Results 41 to 50 of about 425,188 (323)

Sericin/crocetin micro/nanoparticles for nucleus pulposus cells regeneration: An “active” drug delivery system

Frontiers in Pharmacology, 2023
Introduction: Initiation and progression of intervertebral disk degeneration are linked to oxidative stress, with reactive oxygen species being a key factor.
Elia Bari, Sara Perteghella, Giovanna Rassu, Elisabetta Gavini, Giacomo Luigi Petretto, Maria Cristina Bonferoni, Paolo Giunchedi, Maria Luisa Torre   +7 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

CT-Scan Based Evaluation of Dorsal-to-Ventral Ratios of Paraspinal Musculature in Chondrodystrophic and Non-chondrodystrophic Dogs

Frontiers in Veterinary Science, 2020
Objective: To assess and objectively quantify, with CT-scan exams, differences in cervical paraspinal musculature and vertebrae angulation that might influence the different predisposed sites for intervertebral disk disease observed in chondrodystrophic ...
Katinka Hartmann, Pia Düver, Stephan Kaiser, Carolin Fischer, Franck Forterre   +4 more
doaj   +1 more source

Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk

Cell Death and Disease, 2018
Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD ...
W. Guo, Bin Zhang, Kun Mu, S. Feng, Zhan-yin Dong, G. Ning, Hao-ran Li, Shen Liu, Ling Zhao, Yan Li, Bing-Bing Yu, Huiquan Duan, Chao Sun, Yong-Jin Li   +13 more
semanticscholar   +1 more source

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

Advanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen, Chan Xue, Feifei Ni, Binwu Hu, Miaoheng Yan, He Zhang, Yuxiang Hu, Xiaoyao Peng, Guangfang Li, Yu Han, Hongjian Liu, Zengwu Shao, Qin Wang, Yulong Wei   +13 more
wiley   +1 more source

Decellularization and characterization of a whole intervertebral disk xenograft scaffold.

Journal of Biomedical Materials Research. Part A, 2018
Intervertebral disk (IVD) degeneration is a multifactor process that results in the physical destruction of the nucleus pulposus (NP) and annulus fibrosus (AF).
A. Hensley, J. Rames, Victor Casler, C. Rood, Joshua D Walters, Christopher Fernandez, S. Gill, J. Mercuri   +7 more
semanticscholar   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Changes in Intervertebral Disk Mechanical Behavior During Early Degeneration.

Journal of Biomechanical Engineering, 2018
Intervertebral disk (IVD) degeneration is commonly described by loss of height and hydration. However, in the first stage of IVD degeneration, this loss has not yet occurred.
C. Paul, K. Emanuel, I. Kingma, A. J. van der Veen, R. Holewijn, Pieter-Paul A. Vergroesen, P. M. van de Ven, M. Mullender, M. Helder, T. Smit   +9 more
semanticscholar   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Atuveciclib Suppresses Intervertebral Disk Degeneration via the Inhibition of the NF-κB Signaling Pathway

Frontiers in Cell and Developmental Biology, 2020
Intervertebral disk degeneration (IVDD) is a spinal disk condition caused by an inflammatory response induced by various proinflammatory cytokines, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
Weiyu Ni, Weiyu Ni, Feizhou Zhang, Lin Zheng, Lin Zheng, Lili Wang, Yi Liang, Yi Liang, Yuhong Ding, Yuhong Ding, Jasper H. N. Yik, Dominik R. Haudenschild, Shunwu Fan, Shunwu Fan, Ziang Hu, Ziang Hu   +15 more
doaj   +1 more source