Results 51 to 60 of about 20,153 (223)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source

The finite element modeling and analysis of human lumbar segment herniation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective To study the biomechanical character of intervertebral disc in different loadings of axial compression, flexion, lateral bending, extension, rotation to develop the finite element (FE) of human lumbar L3-5 segment.
Ju⁃ying HUANG, Hai⁃yun LI, Feng⁃zeng JIAN, Hua⁃gang YAN   +3 more
doaj  

Changes in Biomechanical, Histological and Quantitative MRI Parameters in Lumbar Caprine Intervertebral Discs Subjected to Chondroïtinase-Induced Degeneration

Global Spine Journal, 2012
Introduction Intervertebral disk (IVD) degeneration is one of the major causes of low back pain. In the onset of IVD degeneration, the nucleus pulposus of the disk loses proteoglycans, decreasing the discs' capability to retain water.
C. P. Paul, G. J. Strijkers, M. de Graaf, A. Bisschop, T. H. Smit, M. N. Helder, B. J. van Royen, M. G. Mullender   +7 more
doaj   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Hirayama Disease and Traumatic Myelopathy: Capabilities and the Role of MRI in Forensic Medicine

Инновационная медицина Кубани
Objective: To determine key radiological features for differential diagnosis between traumatic myelopathy and Hirayama disease for the sake of forensic medical examination.Materials and methods: The study included 17 patients (age, 17-26 years) with ...
N. A. Medvedeva, N. S. Serova
doaj   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, EarlyView.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

Phenotypic characteristics of paroxysmal dyskinesia in 25 cats

Journal of Small Animal Practice, EarlyView.
Objectives Paroxysmal dyskinesia has, to date, been reported only systematically in Sphynx cats. This study aims to describe paroxysmal dyskinesia in additional breeds. Materials and Methods The medical records of cats from multiple hospitals presenting with episodes consistent with paroxysmal dyskinesia between 2020 and 2025 were retrospectively ...
T. Liatis, C. Maeso, A. De Stefani, A. Pergande, T. Elvira, A. Suñol   +5 more
wiley   +1 more source

Microendoscopic discectomy versus microscopic discectomy for treatment of lumbar disc herniations: a systematic review of randomized controlled trials

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective To compare the effectiveness and safety of microendoscopic discectomy (MED) versus microscopic discectomy (MD) for treatment of lumbar disc herniations.
Qing⁃guo LIU, Zhi⁃bin SONG, Jian⁃wei GAO, Xu⁃guang LI, Yun⁃li WU   +4 more
doaj  

Comparative Analysis of Three Vertebral Screw Placement Directions in Anterior Thoracolumbar Fracture Surgery: A Finite Element Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.
This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia, Yanjun Xie, Yi Yang, Yi Deng, Kerui Zhang, Changyong Shen, Ya Li, Litai Ma   +7 more
wiley   +1 more source