Results 71 to 80 of about 23,944 (304)

Chronic sequelae and owner burdens are common following canine intervertebral disc disease

Veterinary Record, EarlyView.
Abstract Background Canine intervertebral disc disease (IVDD) is common and may be managed conservatively or surgically. However, little is known about long‐term sequelae, quality of life and owners’ emotional burden after diagnosis. Methods Information regarding signalment, neuroanatomical lesion localisation, diagnostic imaging results and treatment ...
Frederik Samsøe‐Schmidt, Mette Berendt, James Edward Miles   +2 more
wiley   +1 more source

Long‐term outcome of presumptive idiopathic hyperesthesia syndrome in a dog treated with fluoxetine

Veterinary Record Case Reports, EarlyView.
Abstract A 9‐year‐old, 10 kg, male, neutered, mixed‐breed dog was evaluated for a history of daily episodes of thoracic and lumbar hair horripilation with potential hypersensitivity and discomfort for at least 1 year, as reported by the owner. Dermatological disease was ruled out.
Claudia Pauciulo, Antonella Gallucci
wiley   +1 more source

Dual‐Lineage Chondrocyte‐Like Cells in the Nucleus Pulposus of Aging Intervertebral Discs Are Accelerated by Hedgehog Signaling Inactivation

Aging Cell, EarlyView.
During intervertebral disc degeneration, notochord‐derived nucleus pulposus cells progressively transdifferentiate into Krt19+ chondrocyte‐like cells (CLCs) and Krt19− CLCs, which are eventually replaced by Krt19− CLCs from non‐notochordal Gli1+ progenitors.
Lei Zhang, Chunmei Xiu, Hongji You, Jianquan Chen   +3 more
wiley   +1 more source

Treatment of Lumbar Intervertebral Disk Protrusion [PDF]

, 1952
Robert Henderson
openalex   +1 more source

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

Biological Reviews, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study

JOR Spine, 2018
Mechanical loading is inherently related to the function and degeneration of the intervertebral disc. We present a series of experiments aimed at measuring the effect of a loading/unloading cycle of the intervertebral disc on the mechanical properties of
Steven V. Beekmans, Kaj S. Emanuel, Theodoor H. Smit, Davide Iannuzzi   +3 more
doaj   +1 more source

Cone beam computed tomographic myelography in horses with cervical vertebral compressive myelopathy

Equine Veterinary Journal, EarlyView.
Abstract Background While computed tomographic (CT) myelography is increasingly available and has been evaluated in alive horses, objective criteria for diagnosing cervical vertebral compressive myelopathy (CVCM) are lacking. Objectives To establish morphometric dimensions of the cervical vertebral canal and spinal cords from horses with CVCM and ...
Sonia González‐Medina, Myra F. Barrett, Tawfik A. Aboellail, Bradley B. Nelson, Yvette S. Nout‐Lomas   +4 more
wiley   +1 more source

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells

The FEBS Journal, EarlyView.
P. acnes infection impairs the mitochondrial biogenesis of nucleus pulposus cells (NPCs) through the AMPK/SIRT‐1/PGC‐1α signaling pathway. This results in impaired mitochondria that are unable to generate sufficient ATP, and impaired delivery of mitochondrial reactive oxygen species to carry out the bactericidal process effectively.
Lemeng Ren, Changwei Li, Juntao Sun, Yuehuan Zheng, Yucheng Jiao, Jiancheng Zheng, Fangke Zhang, Yazhou Lin, Wenjian Wu, Peng Cao   +9 more
wiley   +1 more source

Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration

APL Materials
Intervertebral disk degeneration (IVDD) is a major cause of spinal pathology and pain and can lead to disability in adults in severe cases. The medication against disk degeneration is limited due to the lack of therapeutic drugs and ineffective delivery ...
Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tao Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao   +11 more
doaj   +1 more source

Polysaccharide Content of the Prolapsed Nucleus Pulposus of the Human Intervertebral Disk [PDF]

, 1961
F. Happey, A. Wiseman, A. Naylor
openalex   +1 more source