Results 51 to 60 of about 1,153,559 (335)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study

Journal of Neurogastroenterology and Motility, 2017
Background/Aims Chronic intestinal pseudo-obstruction (CIPO) is a serious, life-threatening motility disorder that is often related to bacterial overgrowth.
L. Gu, Chao Ding, H. Tian, Bo Yang, Xuelei Zhang, Yue Hua, Yifan Zhu, J. Gong, Weiming Zhu, Jie‐shou Li, Ning Li   +10 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Oclusão intestinal por compressas cirúrgicas intraluminais: experiência de cinco casos

Revista do Colégio Brasileiro de Cirurgiões
Despite being unusual, retained foreign bodies after surgical procedures is a matter of great concern for surgeons. The main purpose of this article is to describe five cases of intestinal obstruction due to intraluminal surgical sponges.
Christiano Marlo Paggi Claus, Cesar Giovani Conte, Júlio Cezar Uili Coelho, Renato Valmassoni Pinho   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Intestinal obstruction due to phytobezoars: An update.

World Journal of Clinical Cases, 2015
The term bezoar refers to an intraluminal mass in the gastrointestinal system caused by the accumulation of indigestible ingested materials, such as vegetables, fruits, and hair.
E. Dikicier, F. Altıntoprak, O. Ozkan, Orhan Yağmurkaya, M. Uzunoğlu   +4 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Desmoid tumour: a rare etiology of intestinal obstruction

The Pan African Medical Journal, 2015
Intestinal obstruction is a frequently encountered entity in surgical practice. The signs and symptoms, many a times, are suggestive of the level of obstruction, making the diagnosis of obstruction evident.
Gaurav Aggarwal, Sumit Shukla, Ankur Maheshwari, Rajkumar Mathur   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Etiological Spectrum of Dynamic Intestinal Obstruction

Gomal Journal of Medical Sciences, 2004
Background: Intestinal obstruction is a common and potentially dangerous surgical emergency with high morbidity and mortality if managed inappropriately. It is essential to distinguish between its various types. The aim of this study was to determine the
Tariq Wahab Khanzada, Abdul Samad, Champa Sushel   +2 more
doaj