Results 51 to 60 of about 319,352 (344)

mTOR signalling controls the formation of smooth muscle cell-derived luminal myofibroblasts during vasculitis

EMBO Reports
The accumulation of myofibroblasts within the intimal layer of inflamed blood vessels is a potentially catastrophic complication of vasculitis, which can lead to arterial stenosis and ischaemia.
Angus T Stock, Sarah Parsons, Jacinta A Hansen, Damian B D’Silva, Graham Starkey, Aly Fayed, Xin Yi Lim, Rohit D’Costa, Claire L Gordon, Ian P Wicks   +9 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Risk ranking of foodborne parasites : state of the art [PDF]

, 2017
A
Bouwknegt, Martijn, Devleesschauwer, Brecht, Dorny, Pierre, Gabriël, Sarah, Havelaar, Arie H, Quoilin, Sophie, Robertson, Lucy J, Speybroeck, Niko, Torgerson, Paul R, Trevisan, Chiara, van der Giessen, Joke WB   +10 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. [PDF]

, 2019
Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in ...
Arredondo, Juan, Cortopassi, Gino, Crakes, Katti R, Dandekar, Satya, Datta, Sandipan, Fenton, Anne, Gaulke, Christopher A, Giulivi, Cecilia, Grishina, Irina, Hirao, Lauren A, Marco, Maria L, Napoli, Eleonora, Sankaran-Walters, Sumathi, Santos Rocha, Clarissa   +13 more
core  

Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming [PDF]

, 2016
BACKGROUND: Although chronic morbidity in humans from soil transmitted helminth (STH) infections can be reduced by anthelmintic treatment, inconsistent diagnostic tools make it difficult to reliably measure the impact of deworming programs and often miss
A Ebrahim, A Jeandron, AC Clements, AJ Branscum, Alice V. Easton, B Levecke, B Nikolay, BA Boatin, Cassian Mwatele, Charles S. Mwandawiro, CR Stensvold, CV Holland, D Croce, D Engels, D Glinz, D Mupfasoni, DA Bundy, DA Bundy, DB Elkins, DJ Lunn, DM Deer, Elise M. O’Connell, FA Jonker, FL Santos, HL Guyatt, J Martin, JE Forrester, Jimmy H. Kihara, JJ Verweij, JJ Verweij, Joanne P. Webster, JP Webster, JS McCarthy, KE Hoagland, LM Assefa, LS Diamond, M Albonico, M Basuni, M Booth, M Taniuchi, Maurice R. Odiere, MO Harhay, N Katz, N Katz, NA Croll, P Hotez, PH Lamberton, R Anderson, R Bergquist, R Mejia, RD Pearson, Rita G. Oliveira, RJ Hove ten, RK Prichard, RL Pullan, RL Pullan, RM Anderson, RM Anderson, RO Cimino, Roy M. Anderson, S Brooker, S Brooker, S Knopp, S Knopp, S Knopp, S Lustigman, S Williams-Blangero, Sammy M. Njenga, SC Knowles, Simon J. Brooker, SJ Krauth, Stella Kepha, Thomas B. Nutman, TW Jia, WHO, XP Ye   +75 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Microbiota and hepatic diseases

Лечащий Врач, 2021
The data on the existing knowledge in the field of intestinal microbiota influence on human diseases were presented, in particular, non-alcoholic fat liver disease, alcoholic liver disease, inflammatory intestinal diseases and infectious gastrointestinal
T. E. Polunina
doaj  

Susceptibility to intestinal infection and diarrhoea in Zambian adults in relation to HIV status and CD4 count. [PDF]

, 2009
BACKGROUND: The HIV epidemic in sub-Saharan Africa has had a major impact on infectious disease, and there is currently great interest in the impact of HIV on intestinal barrier function.
Farthing, Michael J, Feldman, Roger A, Katubulushi, Max, Kelly, Paul, Mwansa, James, Sianongo, Sandie, Sinsungwe, Henry, Todd, Jim   +7 more
core   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source