589 (272)

Lipid metabolic disorders and their impact on cartilage endplate and nucleus pulposus function in intervertebral disk degeneration. [PDF]

Front Nutr
Lipid metabolism encompasses the processes of digestion, absorption, synthesis, and degradation of fats within biological systems, playing a crucial role in sustaining normal physiological functions.
Wu R, Zhao XJ, Du Y, Dong Y, Song X, Zhu Y.   +5 more
europepmc   +2 more sources

Silk fibroin-collagen hydrogel loaded with IGF1-CESCs attenuates intervertebral disk degeneration by accelerating annulus fibrosus healing in rats. [PDF]

Front Pharmacol
Introduction: The self-healing capacity of a damaged annulus fibrosus (AF) leads to intervertebral disk (IVD) degeneration. AF wound treatment is challenging.
Tian Z, Shen Z, Chen H, Zhao P.
europepmc   +2 more sources

Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice. [PDF]

Aging Cell
Age‐related intervertebral disk degeneration (IVDD) involves increased oxidative damage, cellular senescence, and matrix degradation. Pyrroloquinoline quinone (PQQ) is a water‐soluble vitamin‐like compound with strong anti‐oxidant capacity.
Xue Q, Li J, Qin R, Li M, Li Y, Zhang J, Wang R, Goltzman D, Miao D, Yang R.   +9 more
europepmc   +2 more sources

tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells. [PDF]

J Orthop Surg Res, 2023
Background Intervertebral disk degeneration (IDD) is a degenerative disease that underlies various musculoskeletal and spinal disorders and is positively correlated with age. tRNA-derived small RNAs (tsRNA), as a new small noncoding RNAs, its function in
Pan J, Liu Z, Shen B, Xu J, Dai G, Xu W, Wang J, Li L, Cheng L.   +8 more
europepmc   +2 more sources

How Should We Grade Cervical Disk Degeneration? A Comparison of Two Popular Classification Systems

Spine Surgery and Related Research, 2021
Introduction: Despite being originally developed for the evaluation of lumbar disk degeneration, the Pfirrmann classification has emerged as the most popular classification system for cervical disk degeneration. However, with the Suzuki classification, a
Lukas Urbanschitz, Susanne Bensler, Sascha Merat, Christopher Lenz, Karim Eid   +4 more
doaj   +2 more sources

The Role of Microvascular Variations in the Process of Intervertebral Disk Degeneration and Its Regulatory Mechanisms: A Literature Review. [PDF]

Orthop Surg
Microvascular changes are considered key factors in the process of intervertebral disk degeneration (IDD). Microvascular invasion and growth into the nucleus pulposus (NP) and cartilaginous endplates are unfavorable factors that trigger IDD. In contrast,
Zhang SP, Tong M, Li SD, Zhang B, Zhang W, Wang R, Dong ZY, Huang YF.   +7 more
europepmc   +2 more sources

Hsa_circ_0001946 Ameliorates Mechanical Stress-induced Intervertebral Disk Degeneration Via Targeting miR-432-5p and SOX9. [PDF]

Spine (Phila Pa 1976), 2023
Study Design. Experimental analysis of circular RNA in intervertebral disk degeneration (IDD). Objective. This study aimed to explore the roles of hsa_circ_0001946 (circ-CDR1as) in mechanical stress-induced nucleus pulposus cell injury in IDD. Summary of
Xiang Q, Wang J, Cheng Z, Zhao K, Gan W, Chen Y, Zhang Y.   +6 more
europepmc   +2 more sources

Intervertebral Disk Degeneration: The Microenvironment and Tissue Engineering Strategies. [PDF]

Front Bioeng Biotechnol, 2021
Intervertebral disk degeneration (IVDD) is a leading cause of disability. The degeneration is inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on the relief of symptoms, not the intrinsic regeneration of the ...
Dou Y, Sun X, Ma X, Zhao X, Yang Q.
europepmc   +2 more sources

Biomechanics of Intervertebral Disk Degeneration [PDF]

Orthopedic Clinics of North America, 2011
Degenerative changes in the material properties of nucleus pulposus and anulus fibrosus promote changes in viscoelastic properties of the whole disc. Volume, pressure and hydration loss in the nucleus pulposus, disk height decreases and fissures in the anulus fibrosus, are some of the signs of the degenerative cascade that advances with age and affect,
Alejandro A Espinoza Orias, Nozomu Inoue   +1 more
exaly   +3 more sources

MiR-206 improves intervertebral disk degeneration by targeting GJA1. [PDF]

J Orthop Surg Res, 2022
Background A large amount of evidence suggested that miRNA was involved in the progression of intervertebral disk degeneration (IDD). The purpose of our study was to explore the function and potential mechanism of miR-206/GJA1 axis in IDD.
Zhou P, Xu P, Yu W, Li H.
europepmc   +2 more sources