Results 81 to 90 of about 3,856,202 (336)

A novel marker glycoprotein for the microvillus membrane of surface colonocytes of rat large intestine and its presence in small-intestinal crypt cells [PDF]

, 1988
Murine mAbs were produced against purified microvillus membranes of rat colonocytes in order to establish a marker protein for this membrane. The majority of antibodies binding to the colonic microvillus membrane recognized a single protein with a mean ...
B Stieger, Marxer, A., A Marxer, Fransen, J. A., Kedinger, M., J A Fransen, S U Gorr, M Kedinger, Gorr, S. U., Stieger, B., Hauri, H. P., H P Hauri   +11 more
core   +1 more source

Absorption and lymphatic transport of cholesterol and sitosterol in the rat

Journal of Lipid Research, 1969
An attempt was made to determine the mechanism for the greater absorbability of cholesterol as compared to sitosterol.Sitosterol-22,23-3H in different combinations with cholesterol-4-14C, dissolved in 0.8 ml of triolein, was fed to rats with lymph ...
Christer Sylvén, Bengt Borgström
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

"In silico" prediction of drug transport across physiological barriers [PDF]

, 2011
Physiological barriers maintain and safeguard homeostasis of certain body compartments by an increased resistance against free diffusion. Distribution and pharmacokinetics of drugs can be altered as well, if they have to cross these barriers in order to ...
Suenderhauf, Claudia
core   +1 more source

SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

eLife
The intestinal absorption of essential nutrients, especially those not readily biosynthesized, is a critical physiological process for maintaining homeostasis.
Yoshihisa Mimura, Tomoya Yasujima, Katsuhisa Inoue, Shogo Akino, Chitaka Namba, Hiroyuki Kusuhara, Yutaro Sekiguchi, Kinya Ohta, Takahiro Yamashiro, Hiroaki Yuasa   +9 more
doaj   +1 more source

The Metabolic Inhibition Model Which Predicts the Intestinal Absorbability and Metabolizability of Drug: Theory and Experiment

Biological Procedures Online, 1998
The intestinal absorption of analgesic peptides (leucine enkephalin and kyotorphin) and modified peptides in rat were studied. Although these peptides were not absorbed, the absorbability (absorption clearance) of these peptides were increased in the ...
Mizuma Takashi, Awazu Shoji
doaj   +1 more source

Human Primary Cell-Based Organotypic Microtissues for Modeling Small Intestinal Drug Absorption

Pharmaceutical Research, 2018
The study evaluates the use of new in vitro primary human cell-based organotypic small intestinal (SMI) microtissues for predicting intestinal drug absorption and drug-drug interaction.
S. Ayehunie, T. Landry, Zachary Stevens, A. Armento, P. Hayden, M. Klausner   +5 more
semanticscholar   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Increasing the viscosity of the intestinal contents stimulates proliferation of enterotoxigenic Escherichia coli and Brachyspira pilosicoli in weaner pigs [PDF]

, 2002
The present study was designed to evaluate the effect of increased viscosity of the intestinal digesta on proliferation of enterotoxigenic Escherichia coli and the intestinal spirochaete Brachyspira pilosicoli in weaned pigs.
Hampson, D.J., Hopwood, D.E., Pethick, D.W.   +2 more
core  

Dietary and pharmacological compounds altering intestinal calcium absorption in humans and animals [PDF]

, 2015
The intestine is the only gate for the entry of Ca to the body in humans and mammals. The entrance of Ca occurs via paracellular and intracellular pathways. All steps of the latter pathway are regulated by calcitriol and by other hormones.
Rivoira, María Angélica, Rodriguez, Valeria Andrea, Carpentieri, Agata Rita, Areco, Vanessa Andrea, Tolosa, Nori Graciela, Marchionatti, Ana María   +5 more
core   +1 more source