Results 71 to 80 of about 2,641,131 (261)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Illness in Returned Travelers and Immigrants/Refugees: The 6-Year Experience of Two Australian Infectious Diseases Units. [PDF]

, 2008
BACKGROUND: Data comparing returned travelers and immigrants/refugees managed in a hospital setting is lacking. METHODS: We prospectively collected data on 1,106 patients with an illness likely acquired overseas who presented to two hospital-based ...
Brown, G V, O'Brien, D P, Torresi, J, Leder, K, Matchett, E   +4 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Susceptibility to intestinal infection and diarrhoea in Zambian adults in relation to HIV status and CD4 count. [PDF]

, 2009
BACKGROUND: The HIV epidemic in sub-Saharan Africa has had a major impact on infectious disease, and there is currently great interest in the impact of HIV on intestinal barrier function.
Feldman, RA, Roger A Feldman, Todd Jim, Mwansa, J, Henry Sinsungwe, H Sinsungwe (16116926), Feldman Roger A, Katubulushi, Max, Farthing Michael J, Paul Kelly, S Sianongo (16115693), Sianongo, Sandie, James Mwansa, Todd, Jim, Sianongo Sandie, Sinsungwe, H, M Katubulushi (16116548), Katubulushi, M, Sandie Sianongo, J Mwansa (16116545), Katubulushi Max, Farthing, MJ, P Kelly (9390197), R A Feldman (16116929), Sianongo, S, Michael J Farthing, Sinsungwe Henry, Sinsungwe, Henry, Kelly Paul, Mwansa James, M J Farthing (16115624), Farthing, Michael J, Feldman, Roger A, Mwansa, James, Kelly, Paul, Jim Todd, J Todd (9885689), Kelly, P, Todd, J, Max Katubulushi   +39 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Acute respiratory viral infection: challenges of diagnosis and treatment

Медицинский совет, 2013
One of the most important features of acute respiratory viral infection (ARVI) is the continuous increase in the prevalence and proportion of this disease in the structure of human pathology today.
E. V. Nosulya
doaj   +1 more source

Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities [PDF]

, 2012
Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary
Grobusch, Martin P., Pletschette, Michel, Mchugh, Timothy D., Schwank, Samana, Zumla, A, McNerney, R., Squire, S. Bertel, Ford, Nathan, Kim, P.S., Marais, B, Squire, S B, Migliori, Giovanni Batista, Bates, M, McHugh, Timothy D, Grobusch, M.P., McNerney, R, Migliori, G-B, Migliori, Giovanni-Batista, Squire, Bertie, Lawn, S, O'Grady, J, Chakaya, J., Lawn, Steve, Mwaba, Peter, Harari, Alexandre, Memish, Z, Harari, A., Cox, Helen, Abubakar, I, Ford, N, Hoelscher, Michael, Chakaya, J, Kim, Peter, Zijenah, L, Casenghi, M., Grobusch, M P, Casenghi, Martina, McHugh, T D, Marais, B., Weyer, K., Pantaleo, Giuseppe, Schito, Marco, Pletschette, M, Abubakar, Ibrahim, Atun, Rifat, Weyer, K, Mchugh, Timothy, O'Grady, J., Schwank, S, Mwaba, P., Grobusch, Martin P, Mwaba, P, Casenghi, M, Lawn, S., Squire, S, Zijenah, L., Ditui, Lucica, Cox, H., Pantaleo, G, Kim, P S, Schito, M, Weyer, Karin, O'Grady, Justin, Atun, R, Kim, Peter S, Harari, A, Grobusch, Martin, Abubakar, I., Zijenah, Lynn, Bates, Matthew, Memish, Ziad, Cox, H, Pletschette, M., Memish, Z., Schwank, S., Squire, S Bertel, Migliori, G.B., Ditui, L., McNerney, Ruth, Hoelscher, M., McHugh, T.D., Bates, M., Swaminathan, Soumya, Marais, Ben, Maeurer, Markus, Pantaleo, G., Zumla, A., Maeurer, M, Swaminathan, S, Kim, Peter S., Ditui, L, Hoelscher, M, Squire, S.B., Chakaya, Jeremiah, Ford, N., Zumla, Alimuddin, Schito, M., Maeurer, M., Swaminathan, S., Atun, R., Grobusch, MP, Mchugh, TD, Chakaya,, J et. al, Maeurer, M,   +103 more
core   +1 more source