Results 71 to 80 of about 317,603 (310)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Eubiosis and dysbiosis: the two sides of the microbiota [PDF]

, 2016
The microbial ecosystem of the gastrointestinal tract is characterized by a great number of microbial species living in balance by adopting mutualistic strategies. The eubiosis/dysbiosis condition of the gut microbiota strongly influences our healthy and
Cacciotti, Fatima, Cicerone, Clelia, Corazziari, Enrico Stefano, Gagliardi, Antonella, Iebba, Valerio, Mancini, Carlo, Pantanella, Fabrizio, Santangelo, Floriana, Schippa, Serena, Totino, Valentina, Trancassini, Maria   +10 more
core  

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions [PDF]

, 2017
Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries.
Begum, Yasmin Ara, Ciorba, Matthew A, Fleckenstein, James M, Hultgren, Scott J, Kuhlman, F. Matthew, Qadri, Firdausi, Rashu, Rasheduzzaman, Sheikh, Alaullah   +7 more
core   +3 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Acute respiratory viral infection: challenges of diagnosis and treatment

Медицинский совет, 2013
One of the most important features of acute respiratory viral infection (ARVI) is the continuous increase in the prevalence and proportion of this disease in the structure of human pathology today.
E. V. Nosulya
doaj   +1 more source

Mechanism of action of probiotics [PDF]

, 2013
The modern diet doesn't provide the required amount of beneficial bacteria. Maintenance of a proper microbial ecology in the host is the main criteria to be met for a healthy growth.
Balcazar JL, Caglar E, Connolly E, Cremonini F, De Keersmaecker SC, Delcenserie V, Eizaguirre I, Fioramonti Jean, Fonden R, Galdeano CM, Guarner F, Hallegraeff GA, Harish K, Haskard CA, Imase K, Irianto A, Isabel S. Carvalho, Kaila M, Kaila M, Katharina E, Link-Amster H, Lionetti E, Mangell P, Marteau P, Mattar AF, Michael de Vrese, Norin E, Oatley JT, R. Raja, R. Ravikumar, Raja R, Raja R, Raja R, Raja R, Reid G, S Hemaiswarya, Saggioro A, Salminen S, Sarah Lebeer, Silva M, Singh SD, Tubelius P, Venkat HK, Vrese M, Weber P, Wolf BW   +45 more
core   +4 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens. [PDF]

, 2009
Diarrhea in patients with acquired immune deficiency syndrome (AIDS) has proven to be both a diagnostic and treatment challenge since the discovery of the human immunodeficiency virus (HIV) virus more than 30 years ago.
Cello, John P, Day, Lukejohn W
core  

Allergic Disorders in Africa and Africans: Is it Primarily a Priority? [PDF]

, 2010
In Africa, the burden of some diseases has been a problem for centuries. The spectrum of African diseases includes allergies, infections, nutritional deficiencies, and natural disasters.
Adams, Araujo, Araujo, Asmah, Breman, Brugman, Butler, Carvalho, Chaisson, Cooper, Cooper, Cooper, Cullinan, Dagoye, Dagoye, Du Toit, Erasto Vitus Mbugi, Estmbale, Gadermaier, Grant, Jaffu Othniel Chilongola, Jeannin, Jeebhay, Jeebhay, Kamradt, Linneberg, Linneberg, Lopata, Lynch, Lynch, Madsen, Marshall, Matricardi, Matricardi, Mercer, Modjarrad, Moore, Motala, Ndiaye, Nicolaou, Nyan, Obeng, Obihara, Obihara, Obihara, Obihara, Obihara, Obihara, Okano, Pacifico, Palyvos, Pawankar, Platts-Mills, Potter, Potter, Potter, Potter, Rauter, Riedler, Scrivener, Sibanda, Sibanda, Steinman, Thyssen, Tohon, van den Biggelaar, van den Biggelaar, van den Biggelaar, van der Kleij, van Niekerk, Van Niekerk, Veien, Veien, Vergara, Weinberg, Westritschnig, Wuthrich, Yazdanbakhsh, Yazdanbakhsh, Yazdanbakhsh, Zar   +80 more
core   +1 more source