Results 61 to 70 of about 21,783 (297)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Wuzhishan miniature pig-derived intestinal 2D monolayer organoids to investigate the enteric coronavirus infection

Frontiers in Veterinary Science
Intestinal organoids are valuable tools for investigating intestinal physiology and pathology ex vivo. In previous studies, intestinal organoids of commercial pigs have been developed.
Yuanyuan Liu, Yuanyuan Liu, Yuanyuan Liu, Ning Yang, Ning Yang, Chen Tan, Chen Tan, Chen Tan, Yunhang Zhang, Yunhang Zhang, Yunhang Zhang, Shuai Gao, Yifei Cai, Yifei Cai, Yifei Cai, Yue Zhang, Yuguang Fu, Guangliang Liu, Guangliang Liu, Yang Li, Yang Li   +20 more
doaj   +1 more source

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1. [PDF]

PLoS ONE, 2015
Wnt/beta-catenin signaling plays a central role in guiding the differentiation of the posterior parts of the primitive gut tube into intestinal structures in vivo and some studies suggest that FGF4 is another crucial factor for intestinal development ...
Kaisa Tamminen, Diego Balboa, Sanna Toivonen, Mikko P Pakarinen, Zoltan Wiener, Kari Alitalo, Timo Otonkoski   +6 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids

Stem Cell Research, 2019
The aberrant regulation of the epithelial barrier integrity is involved in many diseases of the digestive tract, including inflammatory bowel diseases and colorectal cancer.
Marco Bardenbacher, Barbara Ruder, Nathalie Britzen-Laurent, Benjamin Schmid, Maximilian Waldner, Elisabeth Naschberger, Michael Scharl, Werner Müller, Claudia Günther, Christoph Becker, Michael Stürzl, Philipp Tripal   +11 more
doaj   +1 more source

Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation [PDF]

, 2017
RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs).
Arora, Vivek K, Bolzenius, Jennifer, Bowman, Gregory R, Chu, Clarence E, Halstead, Angela M, Kapadia, Chiraag D, Schriefer, Andrew, Wartman, Lukas D   +7 more
core   +2 more sources

Intestinal multicellular organoids to study colorectal cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021
Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field.
Idris, Musa, Alves, Maria, Hofstra, Robert M.W., Mahé, Maxime, Melotte, Veerle   +4 more
openaire   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Deliod a lightweight detection model for intestinal organoids based on deep learning

Scientific Reports
Intestinal organoids are indispensable tools for exploring intestinal disorders. Deep learning methodologies are often employed in morphological analysis to evaluate the condition of these organoids.
Yu Sun, Hanwen Zhang, Fengliang Huang, Qin Gao, Peng Li, Dong Li, Gangyin Luo   +6 more
doaj   +1 more source

Organoids as regenerative medicine for inflammatory bowel disease

iScience
Summary: Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global prevalence. Managing disease activity relies on various pharmacological options.
Alexander Hammerhøj, Deepavali Chakravarti, Toshiro Sato, Kim Bak Jensen, Ole Haagen Nielsen   +4 more
doaj   +1 more source