Results 31 to 40 of about 21,088 (110)

Synergistic Interaction Between HPV‐16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Persistent infection with High‐Risk Human Papillomavirus (HR‐HPV), particularly HPV‐16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR‐HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia ...
Armando Chávez‐Ríos, Celina López‐Ruiz, Ian A. García‐Aguirre, Rodolfo Ocadiz‐Delgado, Francisco Garcia‐Sierra, Rogelio Hernández‐Pando, Solangy Lizcano‐Meneses, Patricio Gariglio   +7 more
wiley   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Inhibition of PHF1 promotes ferroptosis via IRES‐dependent Snail translation regulation in pancreatic ductal adenocarcinoma

VIEW, Volume 7, Issue 3, June 2026.
PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie, Shan Jin, Yao Zhan, Tiantian Du, Yaqi Dong, Peilong Li, Xiaoshi Zhang, Qiuchen Qi, Jie Gao, Chuanxin Wang   +9 more
wiley   +1 more source

How to Define the Gastroesophageal Junction

Digestive Endoscopy, Volume 38, Issue 6, June 2026.
ABSTRACT Adenocarcinomas at the gastroesophageal junction (GEJ) are increasingly common worldwide. Current classifications, such as Siewert type II and Nishi, provide a foundation, but establishing a transparent and widely accepted framework could considerably enhance identification and treatment efforts.
Ken‐ichi Mukaisho, Sachiko Kaida, Takahisa Nakayama, Masaji Tani, Michael Vieth, Takanori Hattori, Ryoji Kushima   +6 more
wiley   +1 more source

Changes in the 6th edition of the World Health Organization classification of tumours of the digestive system

Histopathology, Volume 88, Issue 7, Page 1295-1314, June 2026.
Changes and new entities in the 6th edition WCT of the digestive system, including structural, molecular, and diagnostic updates to standardize terminology and improve clinical relevance. Epithelial tumours are organized by site; neuroendocrine, mesenchymal and haematolymphoid tumours have dedicated chapters, with refined grading, redefined ...
Mark J Arends, Irene Esposito, Anthony J Gill, Ralph H Hruban, Joseph D Khoury, Motohiro Kojima, Elizabeth A Montgomery, Fatimah Abdulkareem, Fátima Carneiro, Guido Costamagna, Gregory Lauwers, Alexandros D Polydorides, Guido Rindi, Massimo Rugge, Peter Schirmacher, Amitabh Srivastava, James Yao, Jennelle C Hodge, James G Kench, Bharat Rekhi, Miguel Reyes‐Múgica, Antonia R Sepulveda, Chanjuan Shi, Pavitratha Puspanathan, Harshima Wijesinghe, Christine Giesen, Blanca Iciar Indave Ruiz, Dilani Lokuhetty, WCT standing editorial board, Iris D Nagtegaal, Wendy Cooper, Michael Eden, Andrew Field, Vicky Goh, Jennelle Hodge, James Kench, Joseph Khoury, Katia Leite, Zhiyong Liang, Daichi Maeda, George Netto, Bharat Rekhi, Miguel Reyes Múgica, Brian Rous, Ales Ryska, Shahin Sayed, Antonia R Sepulveda, Chanjuan Shi, Gary Tse   +48 more
wiley   +1 more source

Immune Landscape and Tumour Heterogeneity in Ovarian Cancer: Insights From Single‐Cell RNA Sequencing

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Tumour heterogeneity is a key factor in cancer progression, with immune responses within the tumour microenvironment (TME) contributing significantly to treatment resistance and immunotherapy outcomes. Recent advances in single‐cell RNA sequencing (scRNA‐seq) have provided unprecedented insights into the diverse immune cell populations ...
Sihan Chen, Ghada Moh. Samir Elhessewi, Helen Cai, Wedad M. Alawad, Manoj Kumar Mishra, Usamah Sayed   +5 more
wiley   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Standardized Image‐Based Arthroscopic Technique for Hip Synovial Chondromatosis: Long‐Term Patient Outcomes

Orthopaedic Surgery, Volume 18, Issue 6, Page 1223-1232, June 2026.
A clock‐face‐guided, imaging‐based arthroscopic protocol improves surgical orientation and facilitates complete removal of loose bodies in hip synovial chondromatosis, leading to favorable long‐term outcomes. ABSTRACT Objective Arthroscopic surgery is recommended for the treatment of hip synovial chondromatosis, as it allows patients to resume daily ...
Jinxi An, Jianing Yu, Rongzhen Lin, Mingyue Fan, Ziheng Bu, Wei Zhu, Jiachang Hong, Wei Liu, Junchao Huang, Yongjun Hu, Peng Wu   +10 more
wiley   +1 more source

Immune system benefits of pulmonary rehabilitation in chronic obstructive pulmonary disease

Experimental Physiology, Volume 111, Issue 6, Page 2787-2804, 1 June 2026.
Abstract Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by pulmonary and systemic inflammation. Inflammatory mediators show relationships with shortness of breath, exercise intolerance and health related quality of life. Pulmonary rehabilitation (PR), a comprehensive education and exercise training programme, is the
Asghar Abbasi, David Wang, William W. Stringer, Richard Casaburi, Harry B. Rossiter   +4 more
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source