Regional mechanical matching dictates vertebral rotation improvement in severe rigid idiopathic scoliosis with halo-pelvic traction: a finite element analysis. [PDF]
Wang J +7 more
europepmc +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
Research progress of diffusion tensor imaging in lumbar degenerative diseases: a narrative review. [PDF]
Zhang N, Zhao Z, Tian J, Xu Y.
europepmc +1 more source
The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou +6 more
wiley +1 more source
A stratified analysis of multilevel direct decompression of degenerative lumbar central stenosis: Is fusion needed in the elderly? [PDF]
Ezeonu S +5 more
europepmc +1 more source
Abstract Microgravity is associated with stature increases, back pain and post‐flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright in 1 g upon changes in stature, anterior lumbar IVD height (via ultrasound), passive vertebral stiffness ...
David Marcos‐Lorenzo +6 more
wiley +1 more source
Transforaminal lumbar interbody fusion combined with fat decompression for grade III idiopathic spinal epidural lipomatosis: a case report. [PDF]
Yu X, Xing H, Chang Z.
europepmc +1 more source
A preliminary feasibility study of a tough hydrogel as a nucleus pulposus substitute for degenerative disc disease. [PDF]
Kang YM +7 more
europepmc +1 more source
Abstract Exposure to microgravity is associated with stature increases, moderate‐to‐severe back/neck pain and elevated lumbar and cervical intervertebral disc (IVD) herniation risk post‐flight. Whilst lumbar pathophysiology has been investigated, little attention has been placed on the cervical spine.
D. Marcos‐Lorenzo +5 more
wiley +1 more source
Causal effect of education on low back pain, intervertebral disc degeneration and sciatica: Mendelian randomization study. [PDF]
Wu Z +7 more
europepmc +1 more source

