Results 261 to 270 of about 124,874 (288)

Ethanol modulation of intestinal epithelial tight junction barrier

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1999
Previous studies have shown that high concentrations of ethanol (≥40%) cause functional damage of the gastrointestinal epithelial barrier by direct cytotoxic effect on the epithelial cells. The effects of lower noncytotoxic doses of ethanol on epithelial barrier function are unknown.
T Y, Ma, D, Nguyen, V, Bui, H, Nguyen, N, Hoa   +4 more
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How autophagy controls the intestinal epithelial barrier

Autophagy, 2021
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggregates, as well as the destruction of intracellular pathogens. Its role in the maintenance of the intestinal epithelium is of particular interest, as several autophagy-related genes have been associated with intestinal ...
Elisabeth G, Foerster, Tapas, Mukherjee, Liliane, Cabral-Fernandes, Juliana D B, Rocha, Stephen E, Girardin, Dana J, Philpott   +5 more
openaire   +2 more sources

Epithelial Barriers in Intestinal Inflammation

Antioxidants & Redox Signaling, 2011
The gastrointestinal epithelium transports solutes and water between lumen and blood and at the same time forms a barrier between these compartments. This highly selective and regulated barrier permits ions, water, and nutrients to be absorbed, but normally restricts the passage of harmful molecules, bacteria, viruses and other pathogens.
Lena J, John, Michael, Fromm, Jörg-Dieter, Schulzke   +2 more
openaire   +2 more sources

Regulation of the intestinal epithelial paracellular barrier

Pharmaceutical Science & Technology Today, 1999
Paracellular transport of orally-administered drugs, the passage of molecules between adjacent intestinal epithelial cells, is impeded by a range of structural and functional features found in the intestine. An increased knowledge of the mechanisms that govern the paracellular barrier will enable the pharmaceutical scientist to design novel and ...
, Daugherty, , Mrsny
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Ribosome Inactivation and the Integrity of the Intestinal Epithelial Barrier

Molecular Biology, 2018
The mistletoe lectin viscumin (MLI) is a ribosome-inactivating protein from Viscum album widely used in cancer therapy. Its antitumor properties are due to its immunomodulating action, previously demonstrated in experiments involving intravenous, subcutaneous, and oral administration of viscumin.
S V, Nikulin, N A, Mnafki Krainova, S A, Shilin, I N, Gazizov, D V, Maltseva   +4 more
openaire   +2 more sources

Probiotic bacteria and intestinal epithelial barrier function

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2010
The intestinal tract is a diverse microenvironment where more than 500 species of bacteria thrive. A single layer of epithelium is all that separates these commensal microorganisms and pathogens from the underlying immune cells, and thus epithelial barrier function is a key component in the arsenal of defense mechanisms required to prevent infection ...
Christina L, Ohland, Wallace K, Macnaughton   +1 more
openaire   +2 more sources

The intestinal epithelial barrier in the control of homeostasis and immunity

Trends in Immunology, 2011
In the intestine, multiple interactions occur with the external world. Thus, the intestinal mucosal barrier has to tolerate millions of microorganisms that commonly inhabit the gut, degrade and absorb food, and establish tolerance or immunity, depending on the nature of the encountered antigens.
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Effects of Dexmedetomidine on Intestinal Microcirculation and Intestinal Epithelial Barrier in Endotoxemic Rats

Anesthesiology, 2016
Abstract Background Dexmedetomidine reduces cytokine production in septic patients and reduces inflammation and mortality in experimental models of endotoxemia and sepsis. This study investigated whether dexmedetomidine attenuates endothelial dysfunction, intestinal microcirculatory dysfunction, and intestinal ...
Yu-Chang, Yeh, Chun-Yu, Wu, Ya-Jung, Cheng, Chih-Min, Liu, Jong-Kai, Hsiao, Wing-Sum, Chan, Zong-Gin, Wu, Linda Chia-Hui, Yu, Wei-Zen, Sun   +8 more
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The impact of ageing on the intestinal epithelial barrier and immune system

Cellular Immunology, 2014
The vast mucosal surface of the intestine is patrolled by a large number of lymphocytes forming the intestinal immune system. Like any other system in the body, this branch of the immune system is affected by ageing. Although our knowledge on the age-associated changes of the systemic immune system has improved over the past few years, our ...
Man, Angela L., Gicheva, Nadezhda, NICOLETTI, CLAUDIO   +2 more
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The Intestinal Epithelial Barrier: Does It Become Impaired with Age?

Digestive Diseases, 2009
The proportion of the population aged over 65 is increasing rapidly and malnutrition is a more common problem in elderly patients. The intestinal epithelium covers the surface of the digestive tract and consists of epithelial cells that constitute an efficient physical barrier between the dietary and enteric flora pathogens found in the intestinal ...
Johannes, Meier, Andreas, Sturm
openaire   +2 more sources