Results 71 to 80 of about 68,127 (346)

Danlu Tongdu tablets treat lumbar spinal stenosis through reducing reactive oxygen species and apoptosis by regulating CDK2/CDK4/CDKN1A expression [PDF]

open access: yesarXiv, 2023
Lumbar spinal stenosis (LSS) is caused by the compression of the nerve root or cauda equina nerve by stenosis of the lumbar spinal canal or intervertebral foramen, and is manifested as chronic low back and leg pain. Danlu Tongdu (DLTD) tablets can relieve chronic pain caused by LSS, but the molecular mechanism remains largely unknown.
arxiv  

Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration

open access: yesAdvanced Science, EarlyView.
A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou   +9 more
wiley   +1 more source

Análise comparativa histopatológica entre a hérnia de disco contida e extrusa Análisis comparativo histopatológico entre hernia discal contenida y extruida Comparative histopathologic analysis of contained and extruded disc herniation

open access: yesColuna/Columna, 2011
OBJETIVO: Nosso estudo tem o objetivo de estudar as alterações histopatológicas, tais como neovascularização, infiltrado inflamatório, celularidade, apoptose, degeneração mucoide, alterações granulares e calcificação presentes nos tipos de hérnia ...
Luciano Miller Reis Rodrigues   +5 more
doaj   +1 more source

Apoptosis in Displaced Temporomandibular Joint Disc with and without Reduction: An Immunohistochemical Study [PDF]

open access: yes, 2011
Internal derangement (ID) of the temporomandibular joint (TMJ) is due to an abnormal relationship of the articular disc to the mandibular condyle, glenoid fossa and articular eminence.
Almeida, Luis Eduardo   +3 more
core   +2 more sources

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

open access: yesAdvanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang   +13 more
wiley   +1 more source

The conservative treatment of cervical hernia in dogs: the importance of respecting procedures – A case study [PDF]

open access: yesMedicamentul Veterinar, 2019
The intervertebral disk herniation is an abnormal disposal of the nucleus pulposus and/or annulus fibrosus. The displacement can be found in the vertebral canal and/or intervertebral foramen.
Anca Bulai   +2 more
doaj  

Interacting Active Rectangles for Estimation of Intervertebral Disk Orientation [PDF]

open access: yes, 2006
This paper presents a fast and efficient method to determine intervertebral disk orientation in a magnetic resonance (MR) image of the spine. The algorithm originates from active contour theory and enforces a shape constraint to avoid leaks through weak ...
Abufadel, A.   +4 more
core   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

open access: yesAdvanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang   +11 more
wiley   +1 more source

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration-Correlation with histological grading in a rabbit disc degeneration model. [PDF]

open access: yes, 2019
Introduction:Estimation of intervertebral disc degeneration on magnetic resonance imaging (MRI) is challenging. Qualitative schemes used in clinical practice correlate poorly with pain and quantitative techniques have not entered widespread clinical use.
Chamoli, Uphar   +5 more
core   +1 more source

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