Results 11 to 20 of about 741,485 (265)

Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression

bioRxiv, 2023
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. We analyzed 1256 gastric samples (1152 IMs) from 692 subjects through a prospective 10-year study.
K. Huang, Haoran Ma, Tomoyuki Uchihara, T. Sheng, R. Chong, F. Zhu, S. Srivastava, S. Tay, R. Sundar, A. Tan, Xuewen Ong, M. Lee, S. Ho, Tom Lesluyes, P. van Loo, J. Chua, Kalpana Ramnarayanan, T. Ang, Christopher Khor, J. Lee, S. K. Tsao, M. Teh, Hyun-Chae Chung, J. So, K. Yeoh, P. Tan, Singapore Gastric Cancer Consortium   +26 more
semanticscholar   +1 more source

Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia

Cancer Discovery, 2023
Barrett's esophagus and gastric intestinal metaplasia are molecularly similar precancerous lesions, with epithelial cells being mosaics of gastric and intestinal phenotypes and stromal cells showing features of cancer-associated fibroblasts.
K. Nowicki-Osuch, Lizhe Zhuang, T. S. Cheung, Emily L Black, N. Masqué-Soler, G. Devonshire, A. Redmond, Adam Freeman, Massimilliano di Pietro, N. Pilonis, W. Januszewicz, M. O'Donovan, S. Tavaré, J. Shields, R. Fitzgerald   +14 more
semanticscholar   +1 more source

Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)

Gut, 2021
Objective To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate

semanticscholar   +1 more source

Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal Metaplasia

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims Metaplasia in the stomach is highly associated with development of intestinal-type gastric cancer. Two types of metaplasias, spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal metaplasia (IM), are considered ...
Su-Hyung Lee, B. Jang, Jimin Min, Ela W. Contreras-Panta, Kimberly S. Presentation, A. Delgado, M. Piazuelo, Eunyoung Choi, J. Goldenring   +8 more
semanticscholar   +1 more source

Analysis of Probable Risk Factors of Gastric Intestinal Metaplasia in Patients Referred to the Gastroenterology Clinic with Dyspepsia

Asian Pacific Journal of Cancer Biology, 2023
Background: Gastric intestinal metaplasia is known as a precursor of gastric cancer in the cascade of events from chronic gastritis to gastric adenocarcinoma.
Leila Mahmoudieh, Naghmeh Salarieh, Mojgan Forootan, Somayeh Fatemizadeh, Pardis Ketabi Moghadam   +4 more
doaj   +1 more source

Prevalence of subtypes of gastric intestinal metaplasia and its relationship with Helicobacter pylori infection

Journal of Pathology of Nepal, 2020
Background: Gastric intestinal metaplasia is seen chronic gastritis associated with Helicobacter pylori. The objective of this study was to determine the prevalence of subtypes of intestinal metaplasia and presence of Helicobacter pylori infection ...
Sanat Chalise, Roshan Ghimire, Sailesh B. Pradhan   +2 more
doaj   +1 more source

Molecular Alterations in Gastric Intestinal Metaplasia [PDF]

International Journal of Molecular Sciences, 2021
Gastric cancer (GC) remains one of the most common causes of mortality worldwide. Intestinal metaplasia (IM) is one of the preneoplastic gastric lesions and is considered an essential predisposing factor in GC development. Here we present a review of recent most relevant papers to summarize major findings on the molecular alterations in gastric IM. The
Paulius Jonaitis, Limas Kupcinskas, Juozas Kupcinskas   +2 more
openaire   +2 more sources

Shared features of metaplasia and the development of adenocarcinoma in the stomach and esophagus

Frontiers in Cell and Developmental Biology, 2023
Introduction: Plasticity is an inherent property of the normal gastrointestinal tract allowing for appropriate response to injury and healing. However, the aberrancy of adaptable responses is also beginning to be recognized as a driver during cancer ...
Yongji Zeng, Qing K. Li, Sujayita Roy, Jason C. Mills, Jason C. Mills, Ramon U. Jin   +5 more
doaj   +1 more source

Gastric intestinal metaplasia [PDF]

Journal of Clinical Pathology, 2004
We read with interest the article by Dinis-Ribeiro et al concerning a follow up model for patients with atrophic gastritis and intestinal metaplasia (IM).1 The model proposed is based on “a minimum of two endoscopic biopsies”, although 40% of patients had at least three biopsies, and more than 15% of patients had more than four biopsies performed ...
C A Rubio, R Befrits
openaire   +1 more source

Is gastric intestinal metaplasia a risk factor for colorectal neoplasms?

Biotechnology & Biotechnological Equipment, 2021
Colorectal cancers are one of the most common types of cancer. Gastric intestinal metaplasia is considered a precancerous lesion that can progress into gastric cancer.
Remzi Beştaş, Nazım Ekin
doaj   +1 more source