Results 191 to 200 of about 196,268 (297)

<i>CTSB</i> mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury. [PDF]

Mol Med Rep
He S, Wang L, Wang Z, Yu S, Zhu Q, Xu Y, Jiang Y, Wu Y, Xiang H.   +8 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Lutonarin attenuates LPS-induced intestinal epithelial barrier dysfunction: a functional and transcriptomic analysis. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Du Q, Li J, Li G, Wang Z, Yu S, Wang L, Guo X, Wang D, Hui B, Tu Y, Sun W, Zhang X, Chen W.   +12 more
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Fungal determinants contributing to translocation of <i>Candida albicans</i> yeast cells through the intestinal epithelial barrier. [PDF]

Microlife
Sprague JL, Schille TB, Lange T, Sonnberger J, Allert S, Schönert J, Kasper L, Hube B.   +7 more
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

The non-synthetic sweeteners, miraculin and mogroside V, but not stevia, disrupt the intestinal epithelial barrier function through a sweet taste receptor-dependent mechanism. [PDF]

Sci Rep
Shil A, Amoakohene O, Chichger H.
europepmc   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Lack of intestinal Mucin-1 impairs intestinal epithelial barrier and promotes metabolic dysfunction-associated steatotic liver disease in male mice. [PDF]

Nat Commun
Li Z, Gu R, Liu D, Zhang Y, Qin Y, Li X, Qiao Y, Li Z, Guo J, Wang J, Meng H, Peng L.   +11 more
europepmc   +1 more source

Glucocorticoids revealed to augment intestinal epithelial barrier function [PDF]

Nature Reviews Gastroenterology & Hepatology, 2013
openaire   +2 more sources