Results 21 to 30 of about 16,112 (151)

Molecular Therapy for Disk Degeneration and Pain

Global Spine Journal, 2013
The nucleus pulposus of the intervertebral disk contains high amounts of the proteoglycan aggrecan, which confers the disk with a remarkable ability to resist compression. Other molecules such as collagens and noncollagenous proteins in the extracellular
Fackson Mwale PhD
doaj   +1 more source

Efficacy and Safety of Condoliase Disc Administration as a New Treatment for Lumbar Disc Herniation

Spine Surgery and Related Research, 2022
Introduction: Condoliase is a newly approved drug that improves symptoms associated with lumbar disk herniation (LDH) by intradiscal administration. This study aimed to evaluate the mid-term outcomes of condoliase injection, examine the adverse events ...
Masahiro Inoue, Takeshi Sainoh, Atsushi Kojima, Masatsune Yamagata, Tatsuo Morinaga, Chikato Mannoji, Hiromi Ataka, Masaomi Yamashita, Hiroshi Takahashi, Junya Saito, Takayuki Fujiyoshi, Tetsuhiro Ishikawa, Yawara Eguchi, Kei Kato, Sumihisa Orita, Kazuhide Inage, Yasuhiro Shiga, Masaki Norimoto, Tomotaka Umimura, Yuki Shiko, Yohei Kawasaki, Yasuchika Aoki, Seiji Ohtori   +22 more
doaj   +1 more source

Evaluating the Impact of Mechanical Manipulation on Inducing Disk Degeneration: A 3-Month Radiologic Follow-Up of Intervertebral Disk Degeneration in a Needle-Punctured Rat Tail Model

Global Spine Journal, 2012
Introduction The rat tail model for the intervertebral disk degeneration has recently been receiving a high level of interest among the intervertebral disk degeneration studies.
R. Härtl, M. Alimi, M. Macielak, A. James, P. Grunert, J. Tsiouris, L. Bonassar   +6 more
doaj   +1 more source

Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor

Molecular Therapy: Nucleic Acids, 2019
Intervertebral disk (IVD) degeneration is often associated with severity of lower back pain. IVD core is an avascular, highly hydrated tissue composed of type II collagen, glycosaminoglycans, and proteoglycans.
Chin-Yu Lin, Samuel Thomas Crowley, Satoshi Uchida, Yuji Komaki, Kazunori Kataoka, Keiji Itaka   +5 more
doaj   +1 more source

Sericin/crocetin micro/nanoparticles for nucleus pulposus cells regeneration: An “active” drug delivery system

Frontiers in Pharmacology, 2023
Introduction: Initiation and progression of intervertebral disk degeneration are linked to oxidative stress, with reactive oxygen species being a key factor.
Elia Bari, Sara Perteghella, Giovanna Rassu, Elisabetta Gavini, Giacomo Luigi Petretto, Maria Cristina Bonferoni, Paolo Giunchedi, Maria Luisa Torre   +7 more
doaj   +1 more source

Clinical and magnetic resonance imaging characterization of cervical spondylomyelopathy in juvenile dogs

Journal of Veterinary Internal Medicine, 2019
Background Cervical spondylomyelopathy (CSM) occurs because of compression of the cervical spinal cord, nerve roots, or both, usually affecting young adult to older large and giant breed dogs. Juvenile dogs are affected infrequently.
Marília de AlbuquerqueBonelli, Ronaldo C. daCosta   +1 more
doaj   +1 more source

Intervertebral Disk Degeneration is not a Direct Cause of Pain Behavior: An Experimental Study Using a Disk Puncture Model in Rats

Global Spine Journal, 2012
Introduction Low back pain (LBP) is a common symptom in patients with lumbar diseases. But the relationship between lumbar intervertebral disk degeneration and LBPis still a controversial issue. Some animal models were used to discuss this issue in prior
Z. Zheng, H. Liu, Z. Li, J. Wang, H. Yang, S. S. Sribastav   +5 more
doaj   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source