Results 61 to 70 of about 709,562 (247)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Changes in Biomechanical, Histological and Quantitative MRI Parameters in Lumbar Caprine Intervertebral Discs Subjected to Chondroïtinase-Induced Degeneration

Global Spine Journal, 2012
Introduction Intervertebral disk (IVD) degeneration is one of the major causes of low back pain. In the onset of IVD degeneration, the nucleus pulposus of the disk loses proteoglycans, decreasing the discs' capability to retain water.
C. P. Paul, G. J. Strijkers, M. de Graaf, A. Bisschop, T. H. Smit, M. N. Helder, B. J. van Royen, M. G. Mullender   +7 more
doaj   +1 more source

Predictive utility of computed tomography‐derived renal parenchymal volume for long‐term postoperative renal function in cats with hydronephrosis

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate the utility of preoperative feline renal parenchymal volume derived from computed tomography in predicting the serum creatinine concentration during the long‐term postoperative period. Materials and Methods In this retrospective clinical study, we included 13 client‐owned cats with normal kidneys and 24 cats with hydronephrosis ...
T. Nagumo, Y. Hoshino, S. Kobayashi, R. Fujiwara, M. Yamasaki, K. Nakata, M. Katayama   +6 more
wiley   +1 more source

The finite element modeling and analysis of human lumbar segment herniation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective To study the biomechanical character of intervertebral disc in different loadings of axial compression, flexion, lateral bending, extension, rotation to develop the finite element (FE) of human lumbar L3-5 segment.
Ju⁃ying HUANG, Hai⁃yun LI, Feng⁃zeng JIAN, Hua⁃gang YAN   +3 more
doaj  

Hirayama Disease and Traumatic Myelopathy: Capabilities and the Role of MRI in Forensic Medicine

Инновационная медицина Кубани
Objective: To determine key radiological features for differential diagnosis between traumatic myelopathy and Hirayama disease for the sake of forensic medical examination.Materials and methods: The study included 17 patients (age, 17-26 years) with ...
N. A. Medvedeva, N. S. Serova
doaj   +1 more source

Survival outcomes in dogs treated with vinorelbine‐based adjuvant treatment following surgical resection of grade II and III pulmonary carcinoma

Journal of Small Animal Practice, EarlyView.
Objectives Pulmonary carcinoma in dogs is commonly managed with surgical resection; however, the role of adjuvant chemotherapy for grade II and III carcinomas remains unclear. This retrospective multicentre study investigated the outcomes in dogs treated with vinorelbine‐based adjuvant treatment (as monotherapy or combined chemotherapy) following ...
N. Wong, L. Brockley, S. Rajan, J. Yu
wiley   +1 more source

Cervical Intervertebral Disk to Vertebral Body Ratios of Different Dog Breeds Based on Sagittal Magnetic Resonance Imaging. [PDF]

, 2018
To establish sagittal area and length reference values and ratios between apparently normal canine cervical vertebrae and intervertebral disks using magnetic resonance imaging.
Precht, Maria Christina, Fosgate, Geoffrey, Düver, Pia, Forterre, Franck, Hettlich, Bianca Felicitas   +4 more
core   +2 more sources

Comparative Analysis of Three Vertebral Screw Placement Directions in Anterior Thoracolumbar Fracture Surgery: A Finite Element Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.
This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia, Yanjun Xie, Yi Yang, Yi Deng, Kerui Zhang, Changyong Shen, Ya Li, Litai Ma   +7 more
wiley   +1 more source