Results 141 to 150 of about 993,806 (361)

Application of SWATH Mass Spectrometry and Machine Learning in the Diagnosis of Inflammatory Bowel Disease Based on the Stool Proteome

Biomedicines
Inflammatory bowel disease (IBD) flare-ups exhibit symptoms that are similar to other diseases and conditions, making diagnosis and treatment complicated. Currently, the gold standard for diagnosing and monitoring IBD is colonoscopy and biopsy, which are
Elmira Shajari, David Gagné, Mandy Malick, Patricia Roy, Jean-François Noël, Hugo Gagnon, Marie A. Brunet, Maxime Delisle, François-Michel Boisvert, Jean-François Beaulieu   +9 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Cultivation of \u3cem\u3eTropheryma whipplei\u3c/em\u3e from Cerebrospinal Fluid [PDF]

, 2003
Whipple disease (WD) is a systemic disorder caused by the bacterium Tropheryma whipplei. Since the recognition of a bacterial etiology in 1961, many attempts have been made to cultivate this bacterium in vitro.
Fredricks, David N., Herbay, Axel von, Kosek, Jon C., Maiwald, Matthias, Ouverney, Cleber C., Relman, David A.   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Effects of dietary amylose/amylopectin ratio on antioxidant ability and amino metabolism in the liver of weaned piglets undergoing feed transition and challenged with lipopolysaccharide

Frontiers in Nutrition
To find out whether dietary amylose/ amylopectin ratio (DAR) could attenuate injury in lipopolysaccharide (LPS)-challenged piglets, sixty male weaned piglets (Duroc × Landrace × Yorkshire, 21 days old, 6.51 ± 0.64 kg) were allotted to 5 dietary ...
Can Yang, Can Yang, Xiaowu Tang, Min Wang, Han Yang, Huansheng Yang, Yancan Wang, Yulong Yin, Yulong Yin   +8 more
doaj   +1 more source

Investigating changes in intestinal health parameters of laying hens, broilers, and broiler breeder hens

, 2021
Maddison L. Wiersema
openalex   +2 more sources

Dietary Theabrownin Supplementation Improves Production Performance and Egg Quality by Promoting Intestinal Health and Antioxidant Capacity in Laying Hens [PDF]

, 2022
Tao Zhang, Shiping Bai, Xuemei Ding, Qiufeng Zeng, Keying Zhang, Li Lv, Jian Li, Huanwei Peng, Yue Xuan, Jianping Wang   +9 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effects of dietary digestible energy levels on growth performance, intestinal function, carcass traits, meat quality and blood biochemical parameters of Ningxiang pigs

Animal Nutrition
The purpose of this study was to explore the effects of changing the digestible energy (DE) level of the diet on the growth performance, intestinal function, carcass traits, meat quality and blood biochemical indices of Ningxiang pigs, and to ...
Zhaobin Wang, Chunchun Geng, Jiaqi Zhang, Xianglin Zeng, Xin Wang, Cheng Zhang, Weidong Zhang, Qiye Wang, Huansheng Yang, Yulong Yin   +9 more
doaj   +1 more source