Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration. [PDF]
BiomacromoleculesIntervertebral disk degeneration is a common disease with an unknown etiology. Currently, tissue engineering is considered to be an important method for intervertebral disk repair.
Fang Y +5 more
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Intervertebral Disk Degeneration and Repair
Neurosurgery, 2017 Intervertebral disk (IVD) degeneration is a natural progression of the aging process. Degenerative disk disease (DDD) is a pathologic condition associated with IVD that has been associated with chronic back pain.
James E. Dowdell +5 more
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Association of Paraspinal Muscle CSA and PDFF Measurements With Lumbar Intervertebral Disk Degeneration in Patients With Chronic Low Back Pain. [PDF]
Front Endocrinol (Lausanne), 2022 There is an interaction between the lumbar spine and paraspinal muscles, which may play a role in the development of intervertebral disc (IVD) degeneration and may affect CLBP.
Huang Y +8 more
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Tissue Engineering for Intervertebral Disk Degeneration [PDF]
Orthopedic Clinics of North America, 2011 Many challenges confront intervertebral disk engineering owing to complexity and the presence of extraordinary stresses. Rebuilding a disk of native function could be useful for removal of the symptoms and correction of altered spine kinematics. Improvement in understanding of disk properties and techniques for disk engineering brings promise to the ...
Bp Chan, Kenneth Cheung, Vivian Tam
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Changes in the composition of the fecal metabolome and gut microbiota contribute to intervertebral disk degeneration in a rabbit model. [PDF]
J Orthop Surg ResPurpose Lower back pain (LBP), mainly caused by intervertebral disk (IVD) degeneration (IDD), is widely prevalent worldwide and is a serious socioeconomic burden.
Cheng S, Yu J, Cui M, Su H, Cao Y.
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Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain
Global Spine Journal, 2013 Although degeneration of the intervertebral disk has historically been described as a misbalance between anabolic and catabolic factors, the role of inflammatory mediators has long been neglected.
Lisbet Haglund, Karin Wuertz-Kozak
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Molecular Therapy for Disk Degeneration and Pain [PDF]
Global Spine Journal, 2013 The nucleus pulposus of the intervertebral disk contains high amounts of the proteoglycan aggrecan, which confers the disk with a remarkable ability to resist compression. Other molecules such as collagens and noncollagenous proteins in the extracellular
Fackson Mwale PhD
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MiR-330-5p inhibits intervertebral disk degeneration via targeting CILP. [PDF]
J Orthop Surg Res, 2021 Background Intervertebral disk degeneration (IDD) is caused by nucleus pulposus (NP) degeneration and extracellular matrix (ECM) remodeling and cartilage intermediate layer protein (CILP) expression has been confirmed to be increased in IDD.
Li S, Liu J, Chen L.
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Melatonin Attenuates Intervertebral Disk Degeneration via Maintaining Cartilaginous Endplate Integrity in Rats. [PDF]
Front Physiol, 2021 Objective The aim of this study is to verify whether melatonin (Mel) could mitigate intervertebral disk degeneration (IVDD) in rats and to investigate the potential mechanism of it.
Wu X +11 more
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Academic RadiologyRATIONALE AND OBJECTIVES Lumbar disk degeneration is a common condition contributing significantly to back pain. The objective of the study was to evaluate the potential of dual-energy CT (DECT)-derived collagen maps for the assessment of lumbar disk ...
Scherwin Mahmoudi, Christoph Mader
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