Results 61 to 70 of about 188,056 (260)

Infectious and Non-infectious Diseases of the Digestive System. Epidemiological Interrelation

Эпидемиология и вакцинопрофилактика, 2019
Background. Infectious and non-infectious diseases of the digestive system are common in Russia and worldwide and have major social and economic significance, yet the importance of infectious diseases in development of chronic digestive disorders is not ...
M. O. Antipov, A. Ya. Mindlina
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The volatile and heterogeneous gut microbiota shifts of COVID‐19 patients over the course of a probiotics‐assisted therapy

Clinical and Translational Medicine, 2021
Chunyan Wu, Qian Xu, Zhan Cao, Dengdeng Pan, Ying Zhu, Sheng Wang, Danping Liu, Zhigang Song, Wei Jiang, Yumeng Ruan, Yongkun Huang, Nan Qin, Hongzhou Lu, Huanlong Qin   +13 more
doaj   +1 more source

Association between lactate-to-albumin ratio and mortality in hepatic failure: a retrospective cohort study

BMC Infectious Diseases
Background Liver failure has a high mortality rate, and currently, there is no convenient risk predictor. The lactate-to-albumin ratio (LAR) has emerged as a promising predictor in various critical illnesses. However, its potential role in predicting all-
Huan Wu, Long Wu, Li Luo, Hai-yang Li, Bao-fang Zhang   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Epidemiological characteristics of mortality from infectious intestinal diseases (diarrhea) Paraguay (2015-2019)

Medicina Clínica y Social
Introduction: Infectious intestinal diseases (diarrhea) are a major cause of morbidity and mortality worldwide. In 2015, it constituted the ninth leading cause of death for all ages.
Eva Fabiana Merles Aranda, Juan Edgar Tullo Gómez, Derlis Duarte Zoilán, Elder Oliveira Da Silva, Myriam Elizabeth Rivas Kiese, Pasionaria Ramos   +5 more
doaj   +1 more source

Study on association factors of intestinal infectious diseases based-Bayesian spatio-temporal model. [PDF]

BMC Infect Dis, 2023
Zhan Y, Gu H, Li X.
europepmc   +1 more source