Results 221 to 230 of about 263,980 (286)

15-Lipoxygenase-dependent radiomitigation by NO^●-Donors suppresses ferroptosis in intestinal Epithelium: Multiomics MS imaging and LC-MS evidence. [PDF]

Redox Biol
Tyurina YY, Tian H, Dar HH, Akdogan M, Saritas E, Tyurin VA, Sparvero LJ, Kapralov AA, Shurin G, Fisher R, Epperly MW, Singh K, Bunimovich YL, Greenberger JS, Kagan VE, Bayir H.   +15 more
europepmc   +1 more source

The Life Span of the Intestinal Epithelium

Gastroenterology, 1949
openaire   +2 more sources

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Impact of UV Aging on the Toxicity and Bioavailability of Inductively Coupled Plasma Mass Spectrometry (ICP-MS)-Traceable Core-Shell Polystyrene Nanoplastics in an In Vitro Triculture Small Intestinal Epithelium Model. [PDF]

Toxics
Majumder S, Bazina L, DeLoid G, Garcia AG, Zuverza-Mena N, Konkol J, Tsilomelekis G, Verzi M, Zhu H, White JC, Demokritou P.   +10 more
europepmc   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Crosstalk Within the Intestinal Epithelium: Aspects of Intestinal Absorption, Homeostasis, and Immunity. [PDF]

Biomedicines
Yu LE, Yang WC, Liang YC.
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium. [PDF]

Commun Biol
Bruce JK, Li LY, Tang Y, Forster E, Winsor NJ, Bi PY, Krustev C, Keely S, Lee JE, Rohde JR, Gaisano HY, Philpott DJ, Girardin SE.   +12 more
europepmc   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source