Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
core +1 more source
Structuring Human Intestinal Organoids [PDF]
Biophysical Journal, 2016 Organoids are millimeter-scale tissues that replicate the structure and function of naturally formed organs. These tissues are grown in the lab through the directed differentiation of stem cells and have potential uses in biotechnology. Human intestinal organoids (HIO's) serve as a model system for the small intestine and offer potential in ...
Sidar, Barkan +4 more
openaire +1 more source
Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine [PDF]
, 2017 Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin
Aladegbami, Bola +6 more
core +2 more sources
Estrogen enhances female small intestine epithelial organoid regeneration
Journal of Bio-X Research, 2019 . Promoting intestinal epithelial regeneration remains a major medical challenge. Female patients taking nonsteroidal anti-inflammatory drugs are less likely to have upper gastrointestinal bleeding and ulcers than males.
Greg S. Lee +6 more
doaj +1 more source
Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition [PDF]
, 2016 EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light.
Bounova, Gergana +6 more
core +1 more source
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
core +3 more sources
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]
, 2013 Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D +6 more
core +2 more sources
Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation [PDF]
, 2020 International audienceThe nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5 ...
Deutsch, Eric +6 more
core +4 more sources
Intestinal organoids to model cystic fibrosis [PDF]
European Respiratory Journal, 2019 CF can be studied using patient-specific intestinal organoids. CFTR protein function in intestinal organoids correlates with clinical disease severity and drug testing in organoids could aid in finding drugs for people with rare CFTR mutations.https://bit.ly ...
van Mourik, Peter +2 more
openaire +3 more sources
Journal of Tissue Engineering, 2020 Models for enteric neuropathies, in which intestinal nerves are absent or injured, are required to evaluate possible cell therapies. However, existing options, including transgenic mice, are variable and fragile.
David F Chang +9 more
doaj +1 more source