Results 81 to 90 of about 596,920 (286)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome. [PDF]

, 2012
Background/aimsCampylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens that cause PI-IBS. We
Alpern, Joel, Barlow, Gillian M, Chang, Christopher, Hwang, Laura, Jee, Sam-Ryong, Khoshini, Reza, Low, Kimberly, Marsh, Zachary, Morales, Walter, Pimentel, Mark, Pokkunuri, Venkata, Wang, Hanlin, Weitsman, Stacy   +12 more
core   +1 more source

Innate Lymphoid Cells in Intestinal Inflammation [PDF]

Frontiers in Immunology, 2017
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible for disease in genetically susceptible individuals.
Geremia, A, Arancibia-Cárcamo, C
openaire   +4 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Disrupted intestinal microbiota and intestinal inflammation in children with cystic fibrosis and its restoration with Lactobacillus GG: a randomised clinical trial.

PLoS ONE, 2014
Background & aimsIntestinal inflammation is a hallmark of cystic fibrosis (CF). Administration of probiotics can reduce intestinal inflammation and the incidence of pulmonary exacerbations.
Eugenia Bruzzese, Maria Luisa Callegari, Valeria Raia, Sara Viscovo, Riccardo Scotto, Susanna Ferrari, Lorenzo Morelli, Vittoria Buccigrossi, Andrea Lo Vecchio, Eliana Ruberto, Alfredo Guarino   +10 more
doaj   +1 more source

Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

Microbiome, 2022
Background Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the ...
Savannah J. Taylor, Maria G. Winter, Caroline C. Gillis, Laice Alves da Silva, Amanda L. Dobbins, Matthew K. Muramatsu, Angel G. Jimenez, Rachael B. Chanin, Luisella Spiga, Ernesto M. Llano, Vivian K. Rojas, Jiwoong Kim, Renato L. Santos, Wenhan Zhu, Sebastian E. Winter   +14 more
doaj   +1 more source

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip [PDF]

, 2015
The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens ...
A. J. M. Watson, B. J. Campbell, Beaulieu JF, Brown CC, C. A. Duckworth, Casellas F, D. M. Pritchard, Gelberg HB, J. M. Williams, Kaur P, Lee JS, Lobo SM, M. D. Burkitt, Mayhew TM, Moore R, Peschon JJ   +15 more
core   +4 more sources

Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis [PDF]

Frontiers in Oncology, 2014
Prom1/CD133 has been identified in colorectal, hepatocellular, and pancreatic cancer as a cancer stem cell marker and has been used as such to predict colon cancer recurrence in humans. Its potential molecular function as well as its role as a marker of intestinal regeneration is still not fully known.
Karim, Baktiar O, Rhee, Ki-Jong, Liu, Guosheng, Yun, Kyuson, Brant, Steven R   +4 more
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fasting-Induced Molting Impacts the Intestinal Health by Altering the Gut Microbiota

Animals
Fasting-induced molting (FIM) is a common method used to improve the laying performance of aged laying hens. Nevertheless, this approach may impose various stresses on chickens, such as disruptions in intestinal flora and inflammation issues within the ...
Hao Zhang, Yihui Zhang, Yujie Gong, Jun Zhang, Donghua Li, Yadong Tian, Ruili Han, Yujie Guo, Guirong Sun, Wenting Li, Yanhua Zhang, Xinlong Zhao, Xiaoran Zhang, Pengyu Wang, Xiangtao Kang, Ruirui Jiang   +15 more
doaj   +1 more source