Results 81 to 90 of about 374,594 (305)

Effect of rejection on electrophysiologic function of canine intestinal grafts: Correlation with histopathology and na-k-ATPase activity [PDF]

, 1995
To investigate whether electrophysiologic changes can detect the early onset and progress of intestinal rejection, changes in in vitro electrophysiologic function, intestinal histopathology, and Na-K-ATPase activity were studied in dogs.
Billiar T R, Charney A N, Charney A N, Cohen W B, Dennison A R, Esmann M, Grant D, Kirkman R L, Lee M D, Lee T K, Madara J L, Meijssen M AC, Millard P R, Murase N, Murase N, Nakahara S, Nakamura K, Nordgren S, Quigley J P, Rosemurgy A S, Schamaun M, Schiller W R, Schmid T, Schroeder P, Stanford W P, Todo S, Todo S, Yoshimi F   +27 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Intestinal hephaestin potentiates iron absorption in weanling, adult, and pregnant mice under physiological conditions

Blood Advances, 2017
: Regulation of intestinal iron absorption is crucial to maintain body iron levels because humans have no regulated iron-excretory system. Elucidating molecular events that mediate intestinal iron transport is thus important for the development of ...
Caglar Doguer, Jung-Heun Ha, Sukru Gulec, Chris D. Vulpe, Gregory J. Anderson, James F. Collins   +5 more
doaj   +1 more source

Mathematical Modeling of Transport and Degradation of Feedstuffs in the Small Intestine [PDF]

, 2011
We describe a mathematical modeling of the digestion in the small intestine. The main interest of our work is to consider, at the same time, different aspects of the digestion i.e.
Bastianelli, Bueno, Christine Georgelin, Darcy, Guy Barles, Jean-René Licois, Karasov, Laplace, Lin, Logan, Logan, Masoomeh Taghipoor, McWilliams, Meunier, Miftahof, Philippe Lescoat, Piccinini, Rayner, Rivest, Roman, Srivastava, Wilfart, Zhao   +22 more
core   +4 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice*[S]

Journal of Lipid Research, 2009
FA transport protein 4 (FATP4), one member of a multigene family of FA transporters, was proposed as a major FA transporter in intestinal lipid absorption.
Jien Shim, Casey L. Moulson, Elizabeth P. Newberry, Meei-Hua Lin, Yan Xie, Susan M. Kennedy, Jeffrey H. Miner, Nicholas O. Davidson   +7 more
doaj   +1 more source

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]

, 2010
The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed.
Anna-Lena Ungell, Bauer, Britt-Marie Fihn, Constanze Hilgendorf, Englund, Harrison, Iain S. Haslam, Johan E. Karlsson, Lam, Nicholas L. Simmons, Noe, Read, Simon Lowes   +12 more
core   +2 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William, Dufès, Christine, Gaillard, Afsaneh, Gaillard, Frédéric, Muller, Jean-Marc, Olivier, Jean-Christophe   +5 more
core   +3 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source