Antioxidative nanofullerol prevents intervertebral disk degeneration
International Journal of Nanomedicine, 2014 Xinlin Yang,1 Li Jin,1 Lu Yao,2,3 Francis H Shen,1 Adam L Shimer,1 Xudong Li11Orthopaedic Research Laboratories, University of Virginia, Charlottesville, VA, USA; 2School of Life Science, Beijing Institute of Technology, Beijing, People's Republic of
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Cytokine Imbalance as a Biomarker of Intervertebral Disk Degeneration. [PDF]
Int J Mol Sci, 2023 The intervertebral disk degeneration (IDD) and its associated conditions are an important problem in modern medicine. The onset of IDD may be in childhood and adolescence in patients with a genetic predisposition. IDD progresses with age, leading to spondylosis, spondylarthrosis, intervertebral disk herniation, and spinal stenosis.
Shnayder NA +7 more
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MiR-330-5p inhibits intervertebral disk degeneration via targeting CILP [PDF]
Journal of Orthopaedic Surgery and Research, 2021 Background Intervertebral disk degeneration (IDD) is caused by nucleus pulposus (NP) degeneration and extracellular matrix (ECM) remodeling and cartilage intermediate layer protein (CILP) expression has been confirmed to be increased in IDD.
Shangzhi Li, Jinwei Liu, Liang Chen
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Therapeutic effect and mechanism of Yougui Wan in rats with intervertebral disk degeneration [PDF]
Journal of Orthopaedic Surgery and ResearchObjective To explore the potential mechanism of Yougui Wan on deformed lumbar intervertebral disk structure in rats. Methods Thirty male Sprague–Dawley rats were randomly divided into 3 groups, with 10 rats in each group. The animals in the blank control
She Ma +4 more
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Low expression of miR-142-3p promotes intervertebral disk degeneration [PDF]
Journal of Orthopaedic Surgery and Research, 2021 Background Intervertebral disk degeneration (IDD) is a degenerative disease characterized by cytoplasm loss and extracellular matrix degradation. Numerous evidence reported that miRNAs participated in IDD development.
Jianmin Xue +8 more
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Exosomes derived from human urine–derived stem cells ameliorate IL-1β-induced intervertebral disk degeneration [PDF]
BMC Musculoskeletal DisordersBackground Human intervertebral disk degeneration (IVDD) is a sophisticated degenerative pathological process. A key cause of IVDD progression is nucleus pulposus cell (NPC) degeneration, which contributes to excessive endoplasmic reticulum stress in the
Guang Qian +4 more
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Gene Expression Profiling of Early Intervertebral Disk Degeneration
Global Spine Journal, 2012 Introduction Early degeneration of the IVD involves a change in the nucleus pulposus (NP) cell population, characterized by the replacement/differentiation of the native notochordal cells (NCs) by/into chondrocyte-like cells (CLCs).
L. Smolders +12 more
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Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration
Genomics, Proteomics & Bioinformatics, 2015 Intervertebral disk degeneration (IDD) is strongly associated with genetic predisposition and environmental susceptibility. Several studies been conducted to investigate the potential association between IDD and FokI polymorphism located in the gene ...
Jian Zhao +4 more
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Biomimetic Microstructural Materials for Intervertebral Disk Degeneration Repair
Small StructuresThe intervertebral disks (IVD) serve as shock absorbers in the spine. As the largest avascular tissue in the human body, it has a limited capacity for regeneration.
Ang Li +8 more
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Advances and Prospects in Biomaterials for Intervertebral Disk Regeneration
Frontiers in Bioengineering and Biotechnology, 2021 Low-back and neck-shoulder pains caused by intervertebral disk degeneration are highly prevalent among middle-aged and elderly people globally. The main therapy method for intervertebral disk degeneration is surgical intervention, including interbody ...
Chunxu Li +6 more
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