Results 51 to 60 of about 21,783 (297)

Opportunities for organoids as new models of aging. [PDF]

, 2018
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
Antonica, Arora, Astashkina, Auger, Aw, Azpurua, Barbero, Barkauskas, Barkauskas, Barker, Bartfeld, Behjati, Belmin, Ben-Ze’ev, Bhumiratana, Blau, Blokzijl, Brack, Broutier, Busuttil, Caron, Caughey, Cerchiari, Chambers, Chang, Chaudhuri, Choi, Cornacchia, Crabb, Danahay, Dekkers, Dos Santos, Dye, Eiraku, Elahy, Engevik, Freedman, Gao, Garbe, Gjorevski, Greider, Gullapalli, Hannum, Hansen, Hegab, Heintz, Hibiya, Hohwieler, Horvath, Htwe, Huch, Huch, Jennifer L. Hu, Jones, Jung, Karthaus, Kolesky, Koo, Kwong, Lang, Lee, Lee, Levental, Li, Li, Lindahl, Linnemann, Liu, Lozito, Lyons, López-Otín, L’Heureux, Madden, Marciniak, Mark A. LaBarge, Matsui, Mattison, McElwee, Meerwaldt, Mertens, Messner, Michael E. Todhunter, Miller, Moore, Moore, Morizane, Murrow, Myers, Nalapareddy, Nasto, Nelson, Nevalainen, Nguyen-Ngoc, Nicholas, Noguchi, Ootani, O’Brien, Pageon, Pang, Parrinello, Pauli, Phillip, Plaks, Pribluda, Qian, Raja, Rangarajan, Rodriguez-Teja, Ruan, Sancar, Sato, Schütte, Seok, Simian, Singh, Squires, Stampfer, Stearns-Reider, Stojadinovic, Sun, Takasato, Takebe, Tan, Tanos, Toda, Todhunter, Turco, Tzatzalos, van Vliet, Vanhooren, Vernetti, Verzijl, Villadsen, Villeda, Voytik-Harbin, Watson, Williams, Wilson, Workman, Wu, Wylie, Xiang, Yilmaz, Zev J. Gartner, Zhang, Zhang   +145 more
core   +2 more sources

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine [PDF]

, 2016
Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy.
Blyth, Karen, Ceteci, Fatih, Cheung, Eric, Lee, Pearl, Nixon, Colin, Sansom, Owen, Vousden, Karen   +6 more
core   +1 more source

Intestinal Crypt Organoids as Experimental Models [PDF]

, 2015
When it comes to studying the effect of food bioactives on gut health, one of the essential steps that needs to be assessed is characterizing specific effects of the bioactives on the physical barrier of the lumen, the gastrointestinal tissue. In addition to studying the effects on transport function (e.g.
Lukovac, S., Roeselers, G.
openaire   +2 more sources

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]

, 2016
Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson, Arif B. Ekici, Becker, Christoph Becker, Claudia Günther, Cord Brakebusch, Distler, Gionata Fiorino, Heller, Hopkins, Imke Atreya, Kerstin Amann, Lin, Markus F. Neurath, Martin Bergö, Ohkusa, Pastorelli, Pechlivanis, Raja Atreya, Rocío López-Posadas, Silvio Danese, Stefan Tenzer, Stefan Wirtz, Stefania Vetrano, Turcotte, Ulrike Billmeier, Veronika Thonn, Zverina   +27 more
core   +1 more source

Functional characteristics of a pig 2D intestinal organoid model as an in vitro platform for nutritional studies

Journal of Animal Science and Technology
Intestinal epithelial cell lines have been widely used in the field of biomedical and livestock research, and recently, the use of organoid systems has been attempted.
Sang Seok Joo, Bon-Hee Gu, Eunbyeol Lee, Eunseon Oh, Minji Kim, Hyunjung Jung, Myunghoo Kim   +6 more
doaj   +1 more source

Human Organoids for Predictive Toxicology Research and Drug Development

Frontiers in Genetics, 2021
Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or adult tissue stem cells via a process of self-organization that results in the formation of organ-specific cell types.
Toshikatsu Matsui, Tadahiro Shinozawa
doaj   +1 more source

Healing of Human Intestinal Organoids [PDF]

Biophysical Journal, 2016
Organoids are millimeter-scale tissues that replicate the structure and function of naturally formed organs. These tissues are grown in the lab through the directed differentiation of stem cells and have potential uses in biotechnology. Human intestinal organoids (HIO's) serve as a model system for the small intestine and offer potential in ...
Berglund, Emily A., Martinson, Jonathan N.V., Spence, Jason R., Walk, Seth T., Wilking, James N.   +4 more
openaire   +1 more source

Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts.

PLoS ONE, 2018
Although small intestinal epithelial stem cells form crypts when using intestinal culture conditions, colon stem cells usually form colonospheres. Colon mesenchymal cell feeder layers can stimulate colon crypts to form organoids and produce crypts.
Hon Yan Kelvin Yip, Chin Wee Tan, Yumiko Hirokawa, Antony Wilks Burgess   +3 more
doaj   +1 more source

Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling

EBioMedicine, 2020
Background: Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined.
Xiang Hu, Long Zhang, Yaqi Li, Xiaoji Ma, Weixing Dai, Xiaoxue Gao, Xinxin Rao, Guoxiang Fu, Renjie Wang, Mengxue Pan, Qiang Guo, Xiaoya Xu, Yi Zhou, Jianjun Gao, Zhen Zhang, Sanjun Cai, Junjie Peng, Guoqiang Hua   +17 more
doaj   +1 more source

Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection [PDF]

, 2018
Objective Helicobacter pylori causes life-long colonisation of the gastric mucosa, leading to chronic inflammation with increased risk of gastric cancer.
Berger, H., Boccellato, F., Denecke, C., Goosmann, C., Imai-Matsushima, A., Meyer, T., Morey, P., Ordemann, J., Sanchez, G., Schmid, M., Woelffling, S.   +10 more
core   +3 more sources