Results 111 to 120 of about 709,562 (247)

Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang, Kristin L. Lenz, Emma Shen, Collin Murray, Nikitha Ada, Sarada Prasad, Mohammed Kuziez, Farshid Guilak, Arin K. Oestreich   +8 more
wiley   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Growth Plate Morphogens as Potential Modulators of Cellular Tissue Remodeling by Annulus Fibrosus Cells

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity of unknown etiology that begins in the intervertebral disc and emerges during pubertal growth. In the vertebral growth plate, adjacent to the disc, powerful growth plate morphogens (GPMs) modulate this growth. We evaluated whether GPMs can also alter the capacity of annulus
K. Stradovnik‐Poikilidis, M. Teunissen, F. M. Riemers, M. van Doeselaar, J. Foolen, F. Abinzano, M. A. Tryfonidou, S. J. P. Callens, K. Ito   +8 more
wiley   +1 more source

Are Ceramic Cages an Option for Lumbar Interbody Fusion? A Comparative Biomechanical Numerical Study

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The treatment of severe disc pathologies through lumbar interbody fusion (LIF) involves the insertion of an interbody cage into the degenerated disc space, together with a supporting fixation system. Conventional cage materials, such as Ti6Al4V and PEEK, present several limitations, most notably their non‐biodegradability ...
Davide Ninarello, Luigi La Barbera
wiley   +1 more source

Assessment of Vertebral Body Bone Quality in Adolescent Idiopathic Scoliosis (AIS) Using Micro‐CT, qBEI, and Nanoindentation—A Case Study

JOR SPINE, Volume 9, Issue 3, September 2026.
A new biopsy protocol enabled the first combined micro‐CT, qBEI, and nanoindentation study of AIS vertebral bodies, revealing slightly thicker trabeculae, broader mineralization distribution, and decreasing mineralization and reduced modulus with vertebral wedge angle severity—supporting a role for altered bone quality in AIS.
Natalia M. Castoldi, Edmund Pickering, Jiaqiu Wang, Madge Martin, James Roberts, Jurgis Ruza, Laure Stickel, Geoffrey N. Askin, Robert D. Labrom, Maree T. Izatt, Davide Fontanarosa, J. Paige Little, Peter Pivonka   +12 more
wiley   +1 more source

My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley   +1 more source

The Effect of Head‐Forward Posture on Lower Neck Loads and Dislocation Risk in Head‐First Impact: A Computational and Experimental Investigation

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background Subaxial cervical facet dislocation (CFD) is a severe neck injury associated with head‐first impact (HFI). However, CFD has not been reliably reproduced in experimental or numerical studies, limiting understanding of its underlying mechanics.
Mario Mongiardini, Duane Cronin, Ryan D. Quarrington   +2 more
wiley   +1 more source

Applications of Mesenchymal Stromal Cells for Treatment of Diseases

MedComm, Volume 7, Issue 9, September 2026.
This schematic summarizes the major therapeutic mechanisms of MSCs across different disease systems and highlights factors associated with MSCs dysfunction, together with current strategies to enhance MSCs function and therapeutic efficacy. This summary diagram illustrates that MSCs exert therapeutic effects in various diseases through multiple ...
Dongmei Xue, Yongsheng Li, Lei Wu
wiley   +1 more source

Artificial Intelligence in Veterinary Neurology: Comparative Insights From Human Medicine and Cross‐Species Technology Transfer

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Overview of major artificial intelligence applications in veterinary neurology, including neuroimaging, seizure prediction, gait and pain assessment, and prognostic modeling. The figure also highlights cross‐species technology transfer and key challenges, such as limited data, lack of standardization, and ethical concerns.
Kianoush Saberi, Rosull Saadoon Abbood, Sarah F. Al‐Taie, Aseel Smerat, Abdullaev Makhmudjon Mukhamedovich, Maksudova Malika Khamdamjonovna, Mohammad Hedayatinia, Arash Zarei, Mehrdad Nourizadeh, Amir Arsalan Ghahari, Mehrdad Neshat Gharamaleki, Fatemeh Malekinejad, Reza Akhavan‐Sigari   +12 more
wiley   +1 more source

Case Report: Long-term outcomes after surgery for spinal infiltrative lipoma in two dogs. [PDF]

Front Vet Sci
Van Stee LL, Van Rijn SJ, Bergmann W, Meij BP.   +3 more
europepmc   +1 more source