A 3D co-culture intestinal organoid system for exploring glucose metabolism [PDF]
Current Research in Food Science, 2023 Many treatments have been used for glucose metabolism diseases such as type 2 diabetes, and all of those treatments have several advantages as well as limitations.
Jianping Nie +8 more
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Wnt/β-Catenin Pathway Activation Confers Fumonisin B1 Tolerance in Chicken Intestinal Organoid Monolayers by Enhancing Intestinal Stem Cell Function [PDF]
AnimalsFumonisin B1 (FB1) is a prevalent mycotoxin in moldy grains and feeds, highly toxic to livestock and compromising product quality while threatening food safety.
Shuai Zhang +7 more
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Construction of a Duck Intestinal Organoid Culture System: From Crypt Isolation to Medium Optimization [PDF]
AnimalsIntestinal organoids possess self-organizing capacity and recapitulate essential features of intestinal architecture and function, making them powerful models for investigating development, disease mechanisms, pharmacological testing, and host–microbe ...
Rui Tang +7 more
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The differentiation state of small intestinal organoid models influences prediction of drug-induced toxicity [PDF]
Frontiers in Cell and Developmental BiologyDrug-induced intestinal toxicity (GIT) is a frequent dose-limiting adverse event that can impact patient compliance and treatment outcomes. In vivo, there are proliferative and differentiated cell types critical to maintaining intestinal homeostasis ...
Jessica A. Klein +5 more
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Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection. [PDF]
PLoS Biology, 2022 Gastrointestinal effects associated with Coronavirus Disease 2019 (COVID-19) are highly variable for reasons that are not understood. In this study, we used intestinal organoid-derived cultures differentiated from primary human specimens as a model to ...
Kyung Ku Jang +8 more
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Microfluidic intestinal organoid-on-a-chip uncovers therapeutic targets by recapitulating oxygen dynamics of intestinal IR injury [PDF]
Bioactive Materials, 2023 Increasing evidence demonstrates that mammals have different reactions to hypoxia with varied oxygen dynamic patterns. It takes ∼24 h for tri-gas incubator to achieve steady cell hypoxia, which fails to recapitulate ultrafast oxygen dynamics of ...
Jinjian Huang +14 more
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Intestinal organoid models as tools to interrogate the physiology of human mucosal tissues and host-microbe interactions [PDF]
mSphereThe intestinal epithelium serves as a critical interface between the external environment and internal tissues, coordinating nutrient absorption, immune defense, and barrier integrity.
J. M. Lemme-Dumit
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A tunable human intestinal organoid system achieves controlled balance between self-renewal and differentiation [PDF]
Nature CommunicationsA balance between stem cell self-renewal and differentiation is required to maintain concurrent proliferation and cellular diversification in organoids; however, this has proven difficult in homogeneous cultures devoid of in vivo spatial niche gradients ...
Li Yang +7 more
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Animal Nutrition, 2022 Methionine and its hydroxy analogue (MHA) have been shown to benefit mouse intestinal regeneration. The intestinal organoid is a good model that directly reflects the impact of certain nutrients or chemicals on intestinal development.
Youli Wang +9 more
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Cell Regeneration, 2022 Intestinal organoids, derived from intestinal stem cell self-organization, recapitulate the tissue structures and behaviors of the intestinal epithelium, which hold great potential for the study of developmental biology, disease modeling, and ...
Fanlu Meng +13 more
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