Results 71 to 80 of about 425,188 (323)

Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair.

Journal of Biomechanical Engineering, 2016
There is currently a lack of clinically available solutions to restore functionality to the intervertebral disk (IVD) following herniation injury to the annulus fibrosus (AF).
R. Long, O. M. Torre, W. Hom, D. Assael, J. Iatridis   +4 more
semanticscholar   +1 more source

Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Senescent nucleus pulposus cells drive inflammatory M1 macrophage polarization, exacerbating intervertebral disc degeneration (IDD). Conversely, M1 macrophages accelerate NP cell senescence, creating a vicious cycle. iPSCs‐derived mesenchymal stem cell (iMSCs) exosomes break this loop by delivering miR‐100‐5p to suppress mTORC1/glycolysis in ...
Qian Xiang, Jiawen Zhan, Shuo Tian, Yongzhao Zhao, Zhenquan Wu, Jialiang Lin, Longting Chen, Longjie Wang, Shuai Jiang, Zhuoran Sun, Weishi Li   +10 more
wiley   +1 more source

Preliminary evaluation of the effects of photobiomodulation therapy and physical rehabilitation on early postoperative recovery of dogs undergoing hemilaminectomy for treatment of thoracolumbar intervertebral disk disease.

American Journal of Veterinary Research, 2017
OBJECTIVE To evaluate the effects of postoperative photobiomodulation therapy and physical rehabilitation on early recovery variables for dogs after hemilaminectomy for treatment of intervertebral disk disease. ANIMALS 32 nonambulatory client-owned dogs.
Michael Bennaim, Mathilde Porato, Astrid Jarleton, M. Hamon, James Carroll, K. Gommeren, M. Balligand   +6 more
semanticscholar   +1 more source

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

Advanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong, Hanwen Gu, Yuanqiang Zhang, Qunbo Meng, Qi Li, Kangle Song, Yanlin Li, Kaiwen Liu, Zhenchuan Liu, Rui Hu, Haoxi Zhai, Tian Li, Zemin Ling, Zhijian Wei, Fuxin Wei, Lei Cheng   +15 more
wiley   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Nature Communications, 2018
Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity.
Ming-liang Ji, Hua Jiang, Xue-jun Zhang, Pei-liang Shi, Chao Li, Hao Wu, Xiao-tao Wu, Yun-tao Wang, Chen Wang, Jun Lu   +9 more
doaj   +1 more source

Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation

Journal of Veterinary Internal Medicine, 2017
Background Ascending/descending myelomalacia (ADMM) is a severe complication of thoracolumbar intervertebral disk herniation (TL‐IVDH) in dogs. Hypothesis/Objectives To investigate the prevalence and risk factors for ADMM in nonambulatory dogs with ...
F. Balducci, S. Canal, Barbara Contiero, Marco Bernardini   +3 more
semanticscholar   +1 more source

FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1‐Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis

Advanced Science, EarlyView.
F‐box only protein 2 (FBXO2) combats intervertebral disc degeneration (IVDD) by coordinating dual protection. It activates PTEN‐induced putative kinase 1 (PINK1)‐Parkin mitophagy restoring mitochondrial function and targets lipocalin‐2 (LCN2) for degradation, suppressing ferroptosis.
Tongde Wu, Yanjin Wang, Beiduo Shen, Kai Guo, Ziqi Zhu, Yongzhou Liang, Jianhua Zeng, Desheng Wu   +7 more
wiley   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Clinical Practice Guidelines for Herniated Disk Treatment

Medisur, 2009
Clinical Practice Guidelines for Herniated Disk Treatment. The current concept is not only limited to the disorder caused by the rupture of the intervertebral disk, it also includes primary disk degeneration and the resulting spondylosis, and disk ...
José Ramón Tejera del Valle, Joaquín Aguilar Trujillo, Danny Barrueta Reyes, José Gómez Cruz, Líder Tejera Sánchez   +4 more
doaj   +2 more sources