Results 121 to 130 of about 3,701,616 (329)

The changing landscape of intestinal transplantation: Insights from the first quarter of the 21st century of Eurotransplant experience

Intestinal Failure
Background: Intestinal transplantation (ITx) remains one of the most complex procedures in solid organ transplantation. This study analyzes 25 years of Eurotransplant data to evaluate trends, outcomes, and prognostic factors.
Mando D. Filipe, Marit Kalisvaart, Manuel Maglione, Axel Jens, Stipislav Jadrijevic, Jan Willem Haveman, Andreas Pascher, Jacques Pirenne   +7 more
doaj   +1 more source

The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion [PDF]

, 2015
Background: Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS)
Aydin, B., Aydin, C., Berber, I., Birsen, O., Cevahir, N., Gumrukcu, G., Yenisey, C., Özban, Murat.   +7 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Healthcare cost of home parenteral nutrition and intestinal transplantation for paediatric chronic intestinal failure in Singapore

Intestinal Failure
Background: Chronic intestinal failure (IF) and long-term parenteral nutrition (PN) impose significant financial burden on patients and the healthcare system.
Fang Kuan Chiou, Ye Xin Koh, Lay Queen Ng, Lynette Goh, Yee Low, Yong Chen, Pui Ling Wai, Zhen Ling Ng, Debra Sudan, Prema Raj Jeyaraj   +9 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Case series of selenium insufficiency among infants with intestinal failure

Intestinal Failure
Background: Selenium (Se) is an essential trace element incorporated into ‘selenoenzymes’ that are necessary for immune, thyroid and antioxidant responses. Infants with intestinal failure (IF) require prolonged administration of parenteral nutrition (PN).
Darren Bodkin, Alisha Hemani, Jessica Miller, Jennifer Fraysur, Erica Fuchs   +4 more
doaj   +1 more source

Requirement of Zn to demonstrate HCO3-stimulated ATPase activity of rat small intestinal brush border. [PDF]

, 1979
The existence of a membrane-bound HCO3-stimulated ATPase in intestinal mucosa is controversial. A crude brush border fraction of rat small intestinal homogenates contained HCO3-ATPase activity which was inhibited by preincubation with 3 mM EDTA. Alkaline
Chou, LY, Humphreys, MH, Kaysen, GA
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

A rare case of non-oncologic metastasis: Keep calm and check the veins

Intestinal Failure
We report the case of a 57-year-old patient with short bowel syndrome and chronic intestinal failure secondary to multiple resections for Crohn’s disease, requiring parenteral nutrition (PN) since 1997.
Imane Habbal, Francisca Joly, Raphael Bacquet, Eric Le Bihan, Flore de Castelbajac   +4 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source