Results 41 to 50 of about 23,944 (304)
Advanced Science, EarlyView.Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo +17 more
wiley +1 more source
Advanced Science, EarlyView.ACE can modulate the CBL‐mediated K48 ubiquitination degradation of PSAP by altering its glycosylation levels in NP cells. As a result, NP cells secrete PSAP, which interacts with GPR37 on macrophage surfaces, facilitating their polarization toward the M2 phenotype. These M2 macrophages subsequently secrete TGFβ, which exerts feedback effects on the NP
Youfeng Guo +6 more
wiley +1 more source
Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts
Advanced Science, EarlyView.Cellular senescence contributes to disease burden in cardiovascular disease (CVD) and aging, highlighting the need to understand its induction. In primary cardiac fibroblasts, reduced strain and increased frequency, mimicking CVD, elicit a distinct senescent phenotype compared to oxidative stress.
Stephanie E. Schneider +5 more
wiley +1 more source
The conservative treatment of cervical hernia in dogs: the importance of respecting procedures – A case study [PDF]
Medicamentul Veterinar, 2019 The intervertebral disk herniation is an abnormal disposal of the nucleus pulposus and/or annulus fibrosus. The displacement can be found in the vertebral canal and/or intervertebral foramen.
Anca Bulai +2 more
doaj
Advanced Science, EarlyView.In this study, a bifunctional anti‐swelling hydrogel system is developed, which encapsulated anti‐senescence drugs quercetin, dasatinib, nucleus pulposus‐derived exosomes (NP‐Exo) to clear senescent nucleus pulposus cells, regulate the inflammatory disc microenvironment, and enhance nucleus pulposus cells activity, ultimately promoting the repair of ...
Songfeng Chen +14 more
wiley +1 more source
Advanced Science, EarlyView.A selenomethionine‐derived carbon dot (Se‐Met‐CD) serves as a potent nano‐antioxidant, efficiently scavenging reactive oxygen species, protecting nucleus pulposus cells from oxidative damage, restoring extracellular matrix homeostasis, and significantly mitigating intervertebral disc degeneration in vivo, which demonstrates great promise as a nanozyme ...
Qingzheng Zhang +4 more
wiley +1 more source
Coluna/Columna, 2011 OBJETIVO: Nosso estudo tem o objetivo de estudar as alterações histopatológicas, tais como neovascularização, infiltrado inflamatório, celularidade, apoptose, degeneração mucoide, alterações granulares e calcificação presentes nos tipos de hérnia ...
Luciano Miller Reis Rodrigues +5 more
doaj +1 more source
Morphology and function of pinniped necks: The long and short of it
The Anatomical Record, EarlyView.Abstract Terrestrial vertebrates from at least 30 distinct lineages in both extinct and extant clades have returned to aquatic environments. With these transitions came numerous morphological adaptations to accommodate life in water. Relatively little attention has been paid to the cervical region when tracking this transition.
Justin Keller +3 more
wiley +1 more source
Molecular Imaging Agents Specific for the Annulus Fibrosus of the Intervertebral Disk
Molecular Imaging, 2010 Low back pain is a prevalent medical condition that is difficult to diagnose and treat. Current imaging methods are unable to correlate pain reliably with spinal structures, and surgical removal of painful damaged or degenerating disks is technically ...
Summer L. Gibbs-Strauss +7 more
doaj +1 more source