Results 61 to 70 of about 596,920 (286)

A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: Macrophage polarization

Frontiers in Pharmacology, 2022
Intestinal macrophages are the main participants of intestinal immune homeostasis and intestinal inflammation. Under different environmental stimuli, intestinal macrophages can be polarized into classical activated pro-inflammatory phenotype (M1) and ...
Zhihua Yang, Zhihua Yang, Shanshan Lin, Wanying Feng, Wanying Feng, Yangxi Liu, Zhihui Song, Zhihui Song, Guiyun Pan, Guiyun Pan, Yuhang Zhang, Yuhang Zhang, Xiangdong Dai, Xiangdong Dai, Xinya Ding, Lu Chen, Lu Chen, Yi Wang, Yi Wang   +18 more
doaj   +1 more source

Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease [PDF]

, 2007
Background/aim: Interleukin 31 (IL31), primarily expressed in activated lymphocytes, signals through a heterodimeric receptor complex consisting of the IL31 receptor alpha (IL31R\textgreeka) and the oncostatin M receptor (OSMR). The aim of this study was
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, Julia, Göke, Burkhard, Haller, Dirk, Seiderer, Julia   +6 more
core   +2 more sources

Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation [PDF]

Current Pathobiology Reports, 2015
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, contribute to significant morbidity and mortality globally. Despite an increase in incidence, IBD onset is still poorly understood. Mouse models of IBD recapitulate several aspects of human disease, but limited accessibility for live imaging and the lack of forward
Marjoram, Lindsay, Bagnat, Michel
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Intestinal parasites: Associations with intestinal and systemic inflammation [PDF]

Parasite Immunology, 2018
SummaryThe aim of the present study was to evaluate associations between intestinal parasitic infection with intestinal and systemic inflammatory markers in school‐aged children with high rates of obesity. Plasma concentrations of C‐Reactive Protein (CRP), leptin, TNF‐α, IL‐6 and IL‐10 were measured as systemic inflammation markers and count of stool ...
G. A. Zavala, O. P. García, M. Camacho, D. Ronquillo, M. Campos‐Ponce, C. Doak, K. Polman, J. L. Rosado   +7 more
openaire   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

IL-1β Induced Intestinal Inflammation Pathogenesis in East Friesian Sheep: Insights from Organoid Modeling

Animals
Establishing an appropriate model of intestinal inflammation in vitro is crucial for studying the pathogenesis of inflammatory bowel disease (IBD). While immortalized cell lines have long been employed to investigate intestinal cell functions and host ...
Yue Xue, Yulong Zhao, Shuo Yan, Ruilin Du, Huiming Zhang, Wenna Yao, Teligun Bao, Fei Pan, Siqin Bao, Xihe Li, Yongli Song   +10 more
doaj   +1 more source

The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus. [PDF]

PLoS ONE, 2014
Postoperative ileus is characterized by a transient impairment of the gastrointestinal motility after abdominal surgery. The intestinal inflammation, triggered by handling of the intestine, is the main factor responsible for the prolonged dysmotility of ...
Léa M M Costes, Jan van der Vliet, Giovanna Farro, Gianluca Matteoli, Sjoerd H W van Bree, Brenda J Olivier, Martijn A Nolte, Guy E Boeckxstaens, Cathy Cailotto   +8 more
doaj   +1 more source

Early markers of angiogenesis and ischemia during bowel conduit neovascularization [PDF]

, 2017
Background Bowel flaps are a good and reliable method to restore the continuity of the aerodigestive tract. Radiated fields, contaminated recipient sites, or depleted recipient vessels may increase the risk for ischemic injury after transfer.
Chen, Hung-chi, Chen, Pei-yu, Ciudad, Pedro, Li, Yun-fen, Lo Torto, Federico, Manrique, Oscar J., Nguyen, Doan-minh, Wong, Alex   +7 more
core   +1 more source