Results 81 to 90 of about 358,126 (313)

Biotransformation of xenobiotics in human intestinal mucosa [PDF]

Environmental Health Perspectives, 1979
Drug-metabolizing enzymes, especially monooxygenases, play a major role in biotransformation and detoxification of many foreign compounds including environmental carcinogens. Although largely localized in the liver they are also found in the small intestine, which is the portal of entry of dietary toxins.
H P, Hoensch, R, Hutt, F, Hartmann
openaire   +2 more sources

The molecular landscape of colitis-associated carcinogenesis [PDF]

, 2016
In spite of the well-established histopathological phenotyping of IBD-associated preneoplastic and neoplastic lesions, their molecular landscape remains to be fully elucidated. Several studies have pinpointed the initiating role of longstanding/relapsing
D'Inca', Renata, Fassan, Matteo, Mescoli, Claudia, Michielan, Andrea, Rugge, Massimo, Saraggi, Deborah, Scarpa, Marco, Valeri, Nicola   +7 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium

JCI Insight
Circular RNAs (circRNAs) are highly expressed in the mammalian intestinal epithelium, but their functions remain largely unknown. Here, we identified the circRNA Cdr1as as a repressor of intestinal epithelial regeneration and defense.
Hee Kyoung Chung, Lan Xiao, Naomi Han, Jason Chen, Vivian Yao, Cassandra M. Cairns, Benjamin Raufman, Jaladanki N. Rao, Douglas J. Turner, Rosemary Kozar, Myriam Gorospe, Jian-Ying Wang   +11 more
doaj   +1 more source

Impact of arabinoxylan-enriched diets on the intestinal chemical barrier and microbiota composition in rainbow trout (Oncorhynchus mykiss)

Frontiers in Veterinary Science
IntroductionThis study was conducted to evaluate the effects of dietary AX inclusion on the chemical barrier, antioxidant function and intestinal microbiome of rainbow trout.MethodsFive isoproteic and isolipidic experimental diets were formulated to ...
Xindang Zhang, Xindang Zhang, Hengzhi Wang, Beibei Lin, Xiaolin Meng, Junming Deng, Junming Deng   +6 more
doaj   +1 more source

Th17, intestinal microbiota and the abnormal immune response in the pathogenesis of celiac disease [PDF]

, 2015
Celiac disease (CD) is an autoimmune enteropathy induced by the ingestion of gluten in genetically predisposed individuals who carry the HLA-DQ2 or -DQ8 alleles.
Cicerone, Clelia, Nenna, Raffaella, Pontone, Stefano   +2 more
core  

Treatment of helicobacter pylori infection in atrophic gastritis [PDF]

, 2018
Helicobacter pylori (Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection.
Annibale, B, Carabotti, M, Lahner, E
core   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

Journal of Animal Science and Biotechnology
Background As Holstein calves are susceptible to gastrointestinal disorders during the first week of life, understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal health.
Koki Nishihara, Clothilde Villot, Lautaro Cangiano, Le Luo Guan, Michael Steele   +4 more
doaj   +1 more source

Absorption of thiamine and nicotinic acid in the rat intestine during fasting and immobilization stress [PDF]

By perfusion of isolated sections of intestine with a solution containing thiamine at a concentration of 3.1 micromole, it was established that thiamine absorption in animals fasted for 72 hours decreased by 28 percent, whereas absorption increased by 12
Khmelevskiy, Y. V., Kirilyuk, O. G.
core   +1 more source