Results 101 to 110 of about 709,562 (247)

Association Between Conservative Treatment Modalities and Clinical Outcomes in Patients With Lumbosacral Disc Herniation Following Short Term and Long Term Treatments: A Retrospective Cohort Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Lumbar disc herniation (LDH), a leading cause of low back pain, necessitates effective conservative management to mitigate surgical interventions. This retrospective observational study evaluated the short‐term (6 months–2 years) and long‐term (3–6 years) efficacy of conservative therapies in 194 LDH patients from Iran ...
Bina Eftekharsadat, Shadi Khodaei, Raha Markazi‐Movaghar, Fatemeh ojaghlou, Azizeh Farshbaf‐Khalili, Soraya Babaie   +5 more
wiley   +1 more source

Juanbi Tang Attenuates Intervertebral Disc Degeneration by Suppressing p38MAPK/NF‐κB Signaling and Activating Atg5‐Dependent Autophagy to Promote Macrophage M2 Polarization: In Vivo and In Vitro Evidence

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
Graphical Abstract. Juanbi Tang (JBT) suppresses the p38MAPK/NF‐κB signaling pathway in disc‐infiltrating macrophages, simultaneously activating Atg5‐dependent autophagy. Autophagic degradation of p62/SQSTM1 consolidates NF‐κB inhibition through an autophagy–p62–NF‐κB regulatory module, facilitating macrophage M1‐to‐M2 polarization.
Ye‐Hui Wang, Wei Hou, Guo‐Sheng Tang, Xuan‐Geng Deng, Si‐Mao Song, Wei Cui, Yang Ye, Yang Yu   +7 more
wiley   +1 more source

Absceso Espinal Epidural secundario a bloqueo terapéutico: Presentación de un caso Epidural spinal abscess secondary to therapeutic blockade: Presentation of a case

Revista Médica Electrónica, 2010
The epidural spinal abscess is a purulent collection located between the dura mater and the rachimedular duct, being an unusual entity but a devastating situation, and causing a high morbimortality if it is not followed adequately.
Nereida Rosa Estorino Escaig, Eligio Vidal Jiménez, Crecencio Aneiro Alfonso   +2 more
doaj  

Lysosomal Dysfunction Is Associated With Intervertebral Disc Degeneration: Multiomics and Machine Learning Identify Molecular Subtypes and Hub Genes

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
Intervertebral disc degeneration (IVDD) is linked to lysosomal dysfunction, impaired autophagic degradation, and cellular senescence. Integrating bulk and single‐cell transcriptomics with machine learning, this study identified two lysosome‐related molecular subtypes and four hub genes: HYAL1, MMD, PLD3, and ANK3.
Yang Yang, Hong Li, Yixuan Ou, Yaping Yu, Kaiqiang Sun, Shixing Chen, Chenglong Ji   +6 more
wiley   +1 more source

Servikal faset çıkıklarında intervertebral disk yaralanmasının önemi

, 2012
Amaç: Servikal omurgada faset çıkıkları sık görülen, tanı ve tedavisinde güçlüklerle karşılaşılan, kuadripleji ve ölümle sonuçlanabilen ciddi yaralanmalardır.
Çopuroğlu, Cem, Yalnız, Erol, Özcan, Mert, Çiftdemir, Mert   +3 more
core   +1 more source

Cervical Radiculoneuropathy: Herniated Intervertebral Disk and Spondylosis

Cervical radiculopathy may be caused by a ruptured intervertebral disk, spondylosis, or a combination of these two processes. Soft disk material extrudes when the posterior annulus ruptures after the nucleus pulposus herniates.
Laws, Edward R., Heros, Roberto C., Sonntag, Volker K. H., Salcman, Michael   +3 more
core   +1 more source

Intervertebral disk stabilizers and implants [PDF]

, 2011
W artykule scharakteryzowano sposoby leczenia dysfunkcji i urazów kręgosłupa oraz przedstawiono różne elementy konstrukcyjne stosowane w chirurgii kręgosłupa.
Skalski, K., Skoworodko, J., Gierzyńska-Dolna, M.   +2 more
core  

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source

Large Language Models in Preclinical Spine Research: A Scoping Review and Expert Perspective on Evidence‐Aware Experimental Workflows

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background Preclinical spine research is limited by heterogeneous experimental reporting, fragmented documentation, and barriers to reproducibility and translational alignment. Large language models (LLMs) and related artificial intelligence (AI) technologies may support semantic interpretation, structured data extraction, and reasoning over ...
Siegmund Lang, Stefan Motov, Jonas Krueckel, Julian Scherer, Victor E. Staartjes, Karin Wuertz‐Kozak   +5 more
wiley   +1 more source