Results 11 to 20 of about 21,783 (297)
Human Intestinal Organoids: Promise and Challenge
Frontiers in Cell and Developmental Biology, 2022 The study of human intestinal biology in healthy and diseased conditions has always been challenging. Primary obstacles have included limited tissue accessibility, inadequate in vitro maintenance and ethical constrains.
Jasin Taelman +5 more
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Current applications of intestinal organoids: a review
Stem Cell Research & TherapyIn the past decade, intestinal organoid technology has paved the way for reproducing tissue or organ morphogenesis during intestinal physiological processes in vitro and studying the pathogenesis of various intestinal diseases.
Tao Xiang, Jie Wang, Hui Li
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Intestinal organoid cocultures with microbes [PDF]
Nature Protocols, 2021 Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables the study of host-microbe interactions with great experimental control. This protocol comprises methods to coculture organoids with microbes, particularly focusing on human small intestinal and colon organoids exposed to individual bacterial species.
Jens Puschhof +10 more
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Advancing Intestinal Organoid Technology Toward Regenerative Medicine
Cellular and Molecular Gastroenterology and Hepatology, 2018 With the emergence of technologies to culture intestinal epithelial cells in vitro as various forms of intestinal organoids, there is growing interest in using such cultured intestinal cells as a source for tissue engineering and regenerative medicine ...
Tetsuya Nakamura, Toshiro Sato
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Intestinal organoids in farm animals [PDF]
Veterinary Research, 2021 AbstractIn livestock species, the monolayer of epithelial cells covering the digestive mucosa plays an essential role for nutrition and gut barrier function. However, research on farm animal intestinal epithelium has been hampered by the lack of appropriate in vitro models.
Beaumont, Martin +6 more
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Standard: Human intestinal organoids
Cell Regeneration, 2023 AbstractOrganoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications.
Yalong Wang +25 more
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Journal of Pediatric Gastroenterology and Nutrition, 2017 The development of sustainable intestinal organoid cell culture has emerged as a new modality for the study of intestinal function and cellular processes. Organoid culture is providing a new testbed for therapeutic research and development. Intestinal organoids, self-renewing 3-dimensional structures comprised intestinal stem cells and their ...
Wallach, Thomas E, Bayrer, James R
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Bio-Protocol, 2022 In the expanding field of intestinal organoid research, various protocols for three- and two-dimensional organoid-derived cell cultures exist. Two-dimensional organoid-derived monolayers are used to overcome some limitations of three-dimensional organoid
David Warschkau +9 more
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Standard: Human intestinal cancer organoids
Cell Regeneration, 2023 AbstractIntestinal cancer is one of the most frequent and lethal types of cancer. Modeling intestinal cancer using organoids has emerged in the last decade. Human intestinal cancer organoids are physiologically relevant in vitro models, which provides an unprecedented opportunity for fundamental and applied research in colorectal cancer.
Hanqing Lin +25 more
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Human organoids are superior to cell culture models for intestinal barrier research
Frontiers in Cell and Developmental Biology, 2023 Loss of intestinal epithelial barrier function is a hallmark in digestive tract inflammation. The detailed mechanisms remain unclear due to the lack of suitable cell-based models in barrier research.
Catherine Kollmann +10 more
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