Results 71 to 80 of about 21,783 (297)

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake [PDF]

, 2012
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to ...
Abdulmetin Dursun, Atul K. Bhan, BD Simons, C Beard, CM McCay, D Nakada, DA Guertin, David M. Sabatini, DD Sarbassov, DE Cohen, DT Breault, Dudley W. Lamming, E Sangiorgi, G. Petur Nielsen, GG Altmann, HJ Snippert, J Chen, Khristian E. Bauer-Rowe, Kivanc Birsoy, L Bondolfi, L Zhu, Lawrence R. Zukerberg, LE O’Brien, LG van der Flier, M Podesta, Mari Mino-Kenudson, Martin Selig, N Barker, N Takeda, NY Kalaany, OH Yilmaz, OH Yilmaz, Pekka Katajisto, RP Ertl, S Dunel-Erb, S Hempenstall, S Sengupta, Shomit Sengupta, SR Spindler, T Sato, T Sato, V Marsh, V. Onur Yilmaz, Vikram Deshpande, Yetis Gültekin, Ömer H. Yilmaz   +45 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The application of organoids in colorectal diseases

Frontiers in Pharmacology
Intestinal organoids are a three-dimensional cell culture model derived from colon or pluripotent stem cells. Intestinal organoids constructed in vitro strongly mimic the colon epithelium in cell composition, tissue architecture, and specific functions ...
Yanxin Liu, Dongxu Wang, Yanhong Luan, Boqiang Tao, Qirong Li, Qiang Feng, Hengzong Zhou, Jianfeng Mu, Jinhai Yu   +8 more
doaj   +1 more source

Intestinal organoid co-culture protocol to study cell competition in vitro

STAR Protocols, 2022
Summary: Intestinal organoid cultures are a powerful tool to study epithelial cells in vitro, as they are able to proliferate and differentiate into all cell lineages observed in vivo.
Sanne M. van Neerven, Rana Ramadan, Milou S. van Driel, David J. Huels, Louis Vermeulen   +4 more
doaj   +1 more source

Organoids as a model for colorectal cancer [PDF]

, 2016
Modelling human diseases in in vitro systems is undisputedly an invaluable research tool, yet there are many limitations. Some of those limitations have been overcome through the introduction of organoid culture systems, which have revolutionised ...
Reed, Karen Ruth, Young, Madeleine
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Long-term culture of intestinal cell progenitors: an overview of their development, application, and associated technologies [PDF]

, 2016
Purpose of Review Long-term culture of adult progenitor cells in 3D is a recently emerging technology that inhabits the space between 2D cell lines and organ slice culture.
Hollins, Andrew John, Parry, Lee
core   +1 more source

The zinc finger transcription factor PLAGL2 enhances stem cell fate and activates expression of ASCL2 in intestinal epithelial cells [PDF]

, 2010
O encaminhamento de textos originais para submissão seguem algumas orientações básicas, levando em conta, inicialmente, que devem ser inéditos e que serão submetidos à aprovação de avaliadores especialistas nos temas tratados.
Strubberg, Ashlee M, Veronese Paniagua, Daniel A, Zhao, Tingting, Dublin, Leeran, Pritchard, Thomas, Bayguinov, Peter O, Fitzpatrick, James A.J., Madison, Blair B   +7 more
core   +1 more source

Manipulate intestinal organoids with niobium carbide nanosheets

Journal of Biomedical Materials Research Part A, 2020
AbstractMultifunctional two‐dimensional nanosheet materials have attracted attention in biomedical fields due to their unique physiochemical and biological properties. Interactions between intestinal stem cells and Engineered Nanomaterials (ENMs) are an essential area in research with the growing diagnosis of gastrointestinal (GI) diseases.
Brittney Reding, Prerana Carter, Yijun Qi, Zhe Li, Yue Wu, Michael Wannemuehler, Kaitlin M. Bratlie, Qun Wang   +7 more
openaire   +4 more sources