Results 111 to 120 of about 843,325 (293)

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice

, 2001
Sepsis is associated with increased intestinal permeability, but mediators and mechanisms are not fully understood. We examined the role of interleukin (IL)-6 and IL-10 in sepsis-induced increase in intestinal permeability.
Per-Olof Hasselgren, Cheng Hui Fang, Quan Wang   +2 more
core   +1 more source

Intestinal permeability – a new target for disease prevention and therapy [PDF]

, 2014
Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of debate, and their clinical significance is not ...
Jerry M Wells, Ockhuizen, T., Theo Ockhuizen, Stephan C Bischoff, Bischoff, Stephan C, Buurman, Wim, Serino, Matteo, Bischoff, Stephan C., Schulzke, Jörg-Dieter, Barbara, Giovanni, Matteo Serino, Giovanni Barbara, Alastair Watson, Bischoff, S.C., Schulzke, Jörg Dieter, Watson, Alastair, Herbert Tilg, Wells, J.M., Tilg, Herbert, Schulzke, J.D., Wim Buurman, Watson, A., Wells, Jerry, Jörg-Dieter Schulzke, Buurman, W., Serino, M., Tilg, H., Barbara, G., Wells, Jerry M., Ockhuizen, Theo   +29 more
core   +2 more sources

IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS. [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Because the oral route of drug delivery is incomparable, screening of intestinal permeability and absorption of drug candidates is a critical stage before clinical trials for time and cost reasons.
Ahmed Elgendy, Adeboye Adejare, Saleh Abd El-Rasoul, Abdullah Asiri   +3 more
doaj   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Intestinal permeability and inflammation in patients on NSAIDs

, 1998
Background—The frequency with which non-steroidal anti-inflammatory drugs (NSAIDs) increase small intestinal permeability and cause inflammation is uncertain.Aims—To examine small intestinal permeability and inflammation in a large number of patients on ...
D Scott, I Menzies, R Moots, I Bjarnason, J Hayllar, A Macpherson, G Sigthorsson, M J Gumpel, J Tibble   +8 more
core   +1 more source

Dynamic Electrophoretic Assembly Coupled With Water‐Splitting‐Induced pH Control Enables Precision Ion Sieving Membranes

Advanced Materials, EarlyView.
A green, external‐catalyst‐free route grows defect‐free covalent organic framework membranes directly on ion‐exchange supports using an alternating electric field and in situ‐generated acid. Through a self‐regulating, self‐healing mechanism, the membranes achieve near‐complete, ultra‐fast separation of monovalent ions such as Li+, Na+, and K+, offering
Mohammad Hossein Jandaghian, Petric Marc Ruya, Ipek Ozyurt, Ali Atyabi, Samuel Eyley, Wim Thielemans, Alexander Volodin, Riccardo Alessandri, Xing Yang   +8 more
wiley   +1 more source

MLCK inhibition with ML-9 decreases the burn-induced increase of intestinal permeability.

, 2013
A. Intestinal permeability was assessed by measuring FITC-dextran in the systemic circulation after intraluminal injection of 4.4-kDa FITC-dextran at several time points after 30% TBSA burn injury.
Qin Su (31034), Fengjun Wang (326001), Chuanli Chen (325999), Shiliang Wang (8861), Pei Wang (102036)   +4 more
core   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source