Results 1 to 10 of about 24,054 (230)

Barrett’s Esophagus and Intestinal Metaplasia [PDF]

Frontiers in Oncology, 2021
Intestinal metaplasia refers to the replacement of the differentiated and mature normal mucosal epithelium outside the intestinal tract by the intestinal epithelium.
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lü   +7 more
doaj   +4 more sources

TFF3 initiates gastric intestinal metaplasia by activating JAK2 and STAT3 under high salt conditions [PDF]

Scientific Reports
The mechanism underlying the role of trefoil factor family 3 (TFF3) in intestinal metaplasia remains unclear. This study reveals the molecular mechanism by which TFF3, in the process of gastric mucosal epithelial cell intestinal metaplasia (IM) induced ...
Yanhong Wang, Feifei Qian, Baodong Shan, Li Zhang, Jie Zhong, Song Chen, Manman Yao, Shengnan Li, Xixiang Cao, Sujuan Fei, Xunlei Pang   +10 more
doaj   +2 more sources

Rabeprazole suppressed gastric intestinal metaplasia through activation of GPX4-mediated ferroptosis [PDF]

Frontiers in Pharmacology
BackgroundGastric intestinal metaplasia is a common pathological feature in patients with Helicobacter pylori (H. pylori) infection. Rabeprazole was widely used as the first-line regimen for H. pylori infectious treatment.
Jing Xie, Xinhua Liang, Fangfang Xie, Canxin Huang, Zijun Lin, Shuping Xie, Fangying Yang, Fengfeng Zheng, Lanlan Geng, Lanlan Geng, Wanfu Xu, Wanfu Xu, Sitang Gong, Sitang Gong, Li Xiang, Li Xiang   +15 more
doaj   +2 more sources

Pathogenesis and potential reversibility of intestinal metaplasia − a milestone in gastric carcinogenesis [PDF]

Radiology and Oncology
Non-cardia gastric cancer remains a major cause of cancer-related mortality worldwide, despite declining incidence rates in many industrialized countries.
Drnovsek Jan, Homan Matjaz, Zidar Nina, Smid Lojze M   +3 more
doaj   +2 more sources

Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer [PDF]

Heliyon
It has been revealed that certain organochlorine pesticides may increase the risk of gastric cancer incidence among farm workers. This research aimed to assay levels of 7 different organochlorine pesticides in the serum of functional dyspepsia ...
Gholamreza Asadikaram, Mohammad Reza Ashrafi, Sodaif Darvish Moghaddam, Moslem Abolhassani, Fatemeh Bagheri   +4 more
doaj   +2 more sources

CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells

iScience, 2022
Summary: Intestinal metaplasia is related to gastric carcinogenesis. Previous studies have suggested the important role of CDX2 in intestinal metaplasia, and several reports have shown that the overexpression of CDX2 in mouse gastric mucosa caused ...
Takahiro Koide, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi   +4 more
doaj   +1 more source

Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population

PLoS ONE, 2021
Background Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia.
Hudson M. Holmes, Andre G. Jove, Mimi C. Tan, Hashem B. El-Serag, Aaron P. Thrift   +4 more
doaj   +2 more sources

Analysis of Probable Risk Factors of Gastric Intestinal Metaplasia in Patients Referred to the Gastroenterology Clinic with Dyspepsia

Asian Pacific Journal of Cancer Biology, 2023
Background: Gastric intestinal metaplasia is known as a precursor of gastric cancer in the cascade of events from chronic gastritis to gastric adenocarcinoma.
Leila Mahmoudieh, Naghmeh Salarieh, Mojgan Forootan, Somayeh Fatemizadeh, Pardis Ketabi Moghadam   +4 more
doaj   +1 more source

Prevalence of subtypes of gastric intestinal metaplasia and its relationship with Helicobacter pylori infection

Journal of Pathology of Nepal, 2020
Background: Gastric intestinal metaplasia is seen chronic gastritis associated with Helicobacter pylori. The objective of this study was to determine the prevalence of subtypes of intestinal metaplasia and presence of Helicobacter pylori infection ...
Sanat Chalise, Roshan Ghimire, Sailesh B. Pradhan   +2 more
doaj   +1 more source

Shared features of metaplasia and the development of adenocarcinoma in the stomach and esophagus

Frontiers in Cell and Developmental Biology, 2023
Introduction: Plasticity is an inherent property of the normal gastrointestinal tract allowing for appropriate response to injury and healing. However, the aberrancy of adaptable responses is also beginning to be recognized as a driver during cancer ...
Yongji Zeng, Qing K. Li, Sujayita Roy, Jason C. Mills, Jason C. Mills, Ramon U. Jin   +5 more
doaj   +1 more source