Results 1 to 10 of about 596,920 (286)

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay [PDF]

EMBO Molecular Medicine
CARD14 is an intracellular NF-κB signaling mediator in the skin, and rare CARD14 variants have been associated with psoriasis and atopic dermatitis. CARD14 is also expressed in intestinal epithelial cells (IEC).
Aigerim Aidarova, Marieke Carels, Mira Haegman, Yasmine Driege, Steven Timmermans, Eline Van Damme, Javier Aguilera-Lizarraga, Maria Francesca Viola, Rita de Cássia Collaço, Joan Manils, Steven C Ley, Frank Bosmans, Tom Van de Wiele, Guy Boeckxstaens, Claude Libert, Rudi Beyaert, Inna S Afonina   +16 more
doaj   +2 more sources

High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. [PDF]

, 2015
The development of intestinal permeability and the penetration of microbial products are key factors associated with the onset of metabolic disease. However, the mechanisms underlying this remain unclear. Here we show that, unlike liver or adipose tissue,
Armando, Aaron M, Costanzo, Anne, Gareau, Melanie G, Jameson, Julie M, Johnson, Andrew MF, Olefsky, Jerrold M, Quehenberger, Oswald   +6 more
core   +11 more sources

MFG-E8 Plays an Important Role in Attenuating Cerulein-Induced Acute Pancreatitis in Mice

Cells, 2021
Milk fat globule-EGF factor 8 (MFG-E8) is a secreted glycoprotein that regulates tissue homeostasis, possesses potent anti-inflammatory properties, and protects against tissue injury.
Heng-Fu Bu, Saravanan Subramanian, Hua Geng, Xiao Wang, Fangyi Liu, Pauline M. Chou, Chao Du, Isabelle G. De Plaen, Xiao-Di Tan   +8 more
doaj   +1 more source

SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells

Frontiers in Immunology, 2021
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 infection leads to lung injury remains elusive.
Hua Geng, Hua Geng, Saravanan Subramanian, Saravanan Subramanian, Longtao Wu, Heng-Fu Bu, Heng-Fu Bu, Xiao Wang, Xiao Wang, Chao Du, Chao Du, Isabelle G. De Plaen, Isabelle G. De Plaen, Xiao-Di Tan, Xiao-Di Tan, Xiao-Di Tan, Xiao-Di Tan   +16 more
doaj   +1 more source

Intestinal Barrier Dysfunction in the Absence of Systemic Inflammation Fails to Exacerbate Motor Dysfunction and Brain Pathology in a Mouse Model of Parkinson's Disease

Frontiers in Neurology, 2022
IntroductionParkinson's disease (PD) is the second most common neurodegenerative disease associated with aging. PD patients have systemic and neuroinflammation which is hypothesized to contribute to neurodegeneration.
Aeja Jackson, Phillip A. Engen, Christopher B. Forsyth, Christopher B. Forsyth, Christopher B. Forsyth, Maliha Shaikh, Ankur Naqib, Sherry Wilber, Dulce M. Frausto, Shohreh Raeisi, Stefan J. Green, Stefan J. Green, Brinda Desai Bradaric, Brinda Desai Bradaric, Amanda L. Persons, Amanda L. Persons, Robin M. Voigt, Robin M. Voigt, Robin M. Voigt, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian   +22 more
doaj   +1 more source

Gut epithelial barrier dysfunction in lupus triggers a differential humoral response against gut commensals

Frontiers in Immunology, 2023
IntroductionSystemic lupus erythematosus is an autoimmune disease with multisystemic involvement including intestinal inflammation. Lupus-associated intestinal inflammation may alter the mucosal barrier where millions of commensals have a dynamic and ...
María Botía-Sánchez, Georgina Galicia, Lorena Albaladejo-Marico, Daniel Toro-Domínguez, Maria Morell, Raquel Marcos-Fernández, Abelardo Margolles, Marta E. Alarcón-Riquelme, Marta E. Alarcón-Riquelme   +8 more
doaj   +1 more source

Intestinal epithelial cells necroptosis and its association with intestinal inflammation [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2019
This review focuses on the role of necroptosis, an alternative mode of cell death, in the pathogenesis of diseases associated with intestinal inflammation whose prevalence has been significantly increased for last decades, which substantiates the ...
Anton S. Tkachenko
doaj   +1 more source

Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer

Gut Microbes, 2022
Inflammatory bowel disease (IBD) is a chronic life-long inflammatory disease affecting almost 2 million Americans. Although new biologic therapies have been developed, the standard medical treatment fails to selectively control the dysregulated immune ...
Daniel F. Zegarra Ruiz, Dasom V. Kim, Kendra Norwood, Fatima B. Saldana-Morales, Myunghoo Kim, Charles Ng, Ryann Callaghan, Maisha Uddin, Lin-Chun Chang, Randy S. Longman, Gretchen E. Diehl   +10 more
doaj   +1 more source

Persistent systemic microbial translocation, inflammation, and intestinal damage during Clostridioides difficile infection [PDF]

, 2020
Background. Clostridioides difficile infection (CDI) might be complicated by the development of nosocomial bloodstream infection (n-BSI). Based on the hypothesis that alteration of the normal gut integrity is present during CDI, we evaluated markers of ...
Aversano, L., Battaglia, R., Bruno, G., Ciardi, M. R., Corazziari, E. S., de Angelis, M., Iera, J., Mascellino, M. T., Mastroianni, C. M., Miele, M. C., Morelli, S., Oliva, A., Venditti, M., Vullo, V.   +13 more
core   +1 more source

Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation

Cell & Bioscience, 2023
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that has significant immunotoxic effects.
Yue Chen, Yadong Wang, Yawei Fu, Yulong Yin, Kang Xu   +4 more
doaj   +1 more source