Results 31 to 40 of about 425,188 (323)

Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus

Advanced Science, 2020
Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels.
Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, Lianfu Deng, Wenguo Cui, Yuhui Zhang, Hélder A. Santos, Hongxing Shen   +8 more
doaj   +1 more source

Concept Development of a New Lumbar Intervertebral Disk Implant

MATEC Web of Conferences, 2017
Worldwide spinal cord injury incidence is rising, due to spikes in traffic incidences, violence and an increase in ageing population, prone to injuries. To satisfy an expanding market, a wide variety of spinal implantable devices are available.
Doicin Cristian-Vasile, Ulmeanu Mihaela-Elena, Frîncu Alexa-Sorina, Enache Vlad-Cristian   +3 more
doaj   +1 more source

Intervertebral Disk Degeneration and Repair.

Neurosurgery, 2017
Intervertebral disk (IVD) degeneration is a natural progression of the aging process. Degenerative disk disease (DDD) is a pathologic condition associated with IVD that has been associated with chronic back pain.
James E. Dowdell, M. Erwin, Theodoe Choma, A. Vaccaro, J. Iatridis, Samuel K. Cho   +5 more
semanticscholar   +1 more source

Clinical and magnetic resonance imaging characterization of cervical spondylomyelopathy in juvenile dogs

Journal of Veterinary Internal Medicine, 2019
Background Cervical spondylomyelopathy (CSM) occurs because of compression of the cervical spinal cord, nerve roots, or both, usually affecting young adult to older large and giant breed dogs. Juvenile dogs are affected infrequently.
Marília de AlbuquerqueBonelli, Ronaldo C. daCosta   +1 more
doaj   +1 more source

Luteoloside Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration

Frontiers in Pharmacology, 2019
Intervertebral disk degeneration (IDD) is the major cause of low back pain (LBP), which affects 80% of the world’s population. Interleukin 1 beta (IL-1β) is a major inflammatory factor that accelerates disk degeneration, and IL-1β levels increase in ...
Jialiang Lin, Jiaoxiang Chen, Zengjie Zhang, Tianzhen Xu, Zhenxuan Shao, Xiaobin Wang, Yuanzhe Ding, Naifeng Tian, Haiming Jin, Sunren Sheng, Weiyang Gao, Yan Lin, Xiaolei Zhang, Xiangyang Wang   +13 more
semanticscholar   +1 more source

LINC00969 promotes the degeneration of intervertebral disk by sponging miR‐335‐3p and regulating NLRP3 inflammasome activation

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2019
Long noncoding RNAs (LncRNAs) may serve as miRNA sponges to regulate the expressions of miRNA target genes. LncRNA LINC00969 has been indicated to be upregulated in intervertebral disk degeneration.
Lei Yu, Yingjie Hao, chaojun Xu, Guangduo Zhu, Yingchun Cai   +4 more
semanticscholar   +1 more source

FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration

Aging Cell, 2018
Intervertebral disk (IVD) degeneration is a prevalent age‐associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis during aging ...
O. Alvarez-Garcia, T. Matsuzaki, M. Olmer, Kohei Miyata, S. Mokuda, D. Sakai, K. Masuda, H. Asahara, M. Lotz   +8 more
semanticscholar   +1 more source

Obesity Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances via MAPK Pathway Activation in Intervertebral Disk Degeneration

Frontiers in Physiology, 2019
Obesity may promote intervertebral disc degeneration (IDD) by non-mechanical means, by influencing levels of free fatty acids which could impair cell metabolism.
Xuyang Zhang, Jian Chen, Bao Huang, Jiasheng Wang, Z. Shan, Jun-hui Liu, Yi-lei Chen, Shengyun Li, S. Fan, F. Zhao   +9 more
semanticscholar   +1 more source

Case report: Double adjacent ventral slot in two medium-sized breed dogs

Frontiers in Veterinary Science
Two medium-sized, 7-year-old dogs, with no previous history of pain, presented with acute neurologic symptoms consistent with intervertebral disk disease. Both cases had CT, where cervical pathology was identified.
Razvan Grigore Cojocaru, Bogdan Sicoe, Cristina Gaspar, Alexandra Grigoreanu, Gabriel Orghici, Ioan Tibru, Radu Lacatus   +6 more
doaj   +1 more source

Theoretical Explorations Generate New Hypotheses About the Role of the Cartilage Endplate in Early Intervertebral Disk Degeneration

Frontiers in Physiology, 2018
Altered cell nutrition in the intervertebral disk (IVD) is considered a main cause for disk degeneration (DD). The cartilage endplate (CEP) provides a major path for the diffusion of nutrients from the peripheral vasculature to the IVD nucleus pulposus ...
Carlos Ruiz Wills, Baptiste Foata, M. G. González Ballester, J. Karppinen, J. Noailly   +4 more
semanticscholar   +1 more source